NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus N315
• locus tag: SA_RS09180 [old locus tag: SA1631 ]
• pan locus tag^?: SAUPAN004567000
• symbol: SA_RS09180
• pan gene symbol^?: splA
• synonym:
• product: serine protease SplA

⊟Gene

⊟General

• type: CDS
• locus tag: SA_RS09180 [old locus tag: SA1631 ]
• symbol: SA_RS09180
• product: serine protease SplA
• replicon: chromosome
• strand: -
• coordinates: 1864410..1865117
• length: 708
• essential: unknown

⊟Accession numbers

• Location: NC_002745 (1864410..1865117) NCBI
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  ATGAATAAAAATGTAATGGTTAAAGGTTTAACTGCTTTAACTATTTTAACATCTCTTGGT
  TTCGCTGAAAATATTTCTAATCAGCCTCATTCAATTGCCAAAGCAGAAAAGAATGTCAAA
  GAAATTACCGATGCAACTAAGGCACCATACAATTCAGTGGTAGCATTTGCGGGTGGTACT
  GGTGTAGTTGTTGGTAAAAATACAATCGTAACTAACAAACATATCGCTAAAAGTAATGAT
  ATTTTTAAAAATAGAGTAGCAGCACATTATTCGAGTAAAGGTAAAGGCGGAGGAAACTAC
  GACGTTAAAGACATTGTAGAATATCCTGGAAAAGAAGACCTTGCGATAGTTCATGTTCAT
  GAAACAAGTACAGAAGGTTTGAATTTTAATAAGAACGTTAGTTATACAAAATTTGCAGAA
  GGAGCAAAAGCGAAAGATAGAATTTCTGTTATTGGTTATCCAAAGGGTGCACAAACAAAA
  TATAAAATGTTTGAATCGACAGGAACGATTAACCATATCAGTGGAACGTTTATAGAATTT
  GATGCGTATGCACAACCAGGTAATTCAGGATCTCCTGTATTGAATTCTAAACATGAACTG
  ATTGGTATTTTATATGCAGGTAGTGGAAAAGATGAATCTGAAAAGAATTTCGGTGTTTAT
  TTCACACCACAATTAAAAGAATTTATTCAAAATAATATTGAAAAATAA
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⊟Protein

⊟General

• locus tag: SA_RS09180 [old locus tag: SA1631 ]
• symbol: SA_RS09180
• description: serine protease SplA
• length: 235
• theoretical pI: 9.61883
• theoretical MW: 25440.5
• GRAVY: -0.398723

⊟Function

• reaction:
  EC 3.4.21.-?  ExPASy
• TIGRFAM:
  Genetic information processingProtein fateDegradation of proteins, peptides, and glycopeptidesperiplasmic serine peptidase DegS (TIGR02038; EC 3.4.21.-; HMM-score: 28.4)
  Signal transductionRegulatory functionsProtein interactionsperiplasmic serine peptidase DegS (TIGR02038; EC 3.4.21.-; HMM-score: 28.4)
  Genetic information processingProtein fateDegradation of proteins, peptides, and glycopeptidespeptidase Do (TIGR02037; EC 3.4.21.-; HMM-score: 25.2)
  Genetic information processingProtein fateProtein folding and stabilizationpeptidase Do (TIGR02037; EC 3.4.21.-; HMM-score: 25.2)
• TheSEED:
• PFAM:
  Peptidase_PA (CL0124) Trypsin; Trypsin (PF00089; HMM-score: 72.1)
  Trypsin_2; Trypsin-like peptidase domain (PF13365; HMM-score: 59.2)
  Peptidase_S46; Peptidase S46 (PF10459; HMM-score: 26.6)
  Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease (PF00949; HMM-score: 19.6)
  Peptidase_S32; Equine arteritis virus serine endopeptidase S32 (PF05579; HMM-score: 18.6)
  Peptidase_S39; Peptidase S39 (PF02122; HMM-score: 13.5)

⊟Structure, modifications & interactions

• domains:
• modifications:
• cofactors:
• effectors:
• protein partners:

⊟Localization

• PSORTb: Extracellular
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 0.09
  • Cellwall Score: 0.18
  • Extracellular Score: 9.73
  • Internal Helices: 0
• LocateP:
• SignalP: Signal peptide length 36 aa
  • Ymax: 0.424
  • Ymax_pos: 36
  • Cmax: 0.391
  • Cmax_pos: 36
  • Smax: 0.846
  • Smax_pos: 2
  • Smean: 0.645
  • D: 0.51
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446962171 NCBI
• RefSeq: WP_001039427 NCBI
• UniProt:

⊟Protein sequence

• MNKNVMVKGLTALTILTSLGFAENISNQPHSIAKAEKNVKEITDATKAPYNSVVAFAGGTGVVVGKNTIVTNKHIAKSNDIFKNRVAAHYSSKGKGGGNYDVKDIVEYPGKEDLAIVHVHETSTEGLNFNKNVSYTKFAEGAKAKDRISVIGYPKGAQTKYKMFESTGTINHISGTFIEFDAYAQPGNSGSPVLNSKHELIGILYAGSGKDESEKNFGVYFTPQLKEFIQNNIEK

⊟Experimental data

• experimentally validated: no data available

⊟Expression & Regulation

⊟Operon

• SA_RS09180 no polycistronic organisation predicted

⊟Regulation

• sigma factor:
• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: no data available

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Other Information

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