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NCBI: 10-JUN-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL2692
  • pan locus tag?: SAUPAN006414000
  • symbol: icaC
  • pan gene symbol?: icaC
  • synonym:
  • product:

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: pseudogene
  • locus tag: SACOL2692
  • symbol: icaC
  • product:
  • replicon: chromosome
  • strand: +
  • coordinates: 2765683..2766734
  • length: 1052
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAAAAAGATGAGACTTGAACTCGTATATTTACGTGCTATTATATGTGCAATTATTATT
    ATCACACATTTACTTACACAAATTACTTTAAAACATGAAAATATGGAGGGTGGATCCTTA
    GTGTTACAATTTTACATTCGTAATATTGTGATTTTTGGTACACCTTGCTTTATTATCTTG
    TCACAGTTACTGACAACCTTGAATTACCAAAAAGTCACCTATAGATACTTAACTACACGC
    GTAAAATATATACTTATTCCTTACATATTAATGGGATTGTTTTACAGTTATAGTGAATCA
    TTATTAACAGATTCAAGTTTCAATAAACAATTCATTGAAAATGTCCTATTAGGTCAATGG
    TATGGCTATTTTATCGTTGTTATCATGCAATTCTTTATTTTGAGTTATATCATTTTTAAA
    ATTAACTATAACCTATTCAACAGTAAAATATTATTATTGTTATCTTTTATTTTACAGCAA
    TCATTTTTATATTACTTTACGAACAACACAGCGTTTCACGATACCGTGCTACACTATTAT
    CCATTAAGTGAAAATACTATAATATTCGGATGGATTTTTTATTTCTTCTTAGGTGCATAT
    ATGGGTTATAACTACGAACGTGTATTAAATTTCTTAGAACGTTATTTAGTTATTATGATT
    GTATTAGCTGTAGCTACTTATTTTGTGTTTATTGCGTTAGCAAATGGAGACTATTGGAAC
    GTTACCAGCTTTTCATATTCATTAACACCATATAATAGTATTATGTTTATTGTTATCTTG
    GGTATTTGCACGCATTTTAAAACAATGTTATTTAATACGATTCAAATGATTAGTGCTTTC
    TCATTCTTTATTTATTTATTACATCCAATCATTCTAGACTCATTGTTTGCATATACAAAT
    ATATTTGAGATAATACAATGGTCTTTCTAGCGATATCACTACTATTCATTTTAGGATTAT
    GTATAGGTGTCGGCATGATATTGCGTGAATTCTATATCTTTAGGTTTATTATTGGAAAAC
    AACCATATAAATTGAACATTAATGCTTATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1052

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL2692
  • symbol: IcaC
  • description:
  • length: 0
  • theoretical pI:
  • theoretical MW:
  • GRAVY:

Function[edit source | edit]

  • TIGRFAM:
  • TheSEED:
  • PFAM:

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb:
  • LocateP:
  • SignalP:
  • predicted transmembrane helices (TMHMM):

Accession numbers[edit source | edit]

  • GI:
  • RefSeq:
  • UniProt:

Protein sequence[edit source | edit]

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulators: CodY (repression) regulon, IcaR (repression) regulon
    CodY(TF)important in Amino acid metabolismRegPrecise    transcription unit transferred from N315 data RegPrecise
    IcaR(TF)important in Intercellular adhesionRegPrecise    transcription unit transferred from N315 data RegPrecise

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]

Ursula Fluckiger, Martina Ulrich, Andrea Steinhuber, Gerd Döring, Dietrich Mack, Regine Landmann, Christiane Goerke, Christiane Wolz
Biofilm formation, icaADBC transcription, and polysaccharide intercellular adhesin synthesis by staphylococci in a device-related infection model.
Infect. Immun.: 2005, 73(3);1811-9
[PubMed:15731082] [WorldCat.org] [DOI] (P p)
C Heilmann, O Schweitzer, C Gerke, N Vanittanakom, D Mack, F Götz
Molecular basis of intercellular adhesion in the biofilm-forming Staphylococcus epidermidis.
Mol. Microbiol.: 1996, 20(5);1083-91
[PubMed:8809760] [WorldCat.org] (P p)