NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus COL
• locus tag: SACOL_RS14355
• pan locus tag^?:
• symbol: SACOL_RS14355
• pan gene symbol^?: —
• synonym:
• product: thiolase-like protein

⊟Gene

⊟General

• type: CDS
• locus tag: SACOL_RS14355
• symbol: SACOL_RS14355
• product: thiolase-like protein
• replicon: chromosome
• strand: +
• coordinates: 37063..37452
• length: 390
• essential: unknown

⊟Accession numbers

• Location: NC_002951 (37063..37452) NCBI
• MicrobesOnline:

⊟Phenotype

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⊟DNA sequence

• 1
  61
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  ATTCAACTTTGCAACAGAACCGTATTATGGAATAGAGATGTTGGTAACATTTATACAGGA
  TCATTATACTTAAGTTTAATTTCGTTATTACAGAACCACACATTCCAACCAGAAGAGAAA
  GTATGTCTATTTAGTTATGGTTCAGGAGCAGTAGGAGAAATCTTTAGTGGTTCAATCGTT
  AAAGGATATGACAAAGCATTAGATAAAGAGAAACACTTAAATATGCTAGAATCTAGAGAG
  CAATTATCAGTCGAAGAATACGAAACATTCTTTAACAGATTTGATAATCAAGAATTTGAT
  TTCGAACGTGAATTGACACAAGATCCATATTCAAAAGTATACTTATACAGTATAGAAGAC
  CATATCAGAACATATAAGATAGAGAAATAA
  60
  120
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  390
  

⊟Protein

⊟General

• locus tag: SACOL_RS14355
• symbol: SACOL_RS14355
• description: thiolase-like protein
• length: 129
• theoretical pI: 4.67252
• theoretical MW: 15244
• GRAVY: -0.53876

⊟Function

• reaction:
• TIGRFAM:
  hydroxymethylglutaryl-CoA synthase (TIGR01835; EC 2.3.3.10; HMM-score: 115.5)
  hydroxymethylglutaryl-CoA synthase (TIGR01833; EC 2.3.3.10; HMM-score: 44.8)
  MetabolismFatty acid and phospholipid metabolismBiosynthesisputative hydroxymethylglutaryl-CoA synthase (TIGR00748; EC 2.3.3.10; HMM-score: 16.9)
  hopanoid biosynthesis associated membrane protein HpnM (TIGR03481; HMM-score: 11.2)
• TheSEED:
• PFAM:
  Thiolase (CL0046) HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal (PF08540; HMM-score: 50)
  ACP_syn_III_C; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal (PF08541; HMM-score: 17)
  tRNA_synt_II (CL0040) tRNA-synt_2e; Glycyl-tRNA synthetase alpha subunit (PF02091; HMM-score: 13.1)

⊟Structure, modifications & interactions

• domains:
• modifications:
• cofactors:
• effectors:
• protein partners:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• LocateP:
• SignalP: no predicted signal peptide
  • Ymax: 0.191
  • Ymax_pos: 38
  • Cmax: 0.19
  • Cmax_pos: 38
  • Smax: 0.248
  • Smax_pos: 34
  • Smean: 0.141
  • D: 0.171
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_020444595 NCBI
• UniProt:

⊟Protein sequence

• MQLCNRTVLWNRDVGNIYTGSLYLSLISLLQNHTFQPEEKVCLFSYGSGAVGEIFSGSIVKGYDKALDKEKHLNMLESREQLSVEEYETFFNRFDNQEFDFERELTQDPYSKVYLYSIEDHIRTYKIEK

⊟Experimental data

• experimentally validated: no data available

⊟Expression & Regulation

⊟Operon

• SACOL_RS14355 no polycistronic organisation predicted

⊟Regulation

• sigma factor:
• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: no data available

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Other Information

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