NCBI: 06-JUL-2013
Contents
⊟Summary[edit source | edit]
- organism: Staphylococcus aureus Newman
- locus tag: NWMN_2504 [new locus tag: NWMN_RS14370 ]
- pan locus tag?: SAUPAN006306000
- symbol: NWMN_2504
- pan gene symbol?: lqo
- synonym:
- product: malate:quinone oxidoreductase
⊟Genome View[edit source | edit]
⊟Gene[edit source | edit]
⊟General[edit source | edit]
- type: CDS
- locus tag: NWMN_2504 [new locus tag: NWMN_RS14370 ]
- symbol: NWMN_2504
- product: malate:quinone oxidoreductase
- replicon: chromosome
- strand: -
- coordinates: 2750223..2751719
- length: 1497
- essential: unknown other strains
⊟Accession numbers[edit source | edit]
- Gene ID: 5331555 NCBI
- RefSeq: YP_001333538 NCBI
- BioCyc:
- MicrobesOnline: 3708106 MicrobesOnline
⊟Phenotype[edit source | edit]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit source | edit]
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1441ATGGCTAAGTCTAATAGTAAAGACATCGTTTTAATTGGAGCCGGTGTACTTAGCACAACA
TTTGGTTCAATGTTAAAAGAAATTGAGCCAGACTGGAATATCCACGTTTACGAACGCTTG
GATCGTCCTGCAATCGAAAGTTCAAACGAAAGAAATAATGCTGGTACGGGTCATGCAGCA
TTATGTGAGTTGAACTACACAGTTTTACAACCTGATGGTTCTATCGACATCGAAAAAGCG
AAAGTGATTAACGAAGAGTTTGAGATTTCAAAACAATTCTGGGGTCACTTAGTGAAAAGC
GGTAGCATCGAGAACCCAAGAGAATTTATCAATCCATTACCACACATCAGTTATGTTAGA
GGTAAAAACAATGTTAAATTCTTAAAAGATCGTTACGAAGCGATGAAAGCTTTCCCTATG
TTCGATAATATCGAATATACTGAAGACATCGAAGTAATGAAAAAATGGATTCCATTGATG
ATGAAAGGCCGTGAAGATAACCCTGGTATCATGGCGGCAAGTAAAATTGACGAAGGTACA
GATGTAAACTTCGGTGAATTAACACGTAAAATGGCTAAAAGCATTGAAGCACATCCAAAT
GCTACAGTGCAATTTAACCATGAAGTTGTTGATTTTGAACAATTATCAAATGGTCAATGG
GAAGTTACTGTTAAAAATCGCCTAACTGGTGAGAAATTCAAACAAGTAACTGACTACGTA
TTCATCGGTGCTGGCGGTGGAGCAATTCCATTATTACAAAAAACAGGTATCCCTGAAAGT
AAACATTTGGGTGGATTCCCTATCAGTGGTCAATTCTTAGCTTGTACAAACCCACAAGTT
ATTGAACAACACGATGCCAAAGTTTATGGTAAAGAGCCACCTGGTACACCACCAATGACT
GTACCTCATTTAGATACGCGTTACATTGATGGTCAAAGAACATTATTATTTGGACCATTT
GCTAATGTTGGACCTAAATTCTTGAAAAATGGTTCTAACTTAGATTTATTCAAGTCTGTT
AAAACATACAACATTACAACTTTATTAGCAGCAGCAGTTAAAAACTTACCTTTAATTAAA
TACTCATTTGACCAAGTAATTATGACAAAAGAAGGTTGTATGAACCACTTACGTACTTTC
TATCCAGAAGCACGTAATGAAGATTGGCAATTATACACTGCTGGTAAACGTGTACAAGTT
ATCAAAGATACACCTGAACACGGTAAAGGATTCATCCAATTCGGTACAGAAGTGGTTAAC
TCACAAGACCACACTGTAATTGCATTATTAGGTGAATCACCAGGGGCTTCAACTTCAGTT
TCAGTTGCGTTAGAAGTATTAGAACGTAACTTCCCTGAATACAAAACTGAATGGGCACCT
AAAATTAAGAAAATGATTCCATCATACGGTGAATCATTAATTGAAGACGAAAAATTAATG
AGAAAAATCCGTAAACAAACTTCAAAAGACTTAGAATTAGGTTACTACGAAAACTAA60
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⊟Protein[edit source | edit]
⊟General[edit source | edit]
- locus tag: NWMN_2504 [new locus tag: NWMN_RS14370 ]
- symbol: NWMN_2504
- description: malate:quinone oxidoreductase
- length: 498
- theoretical pI: 6.52415
- theoretical MW: 55998.5
- GRAVY: -0.430924
⊟Function[edit source | edit]
- reaction: EC 1.1.5.4? ExPASyMalate dehydrogenase (quinone)(S)-malate + a quinone = oxaloacetate + reduced quinone
- TIGRFAM: Energy metabolismTCA cyclemalate dehydrogenase (acceptor) (TIGR01320; EC 1.1.5.4; HMM-score: 633.5)and 2 moreCellular processesDetoxificationCoA-disulfide reductase (TIGR03385; EC 1.8.1.14; HMM-score: 16.2)conserved hypothetical protein (TIGR04540; HMM-score: 12.8)
- TheSEED: CarbohydratesCentral carbohydrate metabolismacinetobacter tca Malate:quinone oxidoreductase (EC 1.1.5.4)and 1 more
- PFAM: NADP_Rossmann (CL0063) Mqo; Malate:quinone oxidoreductase (Mqo) (PF06039; HMM-score: 719.5)and 2 moreDAO; FAD dependent oxidoreductase (PF01266; HMM-score: 22.9)K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring) (PF13434; HMM-score: 13)
⊟Structure, modifications & interactions[edit source | edit]
- domains:
- modifications:
- cofactors: FAD
- effectors:
- protein partners:
NWMN_1483 (dnaK) molecular chaperone DnaK [1] (data from MRSA252) NWMN_0509 (fus) elongation factor G [1] (data from MRSA252) NWMN_2446 (mvaS) 3-hydroxy-3-methylglutaryl coenzyme A synthase [1] (data from MRSA252) NWMN_1592 (pykA) pyruvate kinase [1] (data from MRSA252) NWMN_0500 (rplA) 50S ribosomal protein L1 [1] (data from MRSA252) NWMN_2140 (rplE) 50S ribosomal protein L5 [1] (data from MRSA252) NWMN_0501 (rplJ) 50S ribosomal protein L10 [1] (data from MRSA252) NWMN_0499 (rplK) 50S ribosomal protein L11 [1] (data from MRSA252) NWMN_2150 (rplW) 50S ribosomal protein L23 [1] (data from MRSA252) NWMN_2135 (rpsE) 30S ribosomal protein S5 [1] (data from MRSA252) NWMN_0508 (rpsG) 30S ribosomal protein S7 [1] (data from MRSA252)
⊟Localization[edit source | edit]
- PSORTb: Cellwall
- Cytoplasmic Score: 0.01
- Cytoplasmic Membrane Score: 0.53
- Cellwall Score: 8.75
- Extracellular Score: 0.7
- Internal Helices: 0
- LocateP: Intracellular
- Prediction by SwissProt Classification: Cytoplasmic
- Pathway Prediction: No pathway
- Intracellular Possibility: 0.83
- Signal Peptide Possibility: -0.5
- N-terminally Anchored Score: 1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- Ymax: 0.195
- Ymax_pos: 26
- Cmax: 0.139
- Cmax_pos: 60
- Smax: 0.372
- Smax_pos: 25
- Smean: 0.304
- D: 0.237
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit source | edit]
⊟Protein sequence[edit source | edit]
- MAKSNSKDIVLIGAGVLSTTFGSMLKEIEPDWNIHVYERLDRPAIESSNERNNAGTGHAALCELNYTVLQPDGSIDIEKAKVINEEFEISKQFWGHLVKSGSIENPREFINPLPHISYVRGKNNVKFLKDRYEAMKAFPMFDNIEYTEDIEVMKKWIPLMMKGREDNPGIMAASKIDEGTDVNFGELTRKMAKSIEAHPNATVQFNHEVVDFEQLSNGQWEVTVKNRLTGEKFKQVTDYVFIGAGGGAIPLLQKTGIPESKHLGGFPISGQFLACTNPQVIEQHDAKVYGKEPPGTPPMTVPHLDTRYIDGQRTLLFGPFANVGPKFLKNGSNLDLFKSVKTYNITTLLAAAVKNLPLIKYSFDQVIMTKEGCMNHLRTFYPEARNEDWQLYTAGKRVQVIKDTPEHGKGFIQFGTEVVNSQDHTVIALLGESPGASTSVSVALEVLERNFPEYKTEWAPKIKKMIPSYGESLIEDEKLMRKIRKQTSKDLELGYYEN
⊟Experimental data[edit source | edit]
- experimentally validated: no data available
⊟Expression & Regulation[edit source | edit]
⊟Operon[edit source | edit]
- NWMN_2504 no polycistronic organisation predicted
⊟Regulation[edit source | edit]
- regulator:
⊟Transcription pattern[edit source | edit]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit source | edit]
⊟Protein stability[edit source | edit]
- half-life: no data available
⊟Biological Material[edit source | edit]
⊟Mutants[edit source | edit]
⊟Expression vector[edit source | edit]
⊟lacZ fusion[edit source | edit]
⊟GFP fusion[edit source | edit]
⊟two-hybrid system[edit source | edit]
⊟FLAG-tag construct[edit source | edit]
⊟Antibody[edit source | edit]
⊟Other Information[edit source | edit]
You are kindly invited to share additional interesting facts.
⊟Literature[edit source | edit]
⊟References[edit source | edit]
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10
Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
J. Proteome Res.: 2011, 10(3);1139-50
[PubMed:21166474] [WorldCat.org] [DOI] (I p)
⊟Relevant publications[edit source | edit]