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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_RS04575 [old locus tag: NWMN_0809 ]
  • pan locus tag?: SAUPAN003037000
  • symbol: NWMN_RS04575
  • pan gene symbol?:
  • synonym:
  • product: NADH dehydrogenase family protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_RS04575 [old locus tag: NWMN_0809 ]
  • symbol: NWMN_RS04575
  • product: NADH dehydrogenase family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 896147..897211
  • length: 1065
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_009641 (896147..897211) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
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    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAAAAACTTAGTTTTGTTAGGCGGCGGATATGGTAATATGCGTATCATGTCACGCATT
    TTAACTACTTCTTTACCACAAGATTATACAGTCACATTAGTTGATCGTATGCCATTTCAT
    GGATTGAAACCAGAATTTTATGCTTTAGCTGCGGGCACGAAATCAGATAAAGATGTTCGT
    ATGAAATTCCCTAATCATCCACAAGTGAATACAGTTTATGGTGAAATTAACGACATAGAT
    TTAGATGCTCAAATTGTCTCAGTCGGTAATTCTAAAATTGATTATGATGAGCTAATCATT
    GGTTTAGGATGTGAAGATAAATATCATAACGTTCCAGGAGCCGAAGAATATACACATAGT
    ATTCAAACACTCTCAAAGGCTCGGGATACTTTCCATAGTATTAGTGAACTACCAGAAGGT
    GCTAAAGTCGGTATCGTTGGTGCTGGATTAAGCGGCATAGAACTTGCCAGCGAATTAAGA
    GAAAGTAGATCAGACTTGGAAATATATCTTTATGACCGTGGGCCGCGAATTTTAAGAAAT
    TTTCCAGAAAAATTAAGTAAGTATGTTGCGAAATGGTTCGCCAAAAATAATGTTACCGTT
    GTTCCAAATTCAAATATTAATAAAGTTGAACCTGGTAAAATATATAACTGTGATGAACCT
    AAAGATATTGATTTAGTTGTATGGACAGCAGGAATTCAACCTGTTGAAGTTGTTCGTAAC
    TTGCCGATTGATATAAATAGTAATGGACGCGTGATAGTTAACCAGTATCATCAAGTACCA
    ACATATCGTAACGTCTATGTAGTTGGTGATTGTGCTGATTTACCACATGCGCCAAGTGCT
    CAGTTAGCCGAAGTTCAAGGTGATCAAATTGCCGATGTGCTTAAAAAGCAATGGCTAAAT
    GAACCATTACCTGACAAAATGCCGGAACTAAAGGTACAAGGTATCGTTGGGTCATTAGGA
    GATAAGCAAGGTTTTGCATATATCATGGACCGCACTGTAACAGGACGACTCGCTTCTATT
    TTAAAATCCGGCGTACTTTGGTTATATAAATATCATAATGGTTAA
    60
    120
    180
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    1020
    1065

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_RS04575 [old locus tag: NWMN_0809 ]
  • symbol: NWMN_RS04575
  • description: NADH dehydrogenase family protein
  • length: 354
  • theoretical pI: 6.31904
  • theoretical MW: 39398.7
  • GRAVY: -0.272034

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    pyridine nucleotide-disulfide oxidoreductase family protein (TIGR03169; HMM-score: 107.7)
    Cellular processesCellular processesDetoxificationCoA-disulfide reductase (TIGR03385; EC 1.8.1.14; HMM-score: 70)
    oxidoreductase/SelD-related fusion protein (TIGR04369; HMM-score: 60.9)
    MetabolismEnergy metabolismElectron transportglutathione-disulfide reductase (TIGR01421; EC 1.8.1.7; HMM-score: 57.6)
    dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 55)
    MetabolismCentral intermediary metabolismNitrogen metabolismnitrite reductase [NAD(P)H], large subunit (TIGR02374; EC 1.7.1.4; HMM-score: 45.5)
    Cellular processesCellular processesDetoxificationmercury(II) reductase (TIGR02053; EC 1.16.1.1; HMM-score: 42.5)
    MetabolismEnergy metabolismElectron transportglutathione-disulfide reductase (TIGR01424; EC 1.8.1.7; HMM-score: 32)
    trypanothione-disulfide reductase (TIGR01423; EC 1.8.1.12; HMM-score: 20.1)
    Cellular processesCellular processesDetoxificationalkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 14.3)
    Cellular processesCellular processesAdaptations to atypical conditionsalkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 14.3)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersHeme, porphyrin, and cobalaminprotoporphyrinogen oxidase (TIGR00562; EC 1.3.3.4; HMM-score: 14.1)
    putative selenate reductase, YgfK subunit (TIGR03315; HMM-score: 13)
    glutamate synthase, small subunit (TIGR01318; HMM-score: 11.6)
  • TheSEED:
  • PFAM:
    NADP_Rossmann (CL0063) Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 134)
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 49.4)
    Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase (PF13738; HMM-score: 25.3)
    K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring) (PF13434; HMM-score: 20.7)
    NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 19.5)
    NAD_binding_9; FAD-NAD(P)-binding (PF13454; HMM-score: 18.2)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 17.1)
    Lycopene_cycl; Lycopene cyclase protein (PF05834; HMM-score: 14.8)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 12.6)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.159
    • Ymax_pos: 13
    • Cmax: 0.15
    • Cmax_pos: 51
    • Smax: 0.332
    • Smax_pos: 6
    • Smean: 0.25
    • D: 0.194
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

  • GI: 446716706 NCBI
  • RefSeq: WP_000794020 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MKNLVLLGGGYGNMRIMSRILTTSLPQDYTVTLVDRMPFHGLKPEFYALAAGTKSDKDVRMKFPNHPQVNTVYGEINDIDLDAQIVSVGNSKIDYDELIIGLGCEDKYHNVPGAEEYTHSIQTLSKARDTFHSISELPEGAKVGIVGAGLSGIELASELRESRSDLEIYLYDRGPRILRNFPEKLSKYVAKWFAKNNVTVVPNSNINKVEPGKIYNCDEPKDIDLVVWTAGIQPVEVVRNLPIDINSNGRVIVNQYHQVPTYRNVYVVGDCADLPHAPSAQLAEVQGDQIADVLKKQWLNEPLPDKMPELKVQGIVGSLGDKQGFAYIMDRTVTGRLASILKSGVLWLYKYHNG

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • NWMN_RS04575 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]