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NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_1185 [new locus tag: NWMN_RS06680 ]
  • pan locus tag?: SAUPAN003577000
  • symbol: ftsK
  • pan gene symbol?: ftsK
  • synonym:
  • product: DNA translocase FtsK/SpoIIIE family protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_1185 [new locus tag: NWMN_RS06680 ]
  • symbol: ftsK
  • product: DNA translocase FtsK/SpoIIIE family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1306308..1308677
  • length: 2370
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    TTGGCACAAGCAAAAAAGAAATCGACAGCTAAGAAAAAAACAACATCAAAAAAAAGAACA
    AATTCGAGGAAAAAGAAGAATGATAATCCGATACGTTATGTCATAGCTATTTTAGTAGTT
    GTATTAATGGTGTTGGGTGTTTTCCAATTAGGAATAATAGGTCGTCTAATTGACAGCTTC
    TTTAATTATTTATTTGGGTACAGTAGATATTTAACATATATTTTAGTACTCTTAGCAACT
    GGTTTTATTACATACTCTAAACGTATTCCTAAAACTAGACGAACGGCTGGTTCGATTGTA
    TTGCAAATTGCATTGCTATTTGTATCACAGTTAGTTTTTCATTTTAATAGTGGTATCAAA
    GCTGAAAGAGAACCTGTACTTTCTTATGTGTATCAGTCATACCAACATAGTCATTTCCCA
    AATTTTGGTGGCGGTGTATTAGGCTTTTATTTATTAGAGTTAAGCGTACCTTTAATTTCA
    TTATTTGGTGTATGTATTATTACTATTTTATTATTATGCTCAAGTGTTATTTTATTAACA
    AACCATCAACATCGTGAAGTTGCAAAAGTTGCACTGGAAAATATAAAAGCTTGGTTTGGT
    TCATTTAATGAAAAAATGTCGGAAAGAAACCAAGAAAAACAATTGAAGCGTGAAGAAAAA
    GCAAGACTTAAAGAAGAACAAAAGGCACGTCAAAATGAACAGCCACAAATAAAAGATGTG
    AGTGATTTTACGGAAGTGCCTCAAGAAAGAGATATTCCAATTTATGGGCATACTGAAAAT
    GAAAGTAAAAGCCAGAGTCAACCAAGTCGAAAAAAACGAGTGTTTGATGCAGAGAATAGT
    TCGAATAACATCGTAAATCATCATCAAGCAGATCAGCAAGAACAATTAACAGAACAAACT
    CATAACAGTGTTGAAAGTGAAAACACTATTGAAGAAGCTGGTGAAGTTACGAATGTATCG
    TATGTTGTTCCACCGTTAACTTTACTTAATCAACCTGCAAAACAAAAAGCAACATCTAAA
    GCTGAAGTGCAACGTAAAGGACAAGTACTAGAGAATACATTAAAAGATTTTGGGGTAAAT
    GCAAAAGTGACACAAATTAAAATTGGTCCTGCAGTAACTCAATATGAAATTCAACCAGCT
    CAAGGGGTTAAAGTGAGTAAAATTGTAAACTTGCATAATGATATTGCATTAGCTTTAGCA
    GCAAAAGATGTTAGAATCGAAGCGCCAATACCTGGTCGTTCTGCAGTAGGTATTGAAGTG
    CCAAATGAGAAAATTTCATTAGTTTCACTAAAAGAAGTTTTAGATGAAAAATTCCCGTCT
    AATAATAAACTAGAAGTTGGATTAGGAAGAGATATATCAGGTGATCCAATTACTGTTCCA
    CTAAATGAAATGCCACACTTATTGGTGGCAGGATCGACGGGTAGTGGTAAATCTGTTTGT
    ATAAATGGTATTATTACAAGTATTTTATTAAATGCTAAGCCGCATGAAGTTAAACTTATG
    TTAATCGATCCGAAAATGGTTGAACTAAATGTTTATAACGGAATTCCACACTTATTAATT
    CCGGTTGTTACAAATCCTCATAAAGCTGCTCAAGCTTTAGAAAAAATTGTAGCTGAGATG
    GAAAGACGTTATGATTTATTCCAACATTCATCAACTAGAAACATTAAAGGTTATAACGAA
    TTAATCCGTAAGCAAAATCAAGAATTAGATGAGAAGCAACCAGAATTACCTTATATCGTT
    GTTATTGTAGATGAGCTTGCAGATTTAATGATGGTAGCTGGTAAAGAAGTTGAAAATGCG
    ATTCAACGTATTACACAAATGGCACGTGCAGCAGGTATACATTTAATTGTAGCGACACAA
    AGACCTTCTGTGGATGTAATTACAGGTATCATTAAAAATAATATTCCATCTAGAATAGCT
    TTTGCTGTGAGTTCTCAAACAGATTCAAGAACTATTATTGGTACTGGCGGCGCAGAAAAG
    TTACTTGGTAAAGGTGACATGTTATACGTTGGAAATGGTGACTCATCACAAACACGTATT
    CAAGGGGCGTTTTTAAGTGACCAAGAGGTGCAAGATGTTGTAAATTATGTAGTAGAACAA
    CAACAGGCAAATTATGTAAAAGAAATGGAACCAGATGCACCAGTGGATAAATCGGAAATG
    AAAAGTGAAGATGCTTTATATGATGAAGCGTATTTGTTTGTTGTTGAACAACAAAAGGCA
    AGTACATCATTGTTACAACGCCAATTTAGAATTGGTTATAATAGAGCATCTAGGTTGATG
    GATGATTTAGAACGCAATCAGGTAATCGGTCCACAAAAAGGAAGCAAGCCTAGACAAGTT
    TTAATAGATCTTAATAATGACGAGGTGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2370

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_1185 [new locus tag: NWMN_RS06680 ]
  • symbol: FtsK
  • description: DNA translocase FtsK/SpoIIIE family protein
  • length: 789
  • theoretical pI: 9.05508
  • theoretical MW: 88172.5
  • GRAVY: -0.294677

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype VII secretion protein EssC (TIGR03928; HMM-score: 123.9)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype VII secretion protein EccCa (TIGR03924; HMM-score: 103)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype VII secretion protein EccCb (TIGR03925; HMM-score: 64.9)
    Genetic information processingMobile and extrachromosomal element functionsOtherconjugative coupling factor TraD, SXT/TOL subfamily (TIGR03743; HMM-score: 14.7)
    type IV conjugative transfer system coupling protein TraD (TIGR02759; HMM-score: 12.3)
    MetabolismTransport and binding proteinsCations and iron carrying compoundscation transporter family protein (TIGR00860; HMM-score: 11.3)
  • TheSEED:  
    Cell Division and Cell CycleCell Division and Cell Cycle - no subcategoryBacterial Cytoskeleton Cell division protein FtsK 
    Bacterial Cell Division Cell division protein FtsK 
    Bacterial RNA-metabolizing Zn-dependent hydrolases Cell division protein FtsK 
  • PFAM:
    P-loop_NTPase (CL0023) FtsK_SpoIIIE; FtsK/SpoIIIE family (PF01580; HMM-score: 205.4)
    HTH (CL0123) Ftsk_gamma; Ftsk gamma domain (PF09397; HMM-score: 100.6)
    P-loop_NTPase (CL0023) AAA_10; AAA-like domain (PF12846; HMM-score: 26.4)
    no clan definedFtsK_4TM; 4TM region of DNA translocase FtsK/SpoIIIE (PF13491; HMM-score: 21.2)
    P-loop_NTPase (CL0023) AAA_19; AAA domain (PF13245; HMM-score: 20.7)
    DUF87; Domain of unknown function DUF87 (PF01935; HMM-score: 20.3)
    AAA_22; AAA domain (PF13401; HMM-score: 16.9)
    T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 15.4)
    no clan definedNeur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region (PF02932; HMM-score: 15)
    P-loop_NTPase (CL0023) TrwB_AAD_bind; Type IV secretion-system coupling protein DNA-binding domain (PF10412; HMM-score: 14.8)
    Marvel-like (CL0396) MARVEL; Membrane-associating domain (PF01284; HMM-score: 14.7)
    no clan definedCrgA; Cell division protein CrgA (PF06781; HMM-score: 14.1)
    P-loop_NTPase (CL0023) AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 14)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 13.4)
    ClpP_crotonase (CL0127) Peptidase_S49_N; Peptidase family S49 N-terminal (PF08496; HMM-score: 11.6)
    no clan definedCodanin-1_C; Codanin-1 C-terminus (PF15296; HMM-score: 10.9)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: -0.5
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.253
    • Ymax_pos: 11
    • Cmax: 0.129
    • Cmax_pos: 5
    • Smax: 0.74
    • Smax_pos: 6
    • Smean: 0.628
    • D: 0.399
  • predicted transmembrane helices (TMHMM): 5

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MAQAKKKSTAKKKTTSKKRTNSRKKKNDNPIRYVIAILVVVLMVLGVFQLGIIGRLIDSFFNYLFGYSRYLTYILVLLATGFITYSKRIPKTRRTAGSIVLQIALLFVSQLVFHFNSGIKAEREPVLSYVYQSYQHSHFPNFGGGVLGFYLLELSVPLISLFGVCIITILLLCSSVILLTNHQHREVAKVALENIKAWFGSFNEKMSERNQEKQLKREEKARLKEEQKARQNEQPQIKDVSDFTEVPQERDIPIYGHTENESKSQSQPSRKKRVFDAENSSNNIVNHHQADQQEQLTEQTHNSVESENTIEEAGEVTNVSYVVPPLTLLNQPAKQKATSKAEVQRKGQVLENTLKDFGVNAKVTQIKIGPAVTQYEIQPAQGVKVSKIVNLHNDIALALAAKDVRIEAPIPGRSAVGIEVPNEKISLVSLKEVLDEKFPSNNKLEVGLGRDISGDPITVPLNEMPHLLVAGSTGSGKSVCINGIITSILLNAKPHEVKLMLIDPKMVELNVYNGIPHLLIPVVTNPHKAAQALEKIVAEMERRYDLFQHSSTRNIKGYNELIRKQNQELDEKQPELPYIVVIVDELADLMMVAGKEVENAIQRITQMARAAGIHLIVATQRPSVDVITGIIKNNIPSRIAFAVSSQTDSRTIIGTGGAEKLLGKGDMLYVGNGDSSQTRIQGAFLSDQEVQDVVNYVVEQQQANYVKEMEPDAPVDKSEMKSEDALYDEAYLFVVEQQKASTSLLQRQFRIGYNRASRLMDDLERNQVIGPQKGSKPRQVLIDLNNDEV

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]