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NCBI: 02-MAR-2017
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus Newman
- locus tag: NWMN_RS12005 [old locus tag: NWMN_2072 ]
- pan locus tag?: SAUPAN005560000
- symbol: NWMN_RS12005
- pan gene symbol?: —
- synonym:
- product: uridylyltransferase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: NWMN_RS12005 [old locus tag: NWMN_2072 ]
- symbol: NWMN_RS12005
- product: uridylyltransferase
- replicon: chromosome
- strand: -
- coordinates: 2308316..2309503
- length: 1188
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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1141ATGCTAGATAAAAATCAATTAGCTAAATATAAACAAGATCATTTGTGTGAATATGAAAAA
ATAATGAGTAACAATGAAAAAGAAGCACTTGAAGAGAAGGTAGCGTCATTAGATTTAGAT
TTTATTGCCAAATTATATAACGATTTATACATCAATAAGAAAACAATAGATGATGTATCT
GCAGTTTCTGAAGTGAAATATGATATTAAATCACAAATGAGTGATGATGAGATTAAGCGT
TTAGAGGAACAAGGACTTCAAGCTATTAAAGAAGGACAATTTGCAGTACTTTTGATGGCA
GGTGGTCAAGGAACAAGACTTGGTTACAAGGGCCCTAAAGGTTCGTTTGAAATTGAAGGT
GTAAGTTTATTTGAACTTCAAGCTAACCAATTAAAAACATTGAATCATCAATCTGGACAT
ACGATTCAATGGTATATTATGACAAGTGATATCAATCATGAAGAAACTTTAGCTTATTTC
GAAGCACATAGTTATTTTGGATATGATCAAGAAGCAATCCATTTCTTTAAACAAGATAAT
ATTGTGGCGCTTAGTGAAGAAGGGAAGTTAATTTTAAATCAACAGGGTCGTATTATGGAA
ACGCCGAATGGTAATGGTGGCGTGTTTAAATCTTTAGACAAGGCAGGATACTTAGAAGAA
ATGTCTAATAATGGCGTTAAGTATATTTTCTTGAATAATATCGACAATGTTTTAGTAAGA
GTGTTGGATCCACTATTTGCAGGATTTACGGTAGAACATGATTACGATATTACTTCTAAA
ACGATTCAACCAAAACCAGGAGAAAGTGTTGGACGTTTAGTTAATGTCGATTGTAAAGAT
ACAGTACTGGAGTATTCAGAATTAGATCCAGAAGTTGCAAATCAATTTAACAATGCTAAT
ATCGGTATTCATGCATTTAAACTTGGTTTTATTTTAAACGCTGTAAATCGTGAGTTACCT
TATCATTTAGCTATTAAGAATTTGAAGCAATTAGATGAGAACTTTGGTGTTATTGAACAA
CCAACTTTAAAATTCGAATTGTTCTATTTTGACATATTTACTTATGGAACTAGTTTTGTC
ACGTTACAAGTTCCTAGAGAAGAAGAATTTTCACCTCTTAAAAATAAAGAAGGTAAAGAT
AGTGTTGCAACTGCAACAGAAGATTTACGTAGAATGGGTTTAATTTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: NWMN_RS12005 [old locus tag: NWMN_2072 ]
- symbol: NWMN_RS12005
- description: uridylyltransferase
- length: 395
- theoretical pI: 4.60106
- theoretical MW: 44893.4
- GRAVY: -0.391899
⊟Function[edit | edit source]
- TIGRFAM: Hypothetical proteins Conserved TIGR00454 family protein (TIGR00454; HMM-score: 17)and 2 moreBiosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdenum cofactor guanylyltransferase (TIGR02665; EC 2.7.7.77; HMM-score: 13)Biosynthesis of cofactors, prosthetic groups, and carriers Other 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (TIGR00453; EC 2.7.7.60; HMM-score: 11.2)
- TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
- PFAM: GT-A (CL0110) UDPGP; UTP--glucose-1-phosphate uridylyltransferase (PF01704; HMM-score: 141.1)and 1 moreNTP_transf_3; MobA-like NTP transferase domain (PF12804; HMM-score: 17.9)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- LocateP:
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.001485
- TAT(Tat/SPI): 0.000152
- LIPO(Sec/SPII): 0.000474
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MLDKNQLAKYKQDHLCEYEKIMSNNEKEALEEKVASLDLDFIAKLYNDLYINKKTIDDVSAVSEVKYDIKSQMSDDEIKRLEEQGLQAIKEGQFAVLLMAGGQGTRLGYKGPKGSFEIEGVSLFELQANQLKTLNHQSGHTIQWYIMTSDINHEETLAYFEAHSYFGYDQEAIHFFKQDNIVALSEEGKLILNQQGRIMETPNGNGGVFKSLDKAGYLEEMSNNGVKYIFLNNIDNVLVRVLDPLFAGFTVEHDYDITSKTIQPKPGESVGRLVNVDCKDTVLEYSELDPEVANQFNNANIGIHAFKLGFILNAVNRELPYHLAIKNLKQLDENFGVIEQPTLKFELFYFDIFTYGTSFVTLQVPREEEFSPLKNKEGKDSVATATEDLRRMGLI
⊟Experimental data[edit | edit source]
- experimentally validated: data available for COL, NCTC8325
- protein localization: data available for COL
- quantitative data / protein copy number per cell: data available for COL
- interaction partners:
NWMN_RS08905 isocitrate dehydrogenase (NADP(+)) [1] (data from MRSA252) NWMN_RS11910 hypothetical protein [1] (data from MRSA252) NWMN_RS11915 ABC transporter permease [1] (data from MRSA252)
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator: CcpA, LexA see NWMN_2072
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ 1.0 1.1 1.2 Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
J Proteome Res: 2011, 10(3);1139-50
[PubMed:21166474] [WorldCat.org] [DOI] (I p)