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NCBI: 10-JUN-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus USA300_FPR3757
  • locus tag: SAUSA300_1628 [new locus tag: SAUSA300_RS08880 ]
  • pan locus tag?: SAUPAN004301000
  • symbol: lysP
  • pan gene symbol?: lysP
  • synonym:
  • product: lysine-specific permease

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SAUSA300_1628 [new locus tag: SAUSA300_RS08880 ]
  • symbol: lysP
  • product: lysine-specific permease
  • replicon: chromosome
  • strand: -
  • coordinates: 1780634..1782127
  • length: 1494
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    ATGTCAAAAGTTCAAAATGAAAGTAACAATGTTGTCAAAAGGGGACTTAAAGATCGTCAT
    ATTTCTATGATTGCGATTGGGGGTTGTATTGGTACAGGTTTATTTGTAACTTCTGGTGGA
    GCAATTCATGATGCAGGTGCTTTGGGTGCATTAATAGGATACGCAATTATCGGAATAATG
    GTATTTTTCTTAATGACGTCACTTGGCGAAATGGCTACGTATTTGCCAGTATCAGGTTCA
    TTTAGTACATATGCTACAAGATTTGTTGATCCATCTTTAGGGTTTGCGCTTGGTTGGAAC
    TATTGGTTTAACTGGGTAGTGACTGTAGCAGCAGATATTACGATTGCAGCACAAGTCATT
    CAATATTGGACACCATTGCAAGGCATACCCGCTTGGGCATGGAGTGCGTTGTTCTTAGTT
    ATAATTTTTAGTCTGAATTCGTTATCAGTTCGCGTCTATGGTGAAAGTGAATACTGGTTG
    GCATTGATAAAAGTGGTTACAGTTATTGTTTTCATTGCAATTGGTTTATTAACGATTGTC
    GGAATCATGGGTGGTCATGTTGTAGGATTCGAAATATTTAATAAAGGTGAAGGTCCAATT
    CTTGGTGGCAACTTAGGAGGAAGTTTGTTATCAATTCTAGGTGTATTCTTAATCGCTGGT
    TTCTCATTCCAAGGTACTGAGTTAATTGGTATTACGGCTGGTGAATCAGAAAATCCTGAA
    CGTGCTGTGCCGAAAGCAATTAAACAAGTATTCTGGAGAATTTTATTATTTTACATTTTA
    GCCATTTTTGTTATCGGTATGTTAATTCCTTATGATAGTAGTGCATTAATGGGGGGTAGT
    GATAATGTAGCAACGTCTCCATTCACATTAGTGTTTAAAAATGCTGGATTTGCGTTTGCA
    GCATCATTTATGAATGCAGTCATTTTAACGTCTGTGTTATCAGCAGGTAACTCAGGTATG
    TATGCTTCAACTCGAATGCTATATTCAATGAGTAAAGATAAATTAGCGTTTGAAGCATTT
    GGTAAAACAAATAAAAACGGTGTGCCATATATGTCGTTACTCGTTACAGCAATCATTGTA
    GTGATAATTTTCGTATTACAAAGCCTTACAAAAGGTGCATACGAATATATCGTTGCAGCA
    AGTGGTTTAACTGGTTTTATTGCTTGGGTAGGTATAGCAGTAAGTCATTATCGATTTAGA
    AGAGCATTTGATAAACAAAATTATGACAAATCTAAATTAAAATATACTGCTAAATTATTC
    CCATTCGGACCATTATTTGCTGGCTTTTTATGTATTGTAGTAATTATTGGTCAAGATGTT
    GACTTTATTAAAACAGGAGATTTTAATTTTAGTCGCTTCTTAATTACGTATATGGGAATT
    CCAGTATTTTTAGCATTCTTTATTTATCATAAGCTTCGATATAAAACGAAAAAAATTCCA
    TTAGAACAAGTAGATTTACGTCAAGACGTGTCAATGGATGAAATAAAAGGTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1494

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SAUSA300_1628 [new locus tag: SAUSA300_RS08880 ]
  • symbol: LysP
  • description: lysine-specific permease
  • length: 497
  • theoretical pI: 9.51176
  • theoretical MW: 54218.4
  • GRAVY: 0.655332

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesamino acid permease (yeast) (TIGR00913; HMM-score: 467.6)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesGABA permease (TIGR01773; HMM-score: 308.6)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesamino acid transporter (TIGR00909; HMM-score: 97.1)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminestransporter, basic amino acid/polyamine antiporter (APA) family (TIGR00905; HMM-score: 69.5)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesarginine-ornithine antiporter (TIGR03810; HMM-score: 56.1)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesethanolamine permease (TIGR00908; HMM-score: 53.2)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesL-type amino acid transporter (TIGR00911; HMM-score: 53.1)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminescationic amino acid transport permease (TIGR00906; HMM-score: 51.4)
    histidine-histamine antiporter (TIGR04298; HMM-score: 26.1)
    putative glutamate/gamma-aminobutyrate antiporter (TIGR03813; HMM-score: 14.3)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype VII secretion protein EssC (TIGR03928; HMM-score: 12)
  • TheSEED:  
    Lysine-specific permease 
  • PFAM:
    APC (CL0062) AA_permease; Amino acid permease (PF00324; HMM-score: 446.1)
    AA_permease_2; Amino acid permease (PF13520; HMM-score: 159.7)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 12
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: 0
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.179
    • Ymax_pos: 42
    • Cmax: 0.152
    • Cmax_pos: 48
    • Smax: 0.369
    • Smax_pos: 27
    • Smean: 0.218
    • D: 0.194
  • predicted transmembrane helices (TMHMM): 12

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MSKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIMVFFLMTSLGEMATYLPVSGSFSTYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVIQYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWLALIKVVTVIVFIAIGLLTIVGIMGGHVVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPERAVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGSDNVATSPFTLVFKNAGFAFAASFMNAVILTSVLSAGNSGMYASTRMLYSMSKDKLAFEAFGKTNKNGVPYMSLLVTAIIVVIIFVLQSLTKGAYEYIVAASGLTGFIAWVGIAVSHYRFRRAFDKQNYDKSKLKYTAKLFPFGPLFAGFLCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIPLEQVDLRQDVSMDEIKG

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]