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NCBI: 06-JUL-2013

Summary[edit | edit source]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_1575 [new locus tag: NWMN_RS08835 ]
  • pan locus tag?: SAUPAN004301000
  • symbol: lysP
  • pan gene symbol?: lysP
  • synonym:
  • product: lysine-specific permease

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: NWMN_1575 [new locus tag: NWMN_RS08835 ]
  • symbol: lysP
  • product: lysine-specific permease
  • replicon: chromosome
  • strand: -
  • coordinates: 1740636..1742129
  • length: 1494
  • essential: unknown other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    ATGTCAAAAGTTCAAAATGAAAGTAACAATGTTGTCAAAAGGGGACTTAAAGATCGTCAT
    ATTTCTATGATTGCGATTGGGGGTTGTATTGGTACAGGTTTATTTGTAACTTCTGGTGGA
    GCAATTCATGATGCAGGTGCTTTGGGTGCATTAATAGGATACGCAATTATCGGAATAATG
    GTATTTTTCTTAATGACGTCACTTGGCGAAATGGCTACGTATTTGCCAGTATCAGGTTCA
    TTTAGTACATATGCTACAAGATTTGTTGATCCATCTTTAGGGTTTGCGCTTGGTTGGAAC
    TATTGGTTTAACTGGGTAGTGACTGTAGCAGCAGATATTACGATTGCAGCACAAGTCATT
    CAATATTGGACACCATTGCAAGGCATACCCGCTTGGGCATGGAGTGCGTTGTTCTTAGTT
    ATAATTTTTAGTCTGAATTCGTTATCAGTTCGCGTCTATGGTGAAAGTGAATACTGGTTG
    GCATTGATAAAAGTGGTTACAGTTATTGTTTTCATTGCAATTGGTTTATTAACGATTGTC
    GGAATCATGGGTGGTCATGTTGTAGGATTCGAAATATTTAATAAAGGTGAAGGTCCAATT
    CTTGGTGGCAACTTAGGAGGAAGTTTGTTATCAATTCTAGGTGTATTCTTAATCGCTGGT
    TTCTCATTCCAAGGTACTGAGTTAATTGGTATTACGGCTGGTGAATCAGAAAATCCTGAA
    CGTGCTGTGCCGAAAGCAATTAAACAAGTATTCTGGAGAATTTTATTATTTTACATTTTA
    GCCATTTTTGTTATCGGTATGTTAATTCCTTATGATAGTAGTGCATTAATGGGGGGTAGT
    GATAATGTAGCAACGTCTCCATTCACATTAGTGTTTAAAAATGCTGGATTTGCGTTTGCA
    GCATCATTTATGAATGCAGTCATTTTAACGTCTGTGTTATCAGCAGGTAACTCAGGTATG
    TATGCTTCAACTCGAATGCTATATTCAATGAGTAAAGATAAATTAGCGTTTGAAGCATTT
    GGTAAAACAAATAAAAACGGTGTGCCATATATGTCGTTACTCGTTACAGCAATCATTGTA
    GTGATAATTTTCGTATTACAAAGCCTTACAAAAGGTGCATACGAATATATCGTTGCAGCA
    AGTGGTTTAACTGGTTTTATTGCTTGGGTAGGTATAGCAGTAAGTCATTATCGATTTAGA
    AGAGCATTTGATAAACAAAATTATGACAAATCTAAATTAAAATATACTGCTAAATTATTC
    CCATTCGGACCATTATTTGCTGGCTTTTTATGTATTGTAGTAATTATTGGTCAAGATGTT
    GACTTTATTAAAACAGGAGATTTTAATTTTAGTCGCTTCTTAATTACGTATATGGGAATT
    CCAGTATTTTTAGCATTCTTTATTTATCATAAGCTTCGATATAAAACGAAAAAAATTCCA
    TTAGAACAAGTAGATTTACGTCAAGACGTGTCAATGGATGAAATAAAAGGTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1494

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: NWMN_1575 [new locus tag: NWMN_RS08835 ]
  • symbol: LysP
  • description: lysine-specific permease
  • length: 497
  • theoretical pI: 9.51176
  • theoretical MW: 54218.4
  • GRAVY: 0.655332

Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Amino acids, peptides and amines amino acid permease (yeast) (TIGR00913; HMM-score: 467.6)
    and 10 more
    Metabolism Transport and binding proteins Amino acids, peptides and amines GABA permease (TIGR01773; HMM-score: 308.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines amino acid transporter (TIGR00909; HMM-score: 97.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines transporter, basic amino acid/polyamine antiporter (APA) family (TIGR00905; HMM-score: 69.5)
    Metabolism Transport and binding proteins Amino acids, peptides and amines arginine-ornithine antiporter (TIGR03810; HMM-score: 56.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines ethanolamine permease (TIGR00908; HMM-score: 53.2)
    Metabolism Transport and binding proteins Amino acids, peptides and amines L-type amino acid transporter (TIGR00911; HMM-score: 53.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines cationic amino acid transport permease (TIGR00906; HMM-score: 51.4)
    histidine-histamine antiporter (TIGR04298; HMM-score: 26.1)
    putative glutamate/gamma-aminobutyrate antiporter (TIGR03813; HMM-score: 14.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion protein EssC (TIGR03928; HMM-score: 12)
  • TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
  • PFAM:
    APC (CL0062) AA_permease; Amino acid permease (PF00324; HMM-score: 446.1)
    and 1 more
    AA_permease_2; Amino acid permease (PF13520; HMM-score: 159.7)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 12
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: 0
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.016178
    • TAT(Tat/SPI): 0.001639
    • LIPO(Sec/SPII): 0.129025
  • predicted transmembrane helices (TMHMM): 12

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MSKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIMVFFLMTSLGEMATYLPVSGSFSTYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVIQYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWLALIKVVTVIVFIAIGLLTIVGIMGGHVVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPERAVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGSDNVATSPFTLVFKNAGFAFAASFMNAVILTSVLSAGNSGMYASTRMLYSMSKDKLAFEAFGKTNKNGVPYMSLLVTAIIVVIIFVLQSLTKGAYEYIVAASGLTGFIAWVGIAVSHYRFRRAFDKQNYDKSKLKYTAKLFPFGPLFAGFLCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIPLEQVDLRQDVSMDEIKG

Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulators: L-box (transcription termination) regulon, SigB (activation) regulon
    L-box(RNA)important in Lysine biosynthesis; regulatory site identified based on RegPrecise data for N315 RegPrecise 
    SigB(sigma factor)controlling a large regulon involved in stress/starvation response and adaptation [1] [2]   other strains

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

  1. Markus Bischoff, Paul Dunman, Jan Kormanec, Daphne Macapagal, Ellen Murphy, William Mounts, Brigitte Berger-Bächi, Steven Projan
    Microarray-based analysis of the Staphylococcus aureus sigmaB regulon.
    J Bacteriol: 2004, 186(13);4085-99
    [PubMed:15205410] [WorldCat.org] [DOI] (P p)
  2. Bettina Schulthess, Dominik A Bloes, Patrice François, Myriam Girard, Jacques Schrenzel, Markus Bischoff, Brigitte Berger-Bächi
    The σB-dependent yabJ-spoVG operon is involved in the regulation of extracellular nuclease, lipase, and protease expression in Staphylococcus aureus.
    J Bacteriol: 2011, 193(18);4954-62
    [PubMed:21725011] [WorldCat.org] [DOI] (I p)

Relevant publications[edit | edit source]