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PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_001980
  • pan locus tag?: SAUPAN005201000
  • symbol: hemA
  • pan gene symbol?: hemA
  • synonym:
  • product: 5-aminolevulinate synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_001980
  • symbol: hemA
  • product: 5-aminolevulinate synthase
  • replicon: chromosome
  • strand: -
  • coordinates: 1993664..1994806
  • length: 1143
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATATTTACTGAGATTAACAGGATTGCAAACAAATATCCATTAGCCAAAGGGGAAGATGGT
    AAAGAGGTTGTTGTGTTTTGTAGTAACGATTATTTAGGTATGTCTCAAAATCAAGAAGTA
    ATAAATGTAATGAGTGATGCTTTAAAAGAATATGGTGCAGGGGCAGGTGGTTCAAGGAAT
    ATTGGTGGAAGCCATAAATATTTTAAACTATTAGAAAATGAGATAGCAAAATGGCATAAA
    AAGGACTCAGCTTTAGTTTTTCCAACAGGATACTCTTCAAATGATGCGTCTTTGCAAGGT
    TTATTAAGAATATTCCCAGAAATGATTGTATTTTCTGATTCTAAAAATCATGCGTCTATA
    ATAAATGCTTTGCGAAGTGTTAAAAATAAGATTGAAATTTTTGAACATAATAATGTTAAA
    CATTTAAATGAATTACTGAATCAATATGATATTAATATACCAAAGTTAATAGTATTTGAG
    TCTGTATATTCAATGGATGGAGACATTGCACCAATAGTAGAGATAGTCGAATTAGCAAAA
    GAATATAATTCTTTAACTTTTTTAGATGAAGTACATGCAATTGGCATGTATGGTGAAGAA
    GGAAGAGGATACTCTGATGTTGTTGGTGTTCAGGAAGATATAGACATCATACAATCTACA
    ATGGCAAAAGGAATCGGAATAATAGGAGGATATATAACCGGAGATCAATTACTCATAGAT
    GTAATCAGATCATATTCTTCAGGTTTTATATTTACTACTGCATTACCTCCGGTTATTGCT
    GCGGGTTGTTTAACTAGTATAAAAATAGTCAGAAGTAATGATAAATTAAGAGAAGAATTG
    CAAGATAAAACGAAATACTTAAAAGAAAAATTCAAAGAAAATGGTATTGAAGTTTTGAAA
    CAAAGTAAGACACATATACTCCCAGTTATAATTGGAGATTCAAAAAAATGTGAGGAAGCA
    GCAAAGTTACTTCTAGATAAATTTAATATTTATGTTCAAGCAATTAATTCACCTACTGTA
    GAAATTGGTACTGAAAGATTTAGAATTAATGTAACGCCAAATCACACAAAAGAACAAATG
    GATTTATTGGTTTCTTCAATTGTTTATGTTTTTGATTTTTTGAACATTAGGAGAAGTGTG
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1143

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_001980
  • symbol: HemA
  • description: 5-aminolevulinate synthase
  • length: 380
  • theoretical pI: 5.68784
  • theoretical MW: 42500.5
  • GRAVY: -0.112895

⊟Function[edit | edit source]

  • reaction:
    EC 2.3.1.37?  ExPASy
    5-aminolevulinate synthase Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin 5-aminolevulinic acid synthase (TIGR01821; EC 2.3.1.37; HMM-score: 495.2)
    and 10 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin 8-amino-7-oxononanoate synthase (TIGR00858; EC 2.3.1.47; HMM-score: 335.2)
    putative pyridoxal phosphate-dependent acyltransferase (TIGR01825; EC 2.3.1.-; HMM-score: 307.8)
    Metabolism Energy metabolism Amino acids and amines glycine C-acetyltransferase (TIGR01822; EC 2.3.1.29; HMM-score: 253.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin glutamate-1-semialdehyde-2,1-aminomutase (TIGR00713; EC 5.4.3.8; HMM-score: 30.8)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 30.6)
    ornithine--oxo-acid transaminase (TIGR01885; EC 2.6.1.13; HMM-score: 22.4)
    succinyldiaminopimelate transaminase (TIGR03537; EC 2.6.1.17; HMM-score: 18.4)
    LL-diaminopimelate aminotransferase (TIGR03540; EC 2.6.1.83; HMM-score: 13.6)
    UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase (TIGR03588; EC 2.6.1.92; HMM-score: 12.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, SufS family (TIGR01979; HMM-score: 12.1)
  • TheSEED:
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 218.3)
    and 4 more
    Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 21.7)
    Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 18.6)
    NADP_Rossmann (CL0063) Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 14.7)
    PLP_aminotran (CL0061) Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 11.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9316
    • Cytoplasmic Membrane Score: 0.0093
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0589
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.015512
    • TAT(Tat/SPI): 0.000826
    • LIPO(Sec/SPII): 0.002689
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFTEINRIANKYPLAKGEDGKEVVVFCSNDYLGMSQNQEVINVMSDALKEYGAGAGGSRNIGGSHKYFKLLENEIAKWHKKDSALVFPTGYSSNDASLQGLLRIFPEMIVFSDSKNHASIINALRSVKNKIEIFEHNNVKHLNELLNQYDINIPKLIVFESVYSMDGDIAPIVEIVELAKEYNSLTFLDEVHAIGMYGEEGRGYSDVVGVQEDIDIIQSTMAKGIGIIGGYITGDQLLIDVIRSYSSGFIFTTALPPVIAAGCLTSIKIVRSNDKLREELQDKTKYLKEKFKENGIEVLKQSKTHILPVIIGDSKKCEEAAKLLLDKFNIYVQAINSPTVEIGTERFRINVTPNHTKEQMDLLVSSIVYVFDFLNIRRSV

⊟Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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