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NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_1955 [new locus tag: NWMN_RS11280 ]
  • pan locus tag?: SAUPAN005296000
  • symbol: NWMN_1955
  • pan gene symbol?:
  • synonym:
  • product: MutS domain-containing protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_1955 [new locus tag: NWMN_RS11280 ]
  • symbol: NWMN_1955
  • product: MutS domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 2164670..2166280
  • length: 1611
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    ATGAGCACAAATCAAACATTTTTAATATTTGTTATAGCAATTATTCTACTTACATCTGTA
    ATAGGAATTGTTGGACGATACATGAGTCGTCAACGTCTATTAAAATCTATGGAAACATTA
    TGGCAAACGATTTCTCCATTAGAAGCTTTTATCAGACCGAACTCACATTTCGACTATGAG
    TATAAGCTCTACAAGGAAAAATTTGAATCACATTCATTAGTTGATGATAAAACTTGGTCC
    GACTTAAATATGAATGCAATCTTTCATAAGATGAATTATAATTTAACAGCTATTGGTGAA
    ATGAAGCTATATGCCTGTTTACGTGGAATGCTTTCAATTACGAACAAATCATTACTTAGT
    TTATTTAATGATAATGCTGAATTTAGAAAAAACGTAACATATCATTTAGCTTTGATTGGT
    AAAACTGTTTATCCAACATTTCCAGACCAAATCACACCGGTAAAACGTCAAAATATATTG
    TTTCTATGCCCGTTTTTACCAGTTATCTCATTTGCAGTTATATTTATTAATTCACAAGTT
    GGTATTTTATTATTTCTTATGAGTTGCCTATTTAATATCATTTTATCAGCAACTTTAAAG
    CGTACATATGAGGATGACTTAAAATCTATCTTTTATGCATCCAATGTTTTAAAACAAGGC
    TATACTATCTCAAAAATTAAACATGCTCCACAACCTGAAGTCAATTTTAAGCAATTTAGA
    ACAGCACGTCATTTAACGAGTGTTTTAGCTGAAGTTAATGATGAAGATATCGGAGCTATG
    GTAATTAAACTAGTTAAACTTATTTTCATGCTTGATTATGTTTTATTTCATTCAATTCAA
    AAAAGCTATACAACACATATGAATGAGCTTAAAAATTGTTTCGATTACATAGCTGAATTA
    GATAATCATTATGCATTAGCAATGTATCGTAGAACGCTAGAATGTTATACTGAACCACAA
    ATTGATGATTCAAATGATGGCATAGTATTCTCTGAGTTAACACATCCACTCATAGCAGAT
    GCAGTAGCCAATGATTTCTCACTATCACAAAATATACTGTTAACTGGGTCTAATGCTTCG
    GGTAAATCAACATTTATGAAATCCATAGCAATAAACATTATTCTTGCATCGGCTATACAA
    ACAGTTACCGCAAGCAAATTTGTATATCAACCTGGAATTGTGTTCACGTCAATGGCAAAT
    GCCGATGATGTGTTATCAGGCGATAGTTATTTTATGGCTGAATTAAAATCTATTAAGCGT
    ATTGTTGAAATTCCAGATAATCAAAAAATATACTGCTTTATAGATGAAATTTTTAAAGGT
    ACCAACACAACTGAACGAATTGCCGCTTCAGAATCAGTACTATCATTTTTACATGAAAAA
    TCTAACTTTAGAGTTATTGCAGCAACACATGATATTGAGTTAGCTGAACTCTTAAAACAA
    CGTTATGAAAATTACCATTTCAATGAGGTAATAGAAAATAATAACATACATTTTGATTAC
    AAAATTAAGCCTGGCAAAGCAAATACACGTAATGCCATCGAATTATTAAAAATCACTTCA
    TTTCCAGCAAAAATATATGAACGAGCAAAAGATAATGTCCCGAAAATTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1611

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_1955 [new locus tag: NWMN_RS11280 ]
  • symbol: NWMN_1955
  • description: MutS domain-containing protein
  • length: 536
  • theoretical pI: 7.6459
  • theoretical MW: 61321.6
  • GRAVY: 0.0182836

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Genetic information processingDNA metabolismDNA replication, recombination, and repairDNA mismatch repair protein MutS (TIGR01070; HMM-score: 120.7)
    Genetic information processingDNA metabolismOtherMutS2 family protein (TIGR01069; HMM-score: 59.9)
    P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 13.3)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype VII secretion protein EccCb (TIGR03925; HMM-score: 12.7)
    MetabolismTransport and binding proteinsCations and iron carrying compoundscobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 11.8)
  • TheSEED:  
    DNA MetabolismDNA repairDNA repair, bacterial MutL-MutS system MutS-related protein, family 1 
  • PFAM:
    P-loop_NTPase (CL0023) MutS_V; MutS domain V (PF00488; HMM-score: 104.3)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 20.4)
    AAA_14; AAA domain (PF13173; HMM-score: 20)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 19.4)
    G-alpha; G-protein alpha subunit (PF00503; HMM-score: 16.8)
    FtsK_SpoIIIE; FtsK/SpoIIIE family (PF01580; HMM-score: 15.4)
    ABC_tran; ABC transporter (PF00005; HMM-score: 14.7)
    T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 13.1)
    AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 12.2)
    no clan definedBaculo_11_kDa; Baculovirus 11 kDa family (PF06143; HMM-score: 7.1)
    Sigma_reg_N; Sigma factor regulator N-terminal (PF13800; HMM-score: 6.6)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.07
    • Cytoplasmic Membrane Score: 9.55
    • Cellwall Score: 0.18
    • Extracellular Score: 0.21
    • Internal Helices: 3
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: -0.5
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.162
    • Ymax_pos: 11
    • Cmax: 0.159
    • Cmax_pos: 27
    • Smax: 0.337
    • Smax_pos: 6
    • Smean: 0.276
    • D: 0.206
  • predicted transmembrane helices (TMHMM): 2

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MSTNQTFLIFVIAIILLTSVIGIVGRYMSRQRLLKSMETLWQTISPLEAFIRPNSHFDYEYKLYKEKFESHSLVDDKTWSDLNMNAIFHKMNYNLTAIGEMKLYACLRGMLSITNKSLLSLFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNILFLCPFLPVISFAVIFINSQVGILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFRTARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAELDNHYALAMYRRTLECYTEPQIDDSNDGIVFSELTHPLIADAVANDFSLSQNILLTGSNASGKSTFMKSIAINIILASAIQTVTASKFVYQPGIVFTSMANADDVLSGDSYFMAELKSIKRIVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQRYENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVPKI

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]