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NCBI: 10-JUN-2013

Summary[edit | edit source]

  • organism: Staphylococcus aureus USA300_FPR3757
  • locus tag: SAUSA300_1232 [new locus tag: SAUSA300_RS06680 ]
  • pan locus tag?: SAUPAN003707000
  • symbol: SAUSA300_1232
  • pan gene symbol?: katA
  • synonym:
  • product: catalase

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SAUSA300_1232 [new locus tag: SAUSA300_RS06680 ]
  • symbol: SAUSA300_1232
  • product: catalase
  • replicon: chromosome
  • strand: +
  • coordinates: 1349997..1351514
  • length: 1518
  • essential: unknown other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGTCACAACAAGACAAAAAGTTAACTGGTGTTTTTGGGCATCCAGTATCAGACCGAGAA
    AATAGTATGACAGCAGGGCCTAGGGGACCTCTTTTAATGCAAGATATTTACTTTTTAGAG
    CAAATGTCTCAATTTGATAGAGAAGTAATACCAGAACGTCGAATGCATGCCAAAGGTTCT
    GGTGCATTTGGGACATTTACTGTAACTAAAGATATAACAAAATATACGAATGCTAAAATA
    TTCTCTGAAATAGGTAAGCAAACCGAAATGTTTGCCCGTTTCTCTACTGTAGCAGGAGAA
    CGTGGTGCTGCTGATGCGGAGCGTGACATTCGAGGATTTGCGTTAAAGTTCTACACTGAA
    GAAGGGAACTGGGATTTAGTAGGGAATAACACACCAGTATTCTTCTTTAGAGATCCAAAG
    TTATTTGTTAGTTTAAATCGTGCGGTGAAACGAGATCCTAGAACAAATATGAGAGATGCA
    CAAAATAACTGGGATTTCTGGACGGGTCTTCCAGAAGCATTGCACCAAGTAACGATCTTA
    ATGTCAGATAGAGGGATTCCTAAAGATTTACGTCATATGCATGGGTTCGGTTCTCACACA
    TACTCTATGTATAATGATTCTGGTGAACGTGTTTGGGTTAAATTCCATTTTAGAACGCAA
    CAAGGTATTGAAAACTTAACTGATGAAGAAGCTGCTGAAATTATAGCTACAGATCGTGAT
    TCATCTCAACGCGATTTATTCGAAGCCATTGAAAAAGGTGATTATCCAAAATGGACAATG
    TATATTCAAGTAATGACTGAGGAACAAGCTAAAAACCATAAAGATAATCCATTTGATTTA
    ACAAAAGTATGGTATCACGATGAGTATCCTCTAATTGAAGTTGGAGAGTTTGAATTAAAT
    AGAAATCCAGATAATTACTTTATGGATGTTGAACAAGCTGCGTTTGCACCAACTAATATT
    ATTCCAGGATTAGATTTTTCTCCAGACAAAATGCTGCAAGGGCGTTTATTCTCATATGGC
    GATGCGCAAAGATATCGATTAGGAGTTAATCATTGGCAGATTCCTGTAAACCAACCTAAA
    GGTGTTGGTATTGAAAATATTTGTCCTTTTAGTAGAGATGGTCAAATGCGCGTAGTTGAC
    AATAACCAAGGTGGAGGAACACATTATTATCCAAATAACCATGGTAAATTTGATTCTCAA
    CCTGAATATAAAAAGCCACCATTCCCAACTGATGGATACGGCTATGAATATAATCAACGT
    CAAGATGATGATAATTATTTTGAACAACCAGGTAAATTGTTTAGATTACAATCAGAGGAC
    GCTAAAGAAAGAATTTTTACAAATACAGCAAATGCAATGGAAGGCGTAACGGATGATGTT
    AAACGACGTCATATTCGTCATTGTTACAAAGCTGACCCAGAATATGGTAAAGGTGTTGCA
    AAAGCATTAGGTATTGATATAAATTCTATTGATCTTGAAACTGAAAATGATGAAACATAC
    GAAAACTTTGAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1518

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SAUSA300_1232 [new locus tag: SAUSA300_RS06680 ]
  • symbol: SAUSA300_1232
  • description: catalase
  • length: 505
  • theoretical pI: 5.13252
  • theoretical MW: 58379.5
  • GRAVY: -0.845743

Function[edit | edit source]

  • reaction:
    EC 1.11.1.6?  ExPASy
    Catalase 2 H2O2 = O2 + 2 H2O
  • TIGRFAM:
  • TheSEED  :
    • Catalase KatE (EC 1.11.1.6)
    Stress Response Oxidative stress Oxidative stress  Catalase (EC 1.11.1.6)
    and 1 more
    Stress Response Oxidative stress Protection from Reactive Oxygen Species  Catalase (EC 1.11.1.6)
  • PFAM:
    no clan defined Catalase; Catalase (PF00199; HMM-score: 607)
    and 1 more
    Catalase-rel; Catalase-related immune-responsive (PF06628; HMM-score: 80.3)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors: heme
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.035586
    • TAT(Tat/SPI): 0.006403
    • LIPO(Sec/SPII): 0.001321
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MSQQDKKLTGVFGHPVSDRENSMTAGPRGPLLMQDIYFLEQMSQFDREVIPERRMHAKGSGAFGTFTVTKDITKYTNAKIFSEIGKQTEMFARFSTVAGERGAADAERDIRGFALKFYTEEGNWDLVGNNTPVFFFRDPKLFVSLNRAVKRDPRTNMRDAQNNWDFWTGLPEALHQVTILMSDRGIPKDLRHMHGFGSHTYSMYNDSGERVWVKFHFRTQQGIENLTDEEAAEIIATDRDSSQRDLFEAIEKGDYPKWTMYIQVMTEEQAKNHKDNPFDLTKVWYHDEYPLIEVGEFELNRNPDNYFMDVEQAAFAPTNIIPGLDFSPDKMLQGRLFSYGDAQRYRLGVNHWQIPVNQPKGVGIENICPFSRDGQMRVVDNNQGGGTHYYPNNHGKFDSQPEYKKPPFPTDGYGYEYNQRQDDDNYFEQPGKLFRLQSEDAKERIFTNTANAMEGVTDDVKRRHIRHCYKADPEYGKGVAKALGIDINSIDLETENDETYENFEK

Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulators: PerR* (repression) regulon, CodY (repression) regulon
    PerR*(TF)important in Oxidative stress response; RegPrecise 
    CodY(TF)important in Amino acid metabolism; RegPrecise 

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]