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NCBI: 03-AUG-2016

Summary[edit | edit source]

  • organism: Staphylococcus aureus NCTC8325
  • locus tag: SAOUHSC_01001
  • pan locus tag?: SAUPAN003269000
  • symbol: SAOUHSC_01001
  • pan gene symbol?: qoxB
  • synonym:
  • product: quinol oxidase subunit I

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SAOUHSC_01001
  • symbol: SAOUHSC_01001
  • product: quinol oxidase subunit I
  • replicon: chromosome
  • strand: -
  • coordinates: 973478..975466
  • length: 1989
  • essential: no DEG other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    ATGAATTTTCCATGGGATCAATTACTAGTTAAAGGTAACTGGATGATTACAATGGCACAA
    ATTGGTGCCCCATTCTTAGTTATTGGTTTAATCGCAGTAATTACTTACTTTAAATTATGG
    AAATATCTTTACAAAGAATGGTTCACATCTGTAGACCATAAGAAAATCGGTATTATGTAT
    TTAATCTGTGCCGTATTAATGTTCGTCCGTGGTGGTATTGATGCGTTACTTATTCGTGCG
    CAATTAACAGTACCTGATAACAAATTTTTAGAATCTAACCACTATAACGAAATTTTTAGT
    ACACATGGTGTAATCATGATTATCTTCATGGCAATGCCATTTATCTTTGGTTTATGGAAT
    ATCGTTGTTCCATTACAAATTGGAGCACGTGATGTTGCATTCCCAGTATTAAACAACGTA
    AGTTTCTGGCTATTCTTTGCAGGTATGATTTTATTCAACCTGTCATTTATTATTGGTGGT
    TCACCAGCAGCTGGTTGGACAAACTATGCGCCACTAGCAGGTGAATTCAGTCCTGGTCCG
    GGTGTTAACTATTACTTAATAGCTATACAAATTTCAGGGCTTGGTACCTTAGCTACAGGT
    ATCAACTTCTTTGTAACAATTTTAAGATGTAAAACACCAACTATGAAGTTTATGCAAATG
    CCAATGTTTACAGTAACAACATTTATTACTACATTAATTGTTATTCTTGCTTTCCCTCCT
    TTAACAGTAGCGTTAGCATTAATGACAACTGATAGAATATTTGACACAGCATTCTTCACA
    GTTGCACATGGCGGTATGCCAATGCTTTGGGCTAACTTCTTCTGGGTATGGGGGCACCCT
    GAAGTTTATATCGTTATCCTTCCAGCATTTGGTATTTACTCAGAAATTATCCCGACATTC
    GCTCGTAAGCGTTTATTCGGACATCAAAGTATGGTATGGGCAACTGCCGGTATCGCGTTC
    CTTAGTTTCTTAGTTTGGGTTCACCATTTCTTCACAATGGGTAATGGTGCGTTAATCAAC
    TCATTCTTCTCAATTTCAACAATGCTGATTGGTATTCCAACTGGTGTGAAATTGTTTAAC
    TGGTTATTAACATTATATAAAGGACGTATTACATTTGAGTCACCAATGCTATTCTCATTA
    GCATTTATCCCTAACTTCCTTTTAGGTGGTGTTACGGGTGTAATGTTAGCAATGGCATCA
    GCTGACTATCAATATCACAATACGTACTTCTTAGTAGCTCACTTCCACTATACATTGGTT
    ACTGGTGTTGTATTTGCCTGCTTAGCTGGTTTAATCTTCTGGTATCCAAAGATGATGGGT
    TACAAATTAAACGAAACATTAAACAAATGGTGCTTCTGGTTCTTCATGATCGGATTTAAC
    GTTTGTTTCTTACCACAATTCATTCTTGGATTAGATGGTATGCCACGTCGTTTATACACT
    TATATGCCATCAGATGGTTGGTTCTTATTAAACTTAATTTCAACTATCGGTGCATTATTA
    ATGGCAATCGGATTCTTATTCCTTGTTGTTAGTATCGTATACAGTCACTTCAAATCTCCA
    CGTGAAGCAACTGGAGATAACTGGGATGGCCTTGGTCGTACTCTAGAGTGGACTACTGCA
    TCAGCAATTCCACCTAAATACAACTTTGCCATTACACCAGATTGGAATGACTACGACACA
    TTTGTTGATATGAAAGAACATGGTCGTCATTACTTAGACAACCATAATTACAAAGACATT
    CATATGCCAAACAATACTCCTGTTGGATTCTGGATTGGTATCTTTATGACTATCGGCGGT
    TTCTTCTTAATTTTCGAAACTGTAATTCCAGCATTAATTTGTTTATTCGGTATTTTTGGT
    ACTATGATTTATCGCAGTTTCCAAATCGATCACGGATATCATATCCCTGCTGCTGAAGTT
    GCAGAAACTGAAGCTAGATTAAGAGAAGCGCGTATTAAAGAAAGGGAGGCTGTAAGTCAT
    GAGTCATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    1989

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SAOUHSC_01001
  • symbol: SAOUHSC_01001
  • description: quinol oxidase subunit I
  • length: 662
  • theoretical pI: 7.7182
  • theoretical MW: 75242.4
  • GRAVY: 0.585499

Function[edit | edit source]

  • reaction:
    EC 1.9.3.-?  ExPASy
    EC 1.10.3.-?  ExPASy
    2 a quinol + O2 = 2 a quinone + 2 H2O?
  • TIGRFAM:
    Metabolism Energy metabolism Electron transport cytochrome aa3 quinol oxidase, subunit I (TIGR02882; EC 1.10.3.-; HMM-score: 1267.6)
    and 3 more
    Metabolism Energy metabolism Electron transport cytochrome o ubiquinol oxidase, subunit I (TIGR02843; EC 1.10.3.-; HMM-score: 795.8)
    Metabolism Energy metabolism Electron transport cytochrome c oxidase, subunit I (TIGR02891; EC 1.9.3.1; HMM-score: 624.9)
    glycosyltransferase, TIGR04182 family (TIGR04182; HMM-score: 10)
  • TheSEED  :
    • AA3-600 quinol oxidase subunit I
    Respiration Electron accepting reactions Terminal cytochrome C oxidases  quinol oxidase polypeptide I QoxB (EC:1.9.3.-)
  • PFAM:
    no clan defined COX1; Cytochrome C and Quinol oxidase polypeptide I (PF00115; HMM-score: 464)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors: Cu cation, ferriheme a
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 14
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.000531
    • TAT(Tat/SPI): 0.000191
    • LIPO(Sec/SPII): 0.022872
  • predicted transmembrane helices (TMHMM): 15

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MNFPWDQLLVKGNWMITMAQIGAPFLVIGLIAVITYFKLWKYLYKEWFTSVDHKKIGIMYLICAVLMFVRGGIDALLIRAQLTVPDNKFLESNHYNEIFSTHGVIMIIFMAMPFIFGLWNIVVPLQIGARDVAFPVLNNVSFWLFFAGMILFNLSFIIGGSPAAGWTNYAPLAGEFSPGPGVNYYLIAIQISGLGTLATGINFFVTILRCKTPTMKFMQMPMFTVTTFITTLIVILAFPPLTVALALMTTDRIFDTAFFTVAHGGMPMLWANFFWVWGHPEVYIVILPAFGIYSEIIPTFARKRLFGHQSMVWATAGIAFLSFLVWVHHFFTMGNGALINSFFSISTMLIGIPTGVKLFNWLLTLYKGRITFESPMLFSLAFIPNFLLGGVTGVMLAMASADYQYHNTYFLVAHFHYTLVTGVVFACLAGLIFWYPKMMGYKLNETLNKWCFWFFMIGFNVCFLPQFILGLDGMPRRLYTYMPSDGWFLLNLISTIGALLMAIGFLFLVVSIVYSHFKSPREATGDNWDGLGRTLEWTTASAIPPKYNFAITPDWNDYDTFVDMKEHGRHYLDNHNYKDIHMPNNTPVGFWIGIFMTIGGFFLIFETVIPALICLFGIFGTMIYRSFQIDHGYHIPAAEVAETEARLREARIKEREAVSHES

Experimental data[edit | edit source]

  • experimentally validated: PeptideAtlas [1] [2]
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

  1. Maren Depke, Stephan Michalik, Alexander Rabe, Kristin Surmann, Lars Brinkmann, Nico Jehmlich, Jörg Bernhardt, Michael Hecker, Bernd Wollscheid, Zhi Sun, Robert L Moritz, Uwe Völker, Frank Schmidt
    A peptide resource for the analysis of Staphylococcus aureus in host-pathogen interaction studies.
    Proteomics: 2015, 15(21);3648-61
    [PubMed:26224020] [WorldCat.org] [DOI] (I p)
  2. Stephan Michalik, Maren Depke, Annette Murr, Manuela Gesell Salazar, Ulrike Kusebauch, Zhi Sun, Tanja C Meyer, Kristin Surmann, Henrike Pförtner, Petra Hildebrandt, Stefan Weiss, Laura Marcela Palma Medina, Melanie Gutjahr, Elke Hammer, Dörte Becher, Thomas Pribyl, Sven Hammerschmidt, Eric W Deutsch, Samuel L Bader, Michael Hecker, Robert L Moritz, Ulrike Mäder, Uwe Völker, Frank Schmidt
    A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions.
    Sci Rep: 2017, 7(1);9718
    [PubMed:28887440] [WorldCat.org] [DOI] (I e)
  3. 3.0 3.1 Ulrike Mäder, Pierre Nicolas, Maren Depke, Jan Pané-Farré, Michel Debarbouille, Magdalena M van der Kooi-Pol, Cyprien Guérin, Sandra Dérozier, Aurelia Hiron, Hanne Jarmer, Aurélie Leduc, Stephan Michalik, Ewoud Reilman, Marc Schaffer, Frank Schmidt, Philippe Bessières, Philippe Noirot, Michael Hecker, Tarek Msadek, Uwe Völker, Jan Maarten van Dijl
    Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions.
    PLoS Genet: 2016, 12(4);e1005962
    [PubMed:27035918] [WorldCat.org] [DOI] (I e)

Relevant publications[edit | edit source]