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NCBI: 22-FEB-2026

⊟Summary[edit | edit source]

organism: Staphylococcus aureus JSNZ
locus tag: EGJ38_RS06885 [old locus tag: EGJ38_001379 ]
pan locus tag^?: SAUPAN003808000
symbol: dapA
pan gene symbol^?: dapA
synonym:
product: 4-hydroxy-tetrahydrodipicolinate synthase

⊟Additional information (user-provided)[edit | edit source]

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

type: CDS
locus tag: EGJ38_RS06885 [old locus tag: EGJ38_001379 ]
symbol: dapA
product: 4-hydroxy-tetrahydrodipicolinate synthase
replicon: chromosome
strand: +
coordinates: 1394892..1395779
length: 888
essential: unknown other strains

⊟Accession numbers[edit | edit source]

Location: NZ_CM129921 (1394892..1395779) NCBI
BioCyc:
MicrobesOnline:

⊟Phenotype[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟DNA sequence[edit | edit source]

1
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121
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841
ATGACACATTTATTTGAGGGTGTTGGCGTTGCACTTACAACCCCTTTTACAAATAACAAA
GTTAATCTTGAAGCTTTGAAAGCACACGTTAATTTTTTACTAGAAAATAATACCCAAGCA
ATCATCGTTAATGGAACTACTGCTGAGAGCCCTACTTTAACAACAGATGAAAAAGAACTT
ATTCTAAAAACAGTTATTGATCTTGTAGATAAACGTGTTCCTGTCATAGCTGGAACTGGA
ACTAATGATACTGAAAAGTCAATCCAAGCTTCATTCCAAGCTAAAGCCTTAGGGGCTGAT
GCAATTATGTTAATTACGCCCTACTACAACAAAACGAATCAACGTGGTTTAGTCAAACAC
TTTGAAGCGATTGCAGATGCTGTGAAATTACCAGTCGTGCTGTACAATGTTCCTTCAAGA
ACGAACATGACAATTGAACCAGAAACTGTAGAAATATTAAGTCAACATCCTTATATAGTT
GCTTTAAAAGATGCTACGAATGATTTTGAGTATTTAGAAGAAGTGAAAAAGCGAATTGAT
ACAAATTCATTTGCATTATATAGTGGCAATGATGACAACGTCGTCGAATACTATCAACGT
GGCGGTCAAGGGGTTATCTCTGTTATTGCCAATGTCATTCCTAAAGAATTTCAAGCGTTA
TACGATGCTCAACAAAGTGGATTAGATATTCAAGATCAATTTAAACCAATCGGCACACTG
TTATCAGCCCTATCAGTTGATATTAACCCAATTCCTATTAAAGCTTTAACAAGTTATTTA
GAATTTGGAAACTATGAATTACGTTTACCATTGGTTAGCCTAGAAGATACAGATACTAAA
GTGCTTCGTGAAGCATATGACACATTTAAAGCGGGTGAAAATGAGTGA
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888

⊟Protein[edit | edit source]

⊟General[edit | edit source]

locus tag: EGJ38_RS06885 [old locus tag: EGJ38_001379 ]
symbol: DapA
description: 4-hydroxy-tetrahydrodipicolinate synthase
length: 295
theoretical pI: 4.44117
theoretical MW: 32616.7
GRAVY: -0.137288

⊟Function[edit | edit source]

reaction:
EC 4.3.3.7? ExPASy
4-hydroxy-tetrahydrodipicolinate synthase Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + H₂O
TIGRFAM:
Metabolism Amino acid biosynthesis Aspartate family 4-hydroxy-tetrahydrodipicolinate synthase (TIGR00674; EC 4.3.3.7; HMM-score: 277.4)
and 5 more
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase (TIGR02313; EC 4.1.2.-; HMM-score: 186.3)
5-dehydro-4-deoxyglucarate dehydratase (TIGR03249; EC 4.2.1.41; HMM-score: 106.3)
Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides N-acetylneuraminate lyase (TIGR00683; EC 4.1.3.3; HMM-score: 94.8)
Metabolism Central intermediary metabolism Amino sugars N-acetylneuraminate lyase (TIGR00683; EC 4.1.3.3; HMM-score: 94.8)
Unknown function General IMP dehydrogenase family protein (TIGR01304; HMM-score: 13.4)
TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
PFAM:
TIM_barrel (CL0036) DHDPS; Dihydrodipicolinate synthetase family (PF00701; HMM-score: 247.4)
and 3 more
SIS (CL0067) SIS; SIS domain (PF01380; HMM-score: 12.7)
Flavoprotein (CL0042) FMN_red; NADPH-dependent FMN reductase (PF03358; HMM-score: 12.3)
TIM_barrel (CL0036) NMO; Nitronate monooxygenase (PF03060; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

domains:
modifications:
cofactors:
effectors:

⊟Localization[edit | edit source]

PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9958
- Cytoplasmic Membrane Score: 0.0011
- Cell wall & surface Score: 0.0003
- Extracellular Score: 0.0028
LocateP:
SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.00804
- TAT(Tat/SPI): 0.00052
- LIPO(Sec/SPII): 0.000534
predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

GI:
RefSeq: WP_000149281 NCBI
UniProt:

⊟Additional information (user-provided)[edit | edit source]

⊟Protein sequence[edit | edit source]

MTHLFEGVGVALTTPFTNNKVNLEALKAHVNFLLENNTQAIIVNGTTAESPTLTTDEKELILKTVIDLVDKRVPVIAGTGTNDTEKSIQASFQAKALGADAIMLITPYYNKTNQRGLVKHFEAIADAVKLPVVLYNVPSRTNMTIEPETVEILSQHPYIVALKDATNDFEYLEEVKKRIDTNSFALYSGNDDNVVEYYQRGGQGVISVIANVIPKEFQALYDAQQSGLDIQDQFKPIGTLLSALSVDINPIPIKALTSYLEFGNYELRLPLVSLEDTDTKVLREAYDTFKAGENE

⊟Experimental data[edit | edit source]

experimentally validated: data available for COL, NCTC8325
protein localization: data available for COL
quantitative data / protein copy number per cell: data available for COL
interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

regulator: CodY see EGJ38_001379

⊟Additional information (user-provided)[edit | edit source]

⊟Transcription pattern[edit | edit source]

S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

Aureolib: data available for COL

⊟Protein stability[edit | edit source]

half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟Other information (user-provided)[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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