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NCBI: 26-AUG-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus N315
  • locus tag: SA2068 [new locus tag: SA_RS11895 ]
  • pan locus tag?: SAUPAN005734000
  • symbol: moeA
  • pan gene symbol?: moeA
  • synonym:
  • product: molybdopterin biosynthesis protein moeA

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SA2068 [new locus tag: SA_RS11895 ]
  • symbol: moeA
  • product: molybdopterin biosynthesis protein moeA
  • replicon: chromosome
  • strand: -
  • coordinates: 2329481..2330740
  • length: 1260
  • essential: no DEG other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGGTAGTAGAAAAAAGAAACCCAATCCCAGTTAAAGAAGCAATTCAACGTATCGTTAAT
    CAGCAGAGTTCAATGCCGGCAATTACGGTAGCACTTGAAAAAAGTCTAAATCATATCTTA
    GCAGAAGATATTGTAGCTACTTATGATATACCAAGGTTTGATAAATCACCTTATGATGGT
    TTTGCAATTCGCAGTGTTGATTCACAAGGGGCAAGTGGTCAGAATCGCATTGAGTTTAAA
    GTGATTGATCATATTGGTGCAGGTTCAGTTTCTGATAAATTAGTTGGGGATCACGAAGCG
    GTGCGTATTATGACTGGAGCACAAATACCAAATGGCGCAGATGCTGTTGTTATGTTTGAA
    CAAACGATTGAACTAGAAGATACATTTACAATTCGTAAACCATTTTCAAAAAATGAAAAT
    ATATCTTTAAAAGGTGAAGAAACAAAGACAGGCGATGTTGTTCTAAAAAAAGGACAAGTA
    ATTAACCCAGGGGCTATCGCGGTCCTTGCAACATATGGCTATGCAGAGGTTAAAGTTATT
    AAGCAACCGAGTGTCGCTGTTATTGCAACAGGAAGCGAATTATTAGATGTTAATGATGTA
    TTAGAAGATGGAAAAATTCGTAACTCTAATGGCCCAATGATTCGTGCCTTAGCAGAAAAA
    TTAGGTCTTGAAGTTGGTATTTACAAAACACAAAAAGATGATTTAGATAGTGGCATCCAA
    GTCGTTAAAGAAGCTATGGAAAAACACGATATCGTTATTACAACGGGTGGAGTTTCTGTT
    GGAGACTTTGACTATTTACCTGAGATTTATAAGGCTGTAAAGGCGGAAGTGTTATTTAAT
    AAAGTAGCAATGCGTCCTGGTAGCGTAACAACGGTTGCATTTGCAGATGGAAAGTATTTG
    TTTGGATTATCTGGAAATCCATCAGCTTGTTTTACAGGATTTGAACTATTTGTGAAACCA
    GCTGTTAAACATATGTGTGGCGCACTAGAAGTCTTCCCGCAAATAATTAAAGCAACATTA
    ATGGAAGATTTTACCAAGGCAAACCCATTCACACGATTTATACGTGCTAAAGCAACGTTA
    ACAAGTGCTGGAGCTACTGTAGTACCTTCAGGATTCAATAAATCAGGTGCGGTTGTAGCG
    ATTGCACATGCTAACTGTATGGTCATGTTACCAGGAGGGTCACGTGGTTTTAAAGCGGGG
    CATACAGTAGATATTATATTGACTGAATCTGACGCTGCTGAAGAGGAACTTCTTTTATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SA2068 [new locus tag: SA_RS11895 ]
  • symbol: MoeA
  • description: molybdopterin biosynthesis protein moeA
  • length: 419
  • theoretical pI: 5.50634
  • theoretical MW: 44988.5
  • GRAVY: 0.05179

Function[edit source | edit]

  • reaction:
    EC 2.10.1.1?  ExPASy
    Molybdopterin molybdotransferaseAdenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP
  • TIGRFAM:
    molybdenum cofactor synthesis domain (TIGR00177; HMM-score: 112.7)
    Genetic information processingDNA metabolismDNA replication, recombination, and repaircompetence/damage-inducible protein CinA N-terminal domain (TIGR00200; HMM-score: 23.9)
  • TheSEED:  
    Molybdenum cofactor biosynthesis Molybdopterin molybdenumtransferase (EC 2.10.1.1) 
  • PFAM:
    no clan definedMoeA_N; MoeA N-terminal region (domain I and II) (PF03453; HMM-score: 139.4)
    MoCF_biosynth; Probable molybdopterin binding domain (PF00994; HMM-score: 93.1)
    MoeA_C; MoeA C-terminal region (domain IV) (PF03454; HMM-score: 59.9)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors: Mg2+
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular Possibility: 1
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.161
    • Ymax_pos: 42
    • Cmax: 0.184
    • Cmax_pos: 42
    • Smax: 0.263
    • Smax_pos: 22
    • Smean: 0.152
    • D: 0.158
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETKTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQKDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]

Alexander Scherl, Patrice François, Manuela Bento, Jacques M Deshusses, Yvan Charbonnier, Véronique Converset, Antoine Huyghe, Nadia Walter, Christine Hoogland, Ron D Appel, Jean-Charles Sanchez, Catherine G Zimmermann-Ivol, Garry L Corthals, Denis F Hochstrasser, Jacques Schrenzel
Correlation of proteomic and transcriptomic profiles of Staphylococcus aureus during the post-exponential phase of growth.
J. Microbiol. Methods: 2005, 60(2);247-57
[PubMed:15590099] [WorldCat.org] [DOI] (P p)