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PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_000040
  • pan locus tag?: SAUPAN000752000
  • symbol: JSNZ_000040
  • pan gene symbol?: —
  • synonym:
  • product: methyltransferase domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_000040
  • symbol: JSNZ_000040
  • product: methyltransferase domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 46335..47072
  • length: 738
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGTTCATGCAAAATAGAAATGATTTTATAGAAAAGCTATTAGACAGAGCTCAAATTGAA
    GAAGGCATGCGTGTACTGGATATAGGTTGTGCGACTGGTGAGGTCACTCAATTAATTGCA
    AAACGTGTGGGGACGAATGGTGAAGTCGTCGGTGTTGATGTGAATGAGTCATTACTTAAA
    ATCGCAAATGAAAACAATCAATATAACAATGTATCATATCAATCTTCTGATATATATCAA
    TTGCCAGAAACTATGGGGCATTTTGATGCGATTGTTGGTAGAAGAGTATTAATGTACTTA
    CCAGATGCTGAAAAGTGTTTACAAATTTTGAAATCAATTTTAAAACCTGAGGGTATATTA
    TGTTTTCAAGAAAGTGATGCTATTAACGCAGGTGTTGGTGCAGATACACTATCTTTACAT
    CAATCAGCAATTCAATGGATTTGGGAAACAGTGAAGCAAGAAGGTGGCAATATTCATATC
    GGTCAAAATTTATATAATTTGTTTAATAATAATGGAATGCATGTTGTAGATTATTTTGCA
    GAGGTAGTGATTCAAACATCAATGGACAATGATTTAGCATGGCTTGTAGATGTAATGCTA
    CAAAGAATGAAAGCACATGGTGTCATTAATGATGATTTTTCACTAGATGAGTTTAAATCA
    AACCTTGAACAAGAAGCAATAAACAATCAGTGTGCATTTATACGTGACATGGCATTTGGA
    ATTATCGGAAAAGCCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    738

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_000040
  • symbol: JSNZ_000040
  • description: methyltransferase domain-containing protein
  • length: 245
  • theoretical pI: 4.33163
  • theoretical MW: 27508.1
  • GRAVY: -0.123265

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 3-demethylubiquinone-9 3-O-methyltransferase (TIGR01983; EC 2.1.1.64; HMM-score: 52.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone demethylmenaquinone methyltransferase (TIGR02752; EC 2.1.1.163; HMM-score: 51.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin malonyl-acyl carrier protein O-methyltransferase BioC (TIGR02072; EC 2.1.1.-; HMM-score: 51.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll magnesium protoporphyrin O-methyltransferase (TIGR02021; EC 2.1.1.11; HMM-score: 48.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone/menaquinone biosynthesis methyltransferase (TIGR01934; EC 2.1.1.-; HMM-score: 44.7)
    and 22 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs putative 4-mercaptohistidine N1-methyltranferase (TIGR04345; HMM-score: 38.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit (TIGR02469; EC 2.1.1.132; HMM-score: 35.1)
    Genetic information processing Protein synthesis tRNA and rRNA base modification ribosomal RNA large subunit methyltransferase J (TIGR00438; EC 2.1.1.166; HMM-score: 34.4)
    Genetic information processing Protein fate Protein modification and repair protein-(glutamine-N5) methyltransferase, release factor-specific (TIGR03534; EC 2.1.1.-; HMM-score: 32.3)
    methyltransferase, FxLD system (TIGR04364; HMM-score: 31.7)
    methyltransferase, Rta_06860 family (TIGR04290; EC 2.1.1.-; HMM-score: 30.2)
    Genetic information processing Protein fate Protein modification and repair protein-L-isoaspartate O-methyltransferase (TIGR00080; EC 2.1.1.77; HMM-score: 29.4)
    methyltransferase, ATP-grasp peptide maturase system (TIGR04188; HMM-score: 27.4)
    Unknown function Enzymes of unknown specificity putative methylase (TIGR00537; HMM-score: 23.2)
    Genetic information processing Protein synthesis tRNA and rRNA base modification ribosomal RNA small subunit methyltransferase A (TIGR00755; EC 2.1.1.182; HMM-score: 22.4)
    Genetic information processing Protein synthesis tRNA and rRNA base modification NOL1/NOP2/sun family putative RNA methylase (TIGR00446; EC 2.1.1.-; HMM-score: 20.7)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 23S rRNA (uracil-5-)-methyltransferase RumA (TIGR00479; EC 2.1.1.-; HMM-score: 20.5)
    Unknown function Enzymes of unknown specificity tRNA (mo5U34)-methyltransferase (TIGR00452; EC 2.1.1.-; HMM-score: 20.2)
    Genetic information processing Protein fate Protein modification and repair methyltransferase, HemK family (TIGR00536; HMM-score: 20.2)
    Metabolism Amino acid biosynthesis Aspartate family methionine biosynthesis protein MetW (TIGR02081; HMM-score: 19.8)
    Unknown function Enzymes of unknown specificity tRNA (cmo5U34)-methyltransferase (TIGR00740; EC 2.1.1.-; HMM-score: 17.6)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific (TIGR03533; EC 2.1.1.-; HMM-score: 16.5)
    Genetic information processing Transcription RNA processing 3' terminal RNA ribose 2'-O-methyltransferase Hen1 (TIGR04074; EC 2.1.1.-; HMM-score: 15.9)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 3' terminal RNA ribose 2'-O-methyltransferase Hen1 (TIGR04074; EC 2.1.1.-; HMM-score: 15.9)
    methyltransferase, FkbM family (TIGR01444; HMM-score: 15.5)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides putative sugar O-methyltransferase (TIGR04371; EC 2.1.1.-; HMM-score: 14.5)
    Hypothetical proteins Conserved putative methyltransferase, TIGR01177 family (TIGR01177; HMM-score: 12.8)
  • TheSEED:
  • PFAM:
    NADP_Rossmann (CL0063) Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 97.6)
    and 27 more
    Methyltransf_23; Methyltransferase domain (PF13489; HMM-score: 73.3)
    Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 70.8)
    Methyltransf_11; Methyltransferase domain (PF08241; HMM-score: 67.1)
    Methyltransf_12; Methyltransferase domain (PF08242; HMM-score: 57.7)
    Ubie_methyltran; ubiE/COQ5 methyltransferase family (PF01209; HMM-score: 53.8)
    FtsJ; FtsJ-like methyltransferase (PF01728; HMM-score: 41.6)
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) (PF01135; HMM-score: 37.5)
    NodS; Nodulation protein S (NodS) (PF05401; HMM-score: 34.7)
    CheR; CheR methyltransferase, SAM binding domain (PF01739; HMM-score: 30.8)
    CMAS; Mycolic acid cyclopropane synthetase (PF02353; HMM-score: 30.3)
    PrmA; Ribosomal protein L11 methyltransferase (PrmA) (PF06325; HMM-score: 27.5)
    MTS; Methyltransferase small domain (PF05175; HMM-score: 27.4)
    RrnaAD; Ribosomal RNA adenine dimethylase (PF00398; HMM-score: 22.1)
    Methyltransf_32; Methyltransferase domain (PF13679; HMM-score: 20.6)
    Methyltr_RsmB-F; 16S rRNA methyltransferase RsmB/F (PF01189; HMM-score: 19.1)
    TehB; Tellurite resistance protein TehB (PF03848; HMM-score: 18.7)
    DOT1; Histone methylation protein DOT1 (PF08123; HMM-score: 18)
    Methyltransf_4; Putative methyltransferase (PF02390; HMM-score: 17.1)
    MetW; Methionine biosynthesis protein MetW (PF07021; HMM-score: 17.1)
    Fibrillarin; Fibrillarin (PF01269; HMM-score: 16)
    TRM5-TYW2_MTfase; TRM5/TYW2 methyltransferase domain (PF02475; HMM-score: 16)
    Methyltransf_18; Methyltransferase domain (PF12847; HMM-score: 15.4)
    DREV; DREV methyltransferase (PF05219; HMM-score: 15.3)
    Methyltransf_24; Methyltransferase domain (PF13578; HMM-score: 13.6)
    UPF0020; RMKL-like, methyltransferase domain (PF01170; HMM-score: 13.5)
    no clan defined DUF7769; Domain of unknown function (DUF7769) (PF24964; HMM-score: 12.1)
    NADP_Rossmann (CL0063) GCD14; tRNA methyltransferase complex GCD14 subunit (PF08704; HMM-score: 11.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9622
    • Cytoplasmic Membrane Score: 0.0186
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.019
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011608
    • TAT(Tat/SPI): 0.002309
    • LIPO(Sec/SPII): 0.00478
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFMQNRNDFIEKLLDRAQIEEGMRVLDIGCATGEVTQLIAKRVGTNGEVVGVDVNESLLKIANENNQYNNVSYQSSDIYQLPETMGHFDAIVGRRVLMYLPDAEKCLQILKSILKPEGILCFQESDAINAGVGADTLSLHQSAIQWIWETVKQEGGNIHIGQNLYNLFNNNGMHVVDYFAEVVIQTSMDNDLAWLVDVMLQRMKAHGVINDDFSLDEFKSNLEQEAINNQCAFIRDMAFGIIGKA

⊟Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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