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NCBI: 10-JUN-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1368 [new locus tag: SACOL_RS06965 ]
  • pan locus tag?: SAUPAN003707000
  • symbol: kataA
  • pan gene symbol?: katA
  • synonym:
  • product: catalase

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SACOL1368 [new locus tag: SACOL_RS06965 ]
  • symbol: kataA
  • product: catalase
  • replicon: chromosome
  • strand: +
  • coordinates: 1373896..1375317
  • length: 1422
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGCAAGATATTTACTTTTTAGAGCAAATGTCTCAATTTGATAGAGAAGTAATACCAGAA
    CGTCGAATGCATGCCAAAGGTTCTGGTGCATTTGGGACATTTACTGTAACTAAAGATATA
    ACAAAATATACGAATGCTAAAATATTCTCTGAAATAGGTAAGCAAACCGAAATGTTTGCC
    CGTTTCTCTACTGTAGCAGGAGAACGTGGTGCTGCTGATGCGGAGCGTGACATTCGAGGA
    TTTGCGTTAAAGTTCTACACTGAAGAAGGGAACTGGGATTTAGTAGGGAATAACACACCA
    GTATTCTTCTTTAGAGATCCAAAGTTATTTGTTAGTTTAAATCGTGCGGTGAAACGAGAT
    CCTAGAACAAATATGAGAGATGCACAAAATAACTGGGATTTCTGGACGGGTCTTCCAGAA
    GCATTGCACCAAGTAACGATCTTAATGTCAGATAGAGGGATTCCTAAAGATTTACGTCAT
    ATGCATGGGTTCGGTTCTCACACATACTCTATGTATAATGATTCTGGTGAACGTGTTTGG
    GTTAAATTCCATTTTAGAACGCAACAAGGTATTGAAAACTTAACTGATGAAGAAGCTGCT
    GAAATTATAGCTACAGATCGTGATTCATCTCAACGCGATTTATTCGAAGCCATTGAAAAA
    GGTGATTATCCAAAATGGACAATGTATATTCAAGTAATGACTGAGGAACAAGCTAAAAAC
    CATAAAGATAATCCATTTGATTTAACAAAAGTATGGTATCACGATGAGTATCCTCTAATT
    GAAGTTGGAGAGTTTGAATTAAATAGAAATCCAGATAATTACTTTATGGATGTTGAACAA
    GCTGCGTTTGCACCAACTAATATTATTCCAGGATTAGATTTTTCTCCAGACAAAATGCTG
    CAAGGGCGTTTATTCTCATATGGCGATGCGCAAAGATATCGATTAGGAGTTAATCATTGG
    CAGATTCCTGTAAACCAACCTAAAGGTGTTGGTATTGAAAATATTTGTCCTTTTAGTAGA
    GATGGTCAAATGCGCGTAGTTGACAATAACCAAGGTGGAGGAACACATTATTATCCAAAT
    AACCATGGTAAATTTGATTCTCAACCTGAATATAAAAAGCCACCATTCCCAACTGATGGA
    TACGGCTATGAATATAATCAACGTCAAGATGATGATAATTATTTTGAACAACCAGGTAAA
    TTGTTTAGATTACAATCAGAGGACGCTAAAGAAAGAATTTTTACAAATACAGCAAATGCA
    ATGGAAGGCGTAACGGATGATGTTAAACGACGTCATATTCGTCATTGTTACAAAGCTGAC
    CCAGAATATGGTAAAGGTGTTGCAAAAGCATTAGGTATTGATATAAATTCTATTGATCTT
    GAAACTGAAAATGATGAAACATACGAAAACTTTGAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1422

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL1368 [new locus tag: SACOL_RS06965 ]
  • symbol: KataA
  • description: catalase
  • length: 473
  • theoretical pI: 4.98236
  • theoretical MW: 54942.6
  • GRAVY: -0.854334

Function[edit source | edit]

  • reaction:
    EC 1.11.1.6?  ExPASy
    Catalase2 H2O2 = O2 + 2 H2O
  • TIGRFAM:
  • TheSEED:  
    Oxidative stress Catalase KatE (EC 1.11.1.6) 
    Protection from Reactive Oxygen Species Catalase KatE (EC 1.11.1.6) 
  • PFAM:
    no clan definedCatalase; Catalase (PF00199; HMM-score: 578.2)
    Catalase-rel; Catalase-related immune-responsive (PF06628; HMM-score: 80.5)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors: heme
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular Possibility: 1
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.131
    • Ymax_pos: 26
    • Cmax: 0.111
    • Cmax_pos: 40
    • Smax: 0.217
    • Smax_pos: 21
    • Smean: 0.123
    • D: 0.128
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MQDIYFLEQMSQFDREVIPERRMHAKGSGAFGTFTVTKDITKYTNAKIFSEIGKQTEMFARFSTVAGERGAADAERDIRGFALKFYTEEGNWDLVGNNTPVFFFRDPKLFVSLNRAVKRDPRTNMRDAQNNWDFWTGLPEALHQVTILMSDRGIPKDLRHMHGFGSHTYSMYNDSGERVWVKFHFRTQQGIENLTDEEAAEIIATDRDSSQRDLFEAIEKGDYPKWTMYIQVMTEEQAKNHKDNPFDLTKVWYHDEYPLIEVGEFELNRNPDNYFMDVEQAAFAPTNIIPGLDFSPDKMLQGRLFSYGDAQRYRLGVNHWQIPVNQPKGVGIENICPFSRDGQMRVVDNNQGGGTHYYPNNHGKFDSQPEYKKPPFPTDGYGYEYNQRQDDDNYFEQPGKLFRLQSEDAKERIFTNTANAMEGVTDDVKRRHIRHCYKADPEYGKGVAKALGIDINSIDLETENDETYENFEK

Experimental data[edit source | edit]

  • experimentally validated: PeptideAtlas
    experimental localization: Cytoplasmic [1] [2] [3] [4]
    quantitative data / protein copy number per cell: 5527 [5]

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulators: SACOL1919 (PerR*), CodY
    PerR* (TF) important in Oxidative stress response  RegPrecise
    CodY (TF) important in Amino acid metabolism  RegPrecise

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: 21.06 h [6]

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]