From AureoWiki
Jump to: navigation, search
NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_0684 [new locus tag: NWMN_RS03865 ]
  • pan locus tag?: SAUPAN002601000
  • symbol: pabC
  • pan gene symbol?:
  • synonym:
  • product: 4-amino-4-deoxychorismate lyase

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_0684 [new locus tag: NWMN_RS03865 ]
  • symbol: pabC
  • product: 4-amino-4-deoxychorismate lyase
  • replicon: chromosome
  • strand: +
  • coordinates: 764439..765047
  • length: 609
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGCAATTATTTGAAACAATGAAAATTGATAATGGACATATCCCTAGACTTACTTATCAT
    ACTAATCGCATAAAATGTTCTTCTGAGCGATTAAACTTTAAATTTGATGAACATGCATGG
    CGAAATGAATTAAACGATGTAACAACAAAGTATCACAGTGGTCAATATAGACTTAAAATC
    GTATTAAATGCTGAAAGCAAATTTGAAACGATAGTGTCACCTTTACCTGAGAAAAGTAGT
    TTTACAGCAAAATTTCAAGTGTTGCCCAAAGTAGTTAATCCAACTTTTATAAAAAATAAA
    ACGACAGAACGAAAGCATTTAGCACACAATCATGAAACAGATTTAATATTGCTAACTTCA
    GAGGACGGCAAGGTCCTTGAATTTGATATTGGCAACATTGTCATTGAAGAGGATGGAAAA
    TGGTACACACCAAGTTATAAAGATGATTTCTTAAAAGGATGCATGCGTGATTATTTAATA
    GATAGTGACAAACTTGTTGAAAAAGACTTTAATAAAAACGAATTGATTTATAAATATCAT
    AACAATGAGATACGTTTATTTTTGATAAATAGTTTACGAGAGGTTGCCGATGTCCACCTT
    TGCCTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    609

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_0684 [new locus tag: NWMN_RS03865 ]
  • symbol: PabC
  • description: 4-amino-4-deoxychorismate lyase
  • length: 202
  • theoretical pI: 7.01683
  • theoretical MW: 23840
  • GRAVY: -0.569802

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersFolic acidaminodeoxychorismate lyase (TIGR03461; EC 4.1.3.38; HMM-score: 49.7)
    MetabolismAmino acid biosynthesisPyruvate familybranched-chain amino acid aminotransferase (TIGR01122; EC 2.6.1.42; HMM-score: 14.3)
  • TheSEED:  
    Amino Acids and DerivativesAromatic amino acids and derivativesTryptophan synthesis Aminodeoxychorismate lyase (EC 4.1.3.38) 
    Cofactors, Vitamins, Prosthetic Groups, PigmentsFolate and pterinesFolate Biosynthesis Aminodeoxychorismate lyase (EC 4.1.3.38) 
    COG1399 Aminodeoxychorismate lyase (EC 4.1.3.38) 
  • PFAM:
    no clan definedAminotran_4; Amino-transferase class IV (PF01063; HMM-score: 129.9)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular Possibility: 1
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.129
    • Ymax_pos: 40
    • Cmax: 0.123
    • Cmax_pos: 40
    • Smax: 0.184
    • Smax_pos: 8
    • Smean: 0.124
    • D: 0.127
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MQLFETMKIDNGHIPRLTYHTNRIKCSSERLNFKFDEHAWRNELNDVTTKYHSGQYRLKIVLNAESKFETIVSPLPEKSSFTAKFQVLPKVVNPTFIKNKTTERKHLAHNHETDLILLTSEDGKVLEFDIGNIVIEEDGKWYTPSYKDDFLKGCMRDYLIDSDKLVEKDFNKNELIYKYHNNEIRLFLINSLREVADVHLCL

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]