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NCBI: 10-JUN-2013

Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1809 [new locus tag: SACOL_RS09270 ]
  • pan locus tag?: SAUPAN004444000
  • symbol: SACOL1809
  • pan gene symbol?:
  • synonym:
  • product: drug transporter

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SACOL1809 [new locus tag: SACOL_RS09270 ]
  • symbol: SACOL1809
  • product: drug transporter
  • replicon: chromosome
  • strand: -
  • coordinates: 1865521..1866702
  • length: 1182
  • essential: unknown other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGAATATACCTAAATCAGTCTGGTGGCTAGTAATTGGCATGGCGTTAAATATTACTGGT
    TCCAGTTTTTTGTGGCCTTTAAATACAATTTATATGAAACAAGAACTTGGAAAAAGTTTA
    ACTGTTGCTGGTTTAGTGCTAATGATAAATTCATTTGGCATGGTTATTGGAAACTTATTA
    GGTGGTTCACTATTTGATAAATTAGGTGGATACAAGACGATTTTAATTGGAACTTTCACT
    TGTCTTTGTAGTACAACGCTACTTAATTTCTTTCACGGGTGGCCTTGGTATGCTGTATGG
    CTTGTAATGTTAGGGTTTGGTGGCGGAATGATTATTCCTGCGATATACGCTATGGCTGGA
    GCAGTGTGGCCAAATGGCGGAAGACAAACGTTTAATGCGATATACTTAGCGCAAAATATT
    GGTGTGGCTGTCGGTGCTGCAATGGGCGGCTTTGTCGCAGAATTTAGCTTTAACTATATC
    TTTTTAGCCAATCTTATTATGTATGTTGTGTTTGCGCTTGTCGCGGTAACGCAATTTAAT
    ATTGAAATTAATGCGAAAGTTAAATATCCAACTCATTTAGATATTACTGGTAAAAAGAAT
    AAAGCAAGATTTATTTCATTAGTACTAATTTGTGCAATGTTTGCAATTTGTTGGGTTGCA
    TATATTCAATGGGAGTCTACAATCGCTTCATTTACACAATCTATTAATATTTCAATGGCA
    CAATATAGTGTTTTATGGACAATTAACGGAATAATGATTTTAGTAGCACAACCATTAATT
    AAACCGATTCTCTATCTGTTAAAAGGAAACTTAAAGAAGCAAATGTTTGTCGGCATCATC
    ATTTTTATGTTGTCGTTCTTTGTCACGAGTTTTGCCGAAAACTTTACAATATTTGTTGTC
    GGTATGATTATTTTAACTTTTGGAGAAATGTTTGTATGGCCAGCAGTTCCAACTATAGCC
    AATCAGTTAGCGCCAGATGGTAAGCAAGGACAGTACCAAGGTTTTGTGAATTCAGCTGCT
    ACAGTAGGAAAAGCATTTGGTCCATTTCTTGGTGGTGTATTAGTTGATGCGTTTAATATG
    CGCATGATGTTTATCGGTATGATGCTACTACTTGTATTTGCATTAATATTATTAATGGTT
    TTCAAGGAGAATAATACGCAACCTAAAAAAATAGATGCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1182

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SACOL1809 [new locus tag: SACOL_RS09270 ]
  • symbol: SACOL1809
  • description: drug transporter
  • length: 393
  • theoretical pI: 9.75148
  • theoretical MW: 43344.8
  • GRAVY: 0.840204

Function[edit | edit source]

  • TIGRFAM:
    multidrug resistance protein (TIGR00880; HMM-score: 72.2)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-galactonate transporter (TIGR00893; HMM-score: 69.8)
    and 8 more
    Cellular processes Cellular processes Toxin production and resistance drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family (TIGR00711; HMM-score: 48.1)
    Metabolism Transport and binding proteins Other drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family (TIGR00711; HMM-score: 48.1)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids phosphoglycerate transporter family protein (TIGR00881; HMM-score: 31)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids MFS transporter, aromatic acid:H+ symporter (AAHS) family (TIGR00895; HMM-score: 30.5)
    Metabolism Transport and binding proteins Cations and iron carrying compounds H+ Antiporter protein (TIGR00900; HMM-score: 27)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids MFS transporter, sialate:H+ symporter (SHS) family (TIGR00891; HMM-score: 26.8)
    drug resistance transporter, Bcr/CflA subfamily (TIGR00710; HMM-score: 21.8)
    synaptic vesicle protein SV2 (TIGR01299; HMM-score: 4.3)
  • TheSEED  :
    • Multidrug resistance protein
  • PFAM:
    MFS (CL0015) MFS_1; Major Facilitator Superfamily (PF07690; HMM-score: 141.1)
    and 3 more
    MFS_1_like; MFS_1 like family (PF12832; HMM-score: 39.8)
    Sugar_tr; Sugar (and other) transporter (PF00083; HMM-score: 12.8)
    no clan defined Trp_oprn_chp; Tryptophan-associated transmembrane protein (Trp_oprn_chp) (PF09534; HMM-score: 12.3)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 12
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.032864
    • TAT(Tat/SPI): 0.000526
    • LIPO(Sec/SPII): 0.058627
  • predicted transmembrane helices (TMHMM): 12

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MNIPKSVWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTFTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFVAEFSFNYIFLANLIMYVVFALVAVTQFNIEINAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIASFTQSINISMAQYSVLWTINGIMILVAQPLIKPILYLLKGNLKKQMFVGIIIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPDGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMLLLVFALILLMVFKENNTQPKKIDA

Experimental data[edit | edit source]

  • experimentally validated: PeptideAtlas
  • protein localization: Integral membrane [1] [2]
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

  1. Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
    A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
    PLoS One: 2009, 4(12);e8176
    [PubMed:19997597] [WorldCat.org] [DOI] (I e)
  2. Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
    The Staphylococcus aureus proteome.
    Int J Med Microbiol: 2014, 304(2);110-20
    [PubMed:24439828] [WorldCat.org] [DOI] (I p)

Relevant publications[edit | edit source]