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NCBI: 26-AUG-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus N315
  • locus tag: SA0551 [new locus tag: SA_RS03185 ]
  • pan locus tag?: SAUPAN002375000
  • symbol: SA0551
  • pan gene symbol?:
  • synonym:
  • product: hypothetical protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SA0551 [new locus tag: SA_RS03185 ]
  • symbol: SA0551
  • product: hypothetical protein
  • replicon: chromosome
  • strand: -
  • coordinates: 644319..645767
  • length: 1449
  • essential: no DEG other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    TTGCTCGTAATATTGCAACTACCATGTCACATTATCAGCAAGACGAACAGAATATCATTA
    TTAATTTTTATAATGAAAAAACAATCAAAGATGTCATTGAAGACATTCAAAAGGAGGATT
    TATGTCATGAAAACATATGATTTAATTGTAATAGGATTTGGGAAAGCTGGTAAAACTTTA
    GCGAAATATGCTGCATCAACAGGTCAACACGTCGCAGTTATCGAACAATCTTCGAAAATG
    TATGGCGGCACTTGTATAAATATAGGATGTATACCTTCGAAGACACTTGTACATGATGGA
    TTAGAAGGCAAATCTTTTGAAGCAAGTTATAACCGTAAAAACGATGTTGTCAATGCGCTA
    AACAATAAAAATTACCACTTATTAGCAGACGATAACAACATTGATGTATTGGATTTTAAA
    GCGCAGTTTAAATCTAATACTGAAGTGAATTTATTAGATCAGCATGGCGATATCGTCGAT
    AGTATTACTGCACCTCATATCATTATTAATACCGGTGCTACCTCTATCATTCCTAACATA
    AAAGGCCTTGATCAAGCTAAACATGTCTTCGATTCAACAGGTTTATTAAACATTAGCTAT
    CAACCTAAGCATCTCGTTATTGTAGGTGGCGGTTATATTGCCTTAGAATTTGCTTCAATG
    TTTGCGAATTTAGGTAGTAAGGTAACAGTATTAGAACGTGGTGAATCATTTATGCCACGC
    GAAGATCAAGATGTCGTTGCACATGCTATTACTGACTTAGAAAATAAAGGCATTGCATTG
    CATACAAATGTTGAAACGACTGAATTGTCATCTGACGATCATCATACAACAGTCCGTACT
    AATGTTGGCAACTTTGAGGCTGATGCAGTACTTTTGGCTATCGGGCGCAAACCGAATACA
    GCCTTAGCTTTAGAAAATACTGATATCGAATTAGGTGATAGAGGCGAAATTAAAGTCAAT
    GCTCAACTTCAAACATCTGTGCCACATATTTATGCTGCAGGTGATGTTAAAGGCGGACTT
    CAATTTACGTATATATCTTTAGATGATTATCGAATTATCAAATCAGCGTTATATGGTAAT
    CAGTCACGTACGACTGACAATAGAGGTAGCGTGCCTTATACAGTATTTATAGATCCACCA
    TTATCACGTGTTGGATTAACTAGTAAAGAAGCTGCCGCTCAACATTATGATTACACTGAA
    CATCAACTTTTAGTAAGTGCTATACCTCGTCACAAAATTAACAATGATCCAAGAGGTTTA
    TTTAAAGTAGTCATTAATAATGAAAATAATATGATTTTAGGTGCTACATTATATGGTAAG
    CAATCTGAAGAATTAATTAATATAATTAAACTTGCGATTGATCAAAACATTCCATATACC
    GTATTACGAGATAATATTTATACACATCCTACGATGGCCGAATCATTTAATGATTTATTT
    AATTTCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1449

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SA0551 [new locus tag: SA_RS03185 ]
  • symbol: SA0551
  • description: hypothetical protein
  • length: 482
  • theoretical pI: 6.99987
  • theoretical MW: 53318.4
  • GRAVY: -0.15249

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 321)
    Cellular processesCellular processesDetoxificationmercury(II) reductase (TIGR02053; EC 1.16.1.1; HMM-score: 305.4)
    MetabolismEnergy metabolismElectron transportglutathione-disulfide reductase (TIGR01424; EC 1.8.1.7; HMM-score: 243.9)
    mycothione reductase (TIGR03452; EC 1.8.1.15; HMM-score: 204.7)
    MetabolismEnergy metabolismElectron transportglutathione-disulfide reductase (TIGR01421; EC 1.8.1.7; HMM-score: 200.8)
    thioredoxin and glutathione reductase (TIGR01438; EC 1.6.4.-; HMM-score: 161.2)
    trypanothione-disulfide reductase (TIGR01423; EC 1.8.1.12; HMM-score: 148.6)
    Cellular processesCellular processesDetoxificationCoA-disulfide reductase (TIGR03385; EC 1.8.1.14; HMM-score: 122.6)
    MetabolismCentral intermediary metabolismNitrogen metabolismnitrite reductase [NAD(P)H], large subunit (TIGR02374; EC 1.7.1.4; HMM-score: 92.7)
    MetabolismEnergy metabolismElectron transportthioredoxin-disulfide reductase (TIGR01292; EC 1.8.1.9; HMM-score: 78.6)
    Cellular processesCellular processesDetoxificationalkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 67.1)
    Cellular processesCellular processesAdaptations to atypical conditionsalkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 67.1)
    MetabolismAmino acid biosynthesisGlutamate familyglutamate synthase (NADPH), homotetrameric (TIGR01316; EC 1.4.1.13; HMM-score: 60.2)
    pyridine nucleotide-disulfide oxidoreductase family protein (TIGR03169; HMM-score: 52.9)
    putative alkyl hydroperoxide reductase F subunit (TIGR03143; EC 1.6.4.-; HMM-score: 49.9)
    Unknown functionEnzymes of unknown specificityputative bacillithiol system oxidoreductase, YpdA family (TIGR04018; EC 1.8.-.-; HMM-score: 49.2)
    putative selenate reductase, YgfK subunit (TIGR03315; HMM-score: 40)
    Unknown functionEnzymes of unknown specificityflavoprotein, HI0933 family (TIGR00275; HMM-score: 38)
    FAD dependent oxidoreductase TIGR03364 (TIGR03364; HMM-score: 37.9)
    glutamate synthase, NADH/NADPH, small subunit (TIGR01317; EC 1.4.1.-; HMM-score: 34)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersChlorophyll and bacteriochlorphyllgeranylgeranyl reductase family (TIGR02032; EC 1.3.1.-; HMM-score: 34)
    glutamate synthase, small subunit (TIGR01318; HMM-score: 31.9)
    mycofactocin system FadH/OYE family oxidoreductase 2 (TIGR03997; EC 1.-.-.-; HMM-score: 28)
    Genetic information processingProtein synthesistRNA and rRNA base modificationtRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain (TIGR03197; HMM-score: 26)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersThiaminethiazole biosynthesis enzyme (TIGR00292; HMM-score: 25.4)
    Genetic information processingProtein fateProtein folding and stabilizationxanthine dehydrogenase accessory protein XdhC (TIGR02964; HMM-score: 22.4)
    MetabolismPurines, pyrimidines, nucleosides, and nucleotidesOtherxanthine dehydrogenase accessory protein XdhC (TIGR02964; HMM-score: 22.4)
    squalene-associated FAD-dependent desaturase (TIGR03467; HMM-score: 19.8)
    Cell structureCell envelopeBiosynthesis and degradation of surface polysaccharides and lipopolysaccharidesUDP-galactopyranose mutase (TIGR00031; EC 5.4.99.9; HMM-score: 18.4)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersThiamineglycine oxidase ThiO (TIGR02352; EC 1.4.3.19; HMM-score: 17.5)
    nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 17.3)
    Cellular processesCellular processesSporulation and germinationdipicolinic acid synthetase, A subunit (TIGR02853; HMM-score: 17.2)
    mycofactocin system FadH/OYE family oxidoreductase 1 (TIGR03996; EC 1.-.-.-; HMM-score: 15.9)
    MetabolismAmino acid biosynthesisOtherpyrrolysine biosynthesis protein PylD (TIGR03911; HMM-score: 15.2)
    MetabolismEnergy metabolismElectron transportflavocytochrome c (TIGR01813; HMM-score: 14.9)
    MetabolismPurines, pyrimidines, nucleosides, and nucleotidesNucleotide and nucleoside interconversionsputative uridylate kinase (TIGR02076; EC 2.7.4.-; HMM-score: 14.9)
    MetabolismEnergy metabolismAmino acids and aminessarcosine oxidase, alpha subunit family (TIGR01372; HMM-score: 14.7)
    MetabolismEnergy metabolismAmino acids and aminesalanine dehydrogenase (TIGR00518; EC 1.4.1.1; HMM-score: 14.3)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersOtherC-3',4' desaturase CrtD (TIGR02733; EC 1.3.99.-; HMM-score: 13.6)
    MetabolismEnergy metabolismAmino acids and aminessarcosine oxidase, beta subunit family (TIGR01373; HMM-score: 12.2)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersOtherphytoene desaturase (TIGR02734; EC 1.14.99.-; HMM-score: 11.2)
    lycopene cyclase family protein (TIGR01790; HMM-score: 10.7)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersMenaquinone and ubiquinoneubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family (TIGR01988; EC 1.14.13.-; HMM-score: 9.5)
  • TheSEED:  
    CarbohydratesCentral carbohydrate metabolismTCA Cycle Putative Dihydrolipoamide dehydrogenase (EC 1.8.1.4) 
    Virulence, Disease and DefenseResistance to antibiotics and toxic compoundsMercuric reductase Mercuric ion reductase (EC 1.16.1.1) 
    Resistance to antibiotics and toxic compoundsMercuric reductase PF00070 family, FAD-dependent NAD(P)-disulphide oxidoreductase 
    Resistance to antibiotics and toxic compoundsMercury resistance operon Mercuric ion reductase (EC 1.16.1.1) 
  • PFAM:
    NADP_Rossmann (CL0063) Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 204.6)
    Reductase_C (CL0608) Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain (PF02852; HMM-score: 81.7)
    NADP_Rossmann (CL0063) Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 81)
    Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase (PF13738; HMM-score: 52.2)
    HI0933_like; HI0933-like protein (PF03486; HMM-score: 33.8)
    K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring) (PF13434; HMM-score: 28.6)
    NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 27.4)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 26.2)
    XdhC_C; XdhC Rossmann domain (PF13478; HMM-score: 26)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 24.7)
    TrkA_N; TrkA-N domain (PF02254; HMM-score: 23)
    Thi4; Thi4 family (PF01946; HMM-score: 22.9)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 22.3)
    NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 21.7)
    GIDA; Glucose inhibited division protein A (PF01134; HMM-score: 21.3)
    AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 20.3)
    Lycopene_cycl; Lycopene cyclase protein (PF05834; HMM-score: 19.8)
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 16.2)
    FAD_binding_2; FAD binding domain (PF00890; HMM-score: 15.9)
    UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 15.9)
    no clan definedDUF4147; Domain of unknown function (DUF4147) (PF13660; HMM-score: 13.4)
    NADP_Rossmann (CL0063) Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 12.2)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular Possibility: 1
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.194
    • Ymax_pos: 14
    • Cmax: 0.133
    • Cmax_pos: 32
    • Smax: 0.445
    • Smax_pos: 5
    • Smean: 0.338
    • D: 0.25
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MLVILQLPCHIISKTNRISLLIFIMKKQSKMSLKTFKRRIYVMKTYDLIVIGFGKAGKTLAKYAASTGQHVAVIEQSSKMYGGTCINIGCIPSKTLVHDGLEGKSFEASYNRKNDVVNALNNKNYHLLADDNNIDVLDFKAQFKSNTEVNLLDQHGDIVDSITAPHIIINTGATSIIPNIKGLDQAKHVFDSTGLLNISYQPKHLVIVGGGYIALEFASMFANLGSKVTVLERGESFMPREDQDVVAHAITDLENKGIALHTNVETTELSSDDHHTTVRTNVGNFEADAVLLAIGRKPNTALALENTDIELGDRGEIKVNAQLQTSVPHIYAAGDVKGGLQFTYISLDDYRIIKSALYGNQSRTTDNRGSVPYTVFIDPPLSRVGLTSKEAAAQHYDYTEHQLLVSAIPRHKINNDPRGLFKVVINNENNMILGATLYGKQSEELINIIKLAIDQNIPYTVLRDNIYTHPTMAESFNDLFNF

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]