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NCBI: 02-MAR-2017

Summary[edit | edit source]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_RS03085 [old locus tag: NWMN_0535 ]
  • pan locus tag?: SAUPAN002349000
  • symbol: NWMN_RS03085
  • pan gene symbol?:
  • synonym:
  • product: HAD family hydrolase

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: NWMN_RS03085 [old locus tag: NWMN_0535 ]
  • symbol: NWMN_RS03085
  • product: HAD family hydrolase
  • replicon: chromosome
  • strand: +
  • coordinates: 620544..621191
  • length: 648
  • essential: unknown other strains

Accession numbers[edit | edit source]

  • Location: NC_009641 (620544..621191) NCBI
  • BioCyc:
  • MicrobesOnline: see NWMN_0535

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    TTGAAGTTTGACAATTATATTTTTGATTTTGATGGTACGTTGGCAGACACGAAAAAATGT
    GGTGAAGTAGCAACACAAAGTGCATTTAAAGCATGTGGCTTAACGGAACCATCATCTAAA
    GAAATAACGCATTATATGGGAATACCTATTGAAGAATCATTTTTAAAATTAGCAGACCGA
    CCATTAGATGAAGCAGCATTAGCAAAGTTAATCGATACATTTAGACATACATATCAATCT
    ATTGAAAAGGACTATATTTATGAATTTGCGGGTATAACTGAAGCCATTACAAGTTTGTAT
    AACCAAGGGAAAAAACTTTTCGTGGTGTCTAGTAAGAAGAGTGATGTATTAGAAAGAAAT
    TTATCGGCTATTGGATTAAATCACTTGATTACCGAAGCTGTTGGATCCGATCAAGTAAGT
    GCATATAAACCAAATCCTGAAGGCATACACACAATTGTGCAACGCTACAATTTAAATAGC
    CAACAAACGGTGTATATTGGTGATTCAACGTTTGATGTTGAGATGGCACAACGTGCTGGT
    ATGCAATCTGCAGCTGTCACTTGGGGTGCACATGATGCAAGGTCATTACTTCATTCAAAT
    CCGGATTTTATTATTAATGATCCATCAGAAATTAATACCGTATTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    648

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: NWMN_RS03085 [old locus tag: NWMN_0535 ]
  • symbol: NWMN_RS03085
  • description: HAD family hydrolase
  • length: 215
  • theoretical pI: 4.79367
  • theoretical MW: 23866.6
  • GRAVY: -0.26186

Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism Sugars phosphoglycolate phosphatase, bacterial (TIGR01449; EC 3.1.3.18; HMM-score: 94)
    AHBA synthesis associated protein (TIGR01454; HMM-score: 77.9)
    and 35 more
    HAD hydrolase, TIGR02253 family (TIGR02253; HMM-score: 69.3)
    phosphonatase-like hydrolase (TIGR03351; HMM-score: 66.4)
    beta-phosphoglucomutase family hydrolase (TIGR02009; HMM-score: 57)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 52.6)
    HAD hydrolase, REG-2-like, family IA (TIGR02252; HMM-score: 48.3)
    haloacid dehalogenase, type II (TIGR01428; EC 3.8.1.2; HMM-score: 46.4)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 1 (TIGR01549; HMM-score: 44.6)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides beta-phosphoglucomutase (TIGR01990; EC 5.4.2.6; HMM-score: 41.5)
    noncanonical pyrimidine nucleotidase, YjjG family (TIGR02254; EC 3.1.3.5; HMM-score: 38.6)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 3 (TIGR01509; HMM-score: 34.1)
    HAD hydrolase, TIGR01548 family (TIGR01548; HMM-score: 33.7)
    Metabolism Central intermediary metabolism Other phosphonoacetaldehyde hydrolase (TIGR01422; EC 3.11.1.1; HMM-score: 32)
    histidinol-phosphate phosphatase domain (TIGR01656; HMM-score: 29.9)
    Metabolism Amino acid biosynthesis Serine family phosphoserine phosphatase SerB (TIGR00338; EC 3.1.3.3; HMM-score: 29.2)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family (TIGR01670; EC 3.1.3.45; HMM-score: 27.1)
    Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 26.1)
    HAD phosphatase, family IIIC (TIGR01681; HMM-score: 25.3)
    Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 24.2)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 24.1)
    phosphoglycolate/pyridoxal phosphate phosphatase family (TIGR01452; EC 3.1.3.18; HMM-score: 23.4)
    HAD phosphatase, family IIIA (TIGR01668; EC 3.1.3.-; HMM-score: 23.2)
    pyrimidine 5'-nucleotidase (TIGR01993; EC 3.1.3.5; HMM-score: 22.7)
    phosphoglycolate phosphatase, TA0175-type (TIGR01487; EC 3.1.3.18; HMM-score: 19.8)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIA (TIGR01460; HMM-score: 19.2)
    FkbH domain (TIGR01686; HMM-score: 18.7)
    DNA 3'-phosphatase (TIGR01664; EC 3.1.3.32; HMM-score: 18.2)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IB (TIGR01490; HMM-score: 17.3)
    Metabolism Central intermediary metabolism Other 2,3-diketo-5-methylthio-1-phosphopentane phosphatase (TIGR01489; HMM-score: 16.9)
    HAD hydrolase, TIGR01459 family (TIGR01459; HMM-score: 16)
    epoxide hydrolase N-terminal domain-like phosphatase (TIGR02247; HMM-score: 14.6)
    phosphoserine phosphatase-like hydrolase, archaeal (TIGR01491; HMM-score: 14.2)
    Unknown function Enzymes of unknown specificity HAD hydrolase, TIGR01458 family (TIGR01458; HMM-score: 13.8)
    HAD hydrolase, family IA, variant 2 (TIGR01493; HMM-score: 13)
    Metabolism Amino acid biosynthesis Histidine family histidinol-phosphatase (TIGR01261; EC 3.1.3.15; HMM-score: 12.5)
    sucrose-phosphate phosphatase subfamily (TIGR01482; EC 3.1.3.-; HMM-score: 12.3)
  • TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
  • PFAM:
    HAD (CL0137) HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 153.8)
    and 5 more
    Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 51.3)
    Hydrolase_like; HAD-hyrolase-like (PF13242; HMM-score: 49.6)
    HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 37.9)
    Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 29.5)
    PNK3P; Polynucleotide kinase 3 phosphatase (PF08645; HMM-score: 15.2)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.012731
    • TAT(Tat/SPI): 0.000669
    • LIPO(Sec/SPII): 0.010902
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MKFDNYIFDFDGTLADTKKCGEVATQSAFKACGLTEPSSKEITHYMGIPIEESFLKLADRPLDEAALAKLIDTFRHTYQSIEKDYIYEFAGITEAITSLYNQGKKLFVVSSKKSDVLERNLSAIGLNHLITEAVGSDQVSAYKPNPEGIHTIVQRYNLNSQQTVYIGDSTFDVEMAQRAGMQSAAVTWGAHDARSLLHSNPDFIINDPSEINTVL

Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]