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04-0298108BA0217611819-9771193COLECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50N315NCTC8325NewmanRF122ST398T0131TCH60TW20USA300_FPR3757USA300_TCH1516VC40
NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_0404 [new locus tag: NWMN_RS02285 ]
  • pan locus tag?:
  • symbol: lpl2nm
  • pan gene symbol?:
  • synonym:
  • product: tandem lipoprotein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_0404 [new locus tag: NWMN_RS02285 ]
  • symbol: lpl2nm
  • product: tandem lipoprotein
  • replicon: chromosome
  • strand: +
  • coordinates: 454025..454825
  • length: 801
  • essential: unknown

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGCGATATCTAAAAAAGCTTGCATGGTTCATAAGTGTTATTATTTTGGGCATTTTTATA
    ATAGGTTGTGATAGTTCAAGCGATACTGGGGAAAAAGCAAAAGAAGATTCAAAGGAAGAA
    CAAATCAAAAAGAGCTTTGCGAAAACATTAGATATGTATCCAATTAAGAATCTCGAGGAC
    TTATATGACGAAGAAGGATATCGAGATAGCGAATTTAAAAAAGGTGACAAAGGGATGTGG
    ACGATATATACAGATTTCGCCAAAAGTAATAAACCGGGTGTATTAGATAATGAAGGTATG
    ATTTTAAATTTGGATAGAAATACACGTACGGCCAAGGGATATTATTTTGTAGATACTATA
    TATGACAATCATGAAAACTCTTATAGTAAAAATTATAGAGTTGAGATGAAAAACAATAAA
    ATTATTTTATTAGACAAGGTGGAAGATCAAAAACTTAAAGAAAGAATAGAAAACTTTAAA
    TTTTTCGGACAATATGCCGATTTCAAGAGTTTGAAAAGTTACAACAATGGCGACGTTTCA
    ATTAATAGTAATGTTCCAAGTTATGACGCGAAATTTAAAATGAGTAATAAAGATGAAAAT
    GTTAAGCAATTAAGAAGTCGTTATAACATTCCTACTGAAAAAGCTCCAATATTAAAAATG
    CATATTGATGGGGACTTAAAAGGCAGTTCCGTTGGATATAAAAAGTTAGAAATAGACTTT
    TCAAAAGAAGAAAATAGCGAATTATCAGTAGTCGATTCATTAAATTTTCAGCCTGCCAAA
    AAAAATAAAGATGATGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    801

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_0404 [new locus tag: NWMN_RS02285 ]
  • symbol: Lpl2nm
  • description: tandem lipoprotein
  • length: 266
  • theoretical pI: 6.58167
  • theoretical MW: 30887.6
  • GRAVY: -0.853007

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Staphylococcus tandem lipoproteins (TIGR01742; HMM-score: 385.5)
  • TheSEED:  
    Tandem lipoprotein within Pathogenicity island 
  • PFAM:
    LolA_LolB (CL0048) DUF576; Csa1 family (PF04507; HMM-score: 366.4)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 3.33
    • Cellwall Score: 3.33
    • Extracellular Score: 3.33
    • Internal Helix: 1
  • LocateP: Lipid anchored
    • Prediction by SwissProt Classification: Extracellular
    • Pathway Prediction: Sec-(SPII)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: 0
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: IFIIGCD
  • SignalP: Signal peptide length 28 aa
    • Ymax: 0.511
    • Ymax_pos: 28
    • Cmax: 0.408
    • Cmax_pos: 28
    • Smax: 0.756
    • Smax_pos: 23
    • Smean: 0.529
    • D: 0.518
  • predicted transmembrane helices (TMHMM): 1

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MRYLKKLAWFISVIILGIFIIGCDSSSDTGEKAKEDSKEEQIKKSFAKTLDMYPIKNLEDLYDEEGYRDSEFKKGDKGMWTIYTDFAKSNKPGVLDNEGMILNLDRNTRTAKGYYFVDTIYDNHENSYSKNYRVEMKNNKIILLDKVEDQKLKERIENFKFFGQYADFKSLKSYNNGDVSINSNVPSYDAKFKMSNKDENVKQLRSRYNIPTEKAPILKMHIDGDLKGSSVGYKKLEIDFSKEENSELSVVDSLNFQPAKKNKDDE

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator: SaeR
    SaeR (TF) important in Virulence

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]