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NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_2047 [new locus tag: NWMN_RS11820 ]
  • pan locus tag?: SAUPAN005440000
  • symbol: manA1
  • pan gene symbol?: manA
  • synonym:
  • product: mannose-6-phosphate isomerase, class I

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_2047 [new locus tag: NWMN_RS11820 ]
  • symbol: manA1
  • product: mannose-6-phosphate isomerase, class I
  • replicon: chromosome
  • strand: -
  • coordinates: 2264475..2265413
  • length: 939
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGCCATTATTTTTACAACCAATTTTAAAAACAAAATTATGGGGCGGTCAACGTCTAAGT
    GAGTTTGGATATCAATTAGACAATGATACAACTGGGGAATGTTGGTGTGTGTCAGCACAT
    CCAAATGGTACGAGCGAGATTATTAATGGACCATATCAAGGTCAAACATTAGACCGTATT
    TGGTCAGAACATCGTGAATTGTTTGGTGATTTCCCAAGCAAAGATTTTCCGCTTCTAACT
    AAAATAGTGGATGCAAGAGAATCACTTTCTATTCATGTGCACCCTGATAATTCTTATGCT
    TATGAGCATGAAAACGGGCAATATGGCAAATCTGAATGTTGGTATATTATAGATGCAGAA
    GAAGATGCAGAAATAGTTATAGGGACATTAGCAGAGTCTAGAGAAGAAGTTGCGAATCAT
    GTTCAACACGGAACGATAGAGTCGATACTTAGATATATTAAAGTAAAACCTGGAGAATTC
    TATTTTATTCCAGCAGGAACAGTACATACTATTTCTTCAGGAATATTAGCATACGAAACG
    ATGCAATCGTCAGACATTACATATAGACTTTATGATTTCAATCGTCAAGATAATCAATAT
    AATGATAGACCGTTAAATATTGAAAAAGCTTTAGACGTTATTCAGTACAATGCACCATTA
    CCTAATATTTTGCCTGAAAGCGAAATTATTGAAAACCATAAGTGTACACACATTGTATCG
    AATGATTTCTTTACATTGGTTAAATGGGAAATTTCTGGCACGTTAAATTATATGAAGCCT
    AGAGAGTTCTGTTTAGTTACAGTGTTGGAAGGCGAAGGGCAAATGATTGTCGATGGTGAA
    ATTTTCAAACTGACTACTGGTACAAACTTTATTTTGACTTCTGAAGATTTGGATAGTGTC
    TTTGAAGGTGATTTCACATTGATGATTAGCTATGTGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    939

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_2047 [new locus tag: NWMN_RS11820 ]
  • symbol: ManA1
  • description: mannose-6-phosphate isomerase, class I
  • length: 312
  • theoretical pI: 4.32935
  • theoretical MW: 35642.7
  • GRAVY: -0.309295

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    MetabolismEnergy metabolismSugarsmannose-6-phosphate isomerase, class I (TIGR00218; EC 5.3.1.8; HMM-score: 192.7)
  • TheSEED:  
    CarbohydratesMonosaccharidesMannose Metabolism Mannose-6-phosphate isomerase, class I (EC 5.3.1.8) 
  • PFAM:
    Cupin (CL0029) PMI_typeI; Phosphomannose isomerase type I (PF01238; HMM-score: 97.2)
    Cupin_2; Cupin domain (PF07883; HMM-score: 29.2)
    JmjC; JmjC domain, hydroxylase (PF02373; HMM-score: 17.4)
    AraC_binding; AraC-like ligand binding domain (PF02311; HMM-score: 17.3)
    Cupin_3; Protein of unknown function (DUF861) (PF05899; HMM-score: 11.9)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular Possibility: 1
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.15
    • Ymax_pos: 11
    • Cmax: 0.127
    • Cmax_pos: 55
    • Smax: 0.277
    • Smax_pos: 4
    • Smean: 0.217
    • D: 0.176
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]