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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_RS08755 [old locus tag: NWMN_1561 ]
  • pan locus tag?: SAUPAN004282000
  • symbol: NWMN_RS08755
  • pan gene symbol?: hemL
  • synonym:
  • product: glutamate-1-semialdehyde 2,1-aminomutase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: NWMN_RS08755 [old locus tag: NWMN_1561 ]
  • symbol: NWMN_RS08755
  • product: glutamate-1-semialdehyde 2,1-aminomutase
  • replicon: chromosome
  • strand: -
  • coordinates: 1727560..1728846
  • length: 1287
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_009641 (1727560..1728846) NCBI
  • BioCyc:
  • MicrobesOnline: see NWMN_1561

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGAGATATACGAAATCAGAAGAAGCAATGAAGGTTGCTGAAACTTTAATGCCTGGTGGT
    GTAAATAGTCCAGTACGCGCATTTAAATCAGTAGATACACCAGCAATTTTTATGGATCAC
    GGTAAAGGTTCAAAAATTTATGATATCGATGGTAACGAGTATATCGACTATGTACTAAGT
    TGGGGACCACTTATTTTAGGACATAGAGACCCTCAAGTTATTAGTCATTTACATGAAGCA
    ATTGATAAAGGTACAAGTTTTGGTGCATCAACATTACTTGAAAATAAATTGGCGCAGCTC
    GTTATTGACCGAGTACCTTCAATAGAAAAAGTGCGTATGGTGTCATCTGGTACAGAAGCT
    ACATTGGATACTTTAAGATTAGCACGTGGTTATACTGGCAGAAATAAAATTGTGAAATTT
    GAAGGTTGCTATCATGGTCATAGTGATTCGTTATTAATCAAAGCTGGTTCTGGGGTGGCA
    ACATTAGGATTGCCGGATTCTCCTGGTGTGCCTGAAGGTATTGCTAAAAATACAATTACA
    GTTCCATACAATGATTTAGATGCACTTAAAATCGCTTTCGAAAAATTTGGAAACGATATT
    GCTGGTGTAATCGTAGAACCTGTTGCTGGTAATATGGGTGTCGTACCGCCGATTGAAGGT
    TTTTTACAGGGATTAAGAGATATTACGACTGAATACGGCGCATTGCTAATTTTCGATGAA
    GTAATGACTGGTTTCAGAGTCGGTTATCATTGTGCACAAGGTTACTTTGGTGTGACACCA
    GATTTAACTTGCTTAGGAAAAGTTATCGGTGGAGGACTACCTGTAGGTGCATTTGGTGGT
    AAAAAAGAAATCATGGATCATATAGCACCATTAGGAAATATTTATCAAGCGGGTACGTTA
    TCAGGAAATCCTCTTGCAATGACAAGTGGTTATGAAACGTTAAGCCAATTAACGCCAGAG
    ACATATGAGTATTTTAATATGTTAGGCGATATACTTGAAGACGGTTTAAAACGTGTATTT
    GCTAAACACAATGTACCAATAACTGTAAATAGAGCAGGTTCAATGATTGGTTATTTCTTA
    AATGAAGGACCTGTAACTAATTTTGAACAAGCGAATAAAAGTGATTTGAAATTATTTGCA
    GAAATGTATCGAGAAATGGCAAAAGAAGGTGTGTTTTTACCACCATCTCAATTTGAAGGT
    ACATTCTTATCTACGGCACACACGAAAGAAGATATTGAAAAAACGATTCAAGCATTTGAT
    ACGGCTTTAAGTCGTATTGTAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1287

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: NWMN_RS08755 [old locus tag: NWMN_1561 ]
  • symbol: NWMN_RS08755
  • description: glutamate-1-semialdehyde 2,1-aminomutase
  • length: 428
  • theoretical pI: 5.29503
  • theoretical MW: 46387.8
  • GRAVY: -0.0616822

⊟Function[edit | edit source]

  • reaction:
    EC 5.4.3.8?  ExPASy
    Glutamate-1-semialdehyde 2,1-aminomutase (S)-4-amino-5-oxopentanoate = 5-aminolevulinate
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin glutamate-1-semialdehyde-2,1-aminomutase (TIGR00713; EC 5.4.3.8; HMM-score: 624.6)
    and 10 more
    transaminase, acetylornithine/succinylornithine family (TIGR00707; HMM-score: 179)
    Metabolism Energy metabolism Amino acids and amines succinylornithine transaminase family (TIGR03246; EC 2.6.1.81; HMM-score: 143.1)
    ornithine--oxo-acid transaminase (TIGR01885; EC 2.6.1.13; HMM-score: 134.9)
    Metabolism Central intermediary metabolism Other 4-aminobutyrate transaminase (TIGR00700; EC 2.6.1.19; HMM-score: 132.6)
    Metabolism Central intermediary metabolism Other 2,4-diaminobutyrate 4-transaminase (TIGR00709; EC 2.6.1.-; HMM-score: 125.3)
    Metabolism Central intermediary metabolism Polyamine biosynthesis putrescine aminotransferase (TIGR03372; EC 2.6.1.82; HMM-score: 121.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin adenosylmethionine-8-amino-7-oxononanoate transaminase (TIGR00508; EC 2.6.1.62; HMM-score: 120.8)
    Cellular processes Cellular processes Adaptations to atypical conditions diaminobutyrate--2-oxoglutarate aminotransferase (TIGR02407; EC 2.6.1.76; HMM-score: 89.9)
    L-lysine 6-transaminase (TIGR03251; EC 2.6.1.36; HMM-score: 46.7)
    Metabolism Central intermediary metabolism Other 4-aminobutyrate aminotransferase (TIGR00699; EC 2.6.1.19; HMM-score: 29.1)
  • TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_3; Aminotransferase class-III (PF00202; HMM-score: 246.9)
    and 1 more
    Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 16.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors: pyridoxal 5'-phosphate
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.024734
    • TAT(Tat/SPI): 0.002182
    • LIPO(Sec/SPII): 0.001986
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLSWGPLILGHRDPQVISHLHEAIDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEATLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVATLGLPDSPGVPEGIAKNTITVPYNDLDALKIAFEKFGNDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDEVMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTLSGNPLAMTSGYETLSQLTPETYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFLNEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEGTFLSTAHTKEDIEKTIQAFDTALSRIVK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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