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NCBI: 26-AUG-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA0519 [new locus tag: SA_RS03025 ]
  • pan locus tag?: SAUPAN002335000
  • symbol: sdrC
  • pan gene symbol?: sdrC
  • synonym:
  • product: Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA0519 [new locus tag: SA_RS03025 ]
  • symbol: sdrC
  • product: Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein
  • replicon: chromosome
  • strand: +
  • coordinates: 605215..608076
  • length: 2862
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    ATGAATAATAAAAAGACAGCAACAAATAGAAAAGGCATGATACCAAATCGATTAAACAAA
    TTTTCGATAAGAAAGTATTCTGTAGGTACTGCTTCAATTTTAGTAGGGACAACATTGATT
    TTTGGGTTAAGTGGTCATGAAGCTAAAGCGGCAGAACATACGAATGGAGAATTAAATCAA
    TCAAAAAATGAAACGACAGCCCCAAGTGAGAATAAAACAACTGAAAAAGTTGATAGTCGT
    CAACTAAAAGACAATACGCAAACTGCAACTGCAGATCAGCCTAAAGTGACAATGAGTGAT
    AGTGCAACAGTTAAAGAAACTAGTAGTAACATGCAATCACCACAAAACGCTACAGCTAGT
    CAATCTACTACACAAACTAGCAATGTAACAACAAATGATAAATCATCAACTACATATAGT
    AATGAAACTGATAAAAGTAATTTAACACAAGCAAAAAACGTTTCAACTACACCTAAAACA
    ACGACTATTAAACAAAGAGCTTTAAATCGCATGGCAGTGAATACTGTTGCAGCTCCACAA
    CAAGGAACAAATGTTAATGATAAAGTACATTTTACGAACATTGATATTGCGATTGATAAA
    GGACATGTTAATAAAACAACAGGAAATACTGAATTTTGGGCAACTTCAAGTGATGTTTTA
    AAATTAAAAGCGAATTACACAATCGATGATTCTGTTAAAGAGGGCGATACATTTACTTTT
    AAATATGGTCAATATTTCCGTCCAGGTTCTGTAAGATTACCTTCACAAACTCAAAATTTA
    TATAATGCCCAAGGTAATATTATTGCAAAAGGTATTTACGATAGTAAAACAAATACAACA
    ACGTATACTTTTACGAATTATGTAGATCAATACACAAATGTTAGCGGTAGCTTTGAACAA
    GTCGCATTTGCGAAACGTGAAAATGCAACAACTGATAAAACTGCTTATAAAATGGAAGTA
    ACTTTAGGTAATGATACATATAGTAAAGATGTCATTGTCGATTATGGTAATCAAAAAGGT
    CAACAACTTATTTCGAGTACAAATTATATTAATAATGAAGATTTGTCACGTAATATGACT
    GTTTATGTAAATCAACCTAAAAAGACCTATACAAAAGAAACATTTGTAACAAATTTAACT
    GGTTATAAATTTAATCCAGATGCTAAAAACTTCAAAATTTACGAAGTGACAGATCAAAAT
    CAATTTGTGGATAGTTTCACCCCAGATACTTCAAAACTTAAAGATGTTACTGGTCAATTC
    GATGTTATTTATAGTAATGATAATAAGACGGCGACAGTAGATTTATTGAATGGTCAATCT
    AGTAGTGATAAACAGTACATCATTCAACAAGTTGCTTATCCAGATAATAGTTCAACAGAT
    AATGGGAAAATTGATTATACTTTAGAAACACAAAATGGAAAAAGTAGTTGGTCAAACAGT
    TATTCAAATGTGAATGGCTCATCAACTGCAAATGGCGACCAAAAGAAATATAATCTAGGT
    GACTATGTATGGGAAGATACAAATAAAGATGGTAAACAAGATGCCAATGAAAAAGGGATT
    AAAGGTGTTTATGTCATTCTTAAAGATAGTAACGGTAAAGAATTAGATCGTACGACAACA
    GATGAAAATGGTAAATATCAGTTCACTGGTTTAAGCAATGGAACTTATAGTGTAGAGTTT
    TCAACACCAGCCGGTTATACACCGACAACTGCAAATGCAGGTACAGATGATGCTGTAGAT
    TCTGATGGACTAACTACAACAGGTGTCATTAAAGACGCTGACAACATGACATTAGATAGT
    GGATTCTACAAAACACCAAAATATAGTTTAGGTGATTATGTTTGGTACGACAGTAATAAA
    GATGGTAAACAAGATTCGACTGAAAAAGGAATTAAAGGTGTTAAAGTTACTTTGCAAAAC
    GAAAAAGGCGAAGTAATTGGTACAACTGAAACAGATGAAAATGGTAAATACCGCTTTGAT
    AATTTAGATAGTGGTAAATACAAAGTTATCTTTGAAAAGCCTGCTGGTTTAACTCAAACA
    GGTACAAATACAACTGAAGATGATAAAGATGCCGATGGTGGCGAAGTTGATGTAACAATT
    ACGGATCATGATGATTTCACACTTGATAATGGCTACTACGAAGAAGAAACATCAGATAGT
    GACTCAGATTCGGACAGCGATTCAGACTCAGATAGCGACTCAGATTCAGATAGTGACTCA
    GACTCAGATAGCGACTCAGACTCAGATAGCGACTCAGACAGCGACTCAGACTCAGATAGT
    GATTCAGATTCGGACAGCGACTCAGATTCAGACAGCGAATCAGATTCGGATAGCGACTCA
    GACTCAGATAGCGACTCAGACAGCGACTCAGATTCAGACAGTGACTCAGACTCAGACAGC
    GACTCAGATTCAGACAGCGATTCAGATTCGGATAGCGACTCAGATTCAGATAGCGATTCG
    GACTCAGACAACGACTCAGATTCTGACAGCGATTCAGACTCAGATAGCGACTCAGATTCA
    GACAGCGACTCAGATTCAGACAGCGATTCAGATTCAGATAGCGATTCAGATTCAGACAGC
    GACTCAGATTCAGATAGCGACTCAGACTCAGACAGCGATTCAGACTCAGATAGCGACTCA
    GACAGCGATTCAGATTCGGATAGCGATTCAGATTCAGATGCAGGTAAACATACTCCGACT
    AAACCAATGAGTACGGTTAAAGATCAGCATAAAACAGCTAAAGCATTACCAGAAACAGGT
    AGTGAAAATAATAATTCAAATAATGGCACATTATTCGGTGGATTATTCGCGGCATTAGGA
    TCATTATTGTTATTCGGTCGTCGTAAAAAACAAAATAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2862

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA0519 [new locus tag: SA_RS03025 ]
  • symbol: SdrC
  • description: Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein
  • length: 953
  • theoretical pI: 3.95488
  • theoretical MW: 103292
  • GRAVY: -1.15582

⊟Function[edit | edit source]

  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 51.7)
    and 2 more
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 18.4)
    Metabolism Energy metabolism Other protocatechuate 3,4-dioxygenase, beta subunit (TIGR02422; EC 1.13.11.3; HMM-score: 15.4)
  • TheSEED  :
    • Adhesin of unknown specificity SdrC
    Virulence, Disease and Defense Adhesion Adhesins in Staphylococcus  Adhesin of unknown specificity SdrC
  • PFAM:
    Transthyretin (CL0287) SdrD_B; SdrD B-like domain (PF17210; HMM-score: 200.9)
    and 11 more
    Adhesin (CL0204) SdrG_C_C; C-terminus of bacterial fibrinogen-binding adhesin (PF10425; HMM-score: 97.9)
    Transthyretin (CL0287) CarboxypepD_reg; Carboxypeptidase regulatory-like domain (PF13620; HMM-score: 70.1)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 46.9)
    YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 45.6)
    E-set (CL0159) MG1; Alpha-2-macroglobulin MG1 domain (PF11974; HMM-score: 40.8)
    Transthyretin (CL0287) MetallophosN; N terminal of Calcineurin-like phosphoesterase (PF16371; HMM-score: 36.4)
    CarbopepD_reg_2; CarboxypepD_reg-like domain (PF13715; HMM-score: 35.9)
    DUF1416; Protein of unknown function (DUF1416) (PF07210; HMM-score: 17.6)
    DUF2606; Protein of unknown function (DUF2606) (PF10794; HMM-score: 17.3)
    Dioxygenase_C; Dioxygenase (PF00775; HMM-score: 14.6)
    GOLD-like (CL0521) EMP24_GP25L; emp24/gp25L/p24 family/GOLD (PF01105; HMM-score: 13.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • LocateP: LPxTG Cell-wall anchored
    • Prediction by SwissProt Classification: Cell Wall
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0
    • Signal peptide possibility: 1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: found LPxTG motif :LPETG
  • SignalP: Signal peptide SP(Sec/SPI) length 50 aa
    • SP(Sec/SPI): 0.875151
    • TAT(Tat/SPI): 0.090427
    • LIPO(Sec/SPII): 0.001955
    • Cleavage Site: CS pos: 50-51. AKA-AE. Pr: 0.9392
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNNKKTATNRKGMIPNRLNKFSIRKYSVGTASILVGTTLIFGLSGHEAKAAEHTNGELNQSKNETTAPSENKTTEKVDSRQLKDNTQTATADQPKVTMSDSATVKETSSNMQSPQNATASQSTTQTSNVTTNDKSSTTYSNETDKSNLTQAKNVSTTPKTTTIKQRALNRMAVNTVAAPQQGTNVNDKVHFTNIDIAIDKGHVNKTTGNTEFWATSSDVLKLKANYTIDDSVKEGDTFTFKYGQYFRPGSVRLPSQTQNLYNAQGNIIAKGIYDSKTNTTTYTFTNYVDQYTNVSGSFEQVAFAKRENATTDKTAYKMEVTLGNDTYSKDVIVDYGNQKGQQLISSTNYINNEDLSRNMTVYVNQPKKTYTKETFVTNLTGYKFNPDAKNFKIYEVTDQNQFVDSFTPDTSKLKDVTGQFDVIYSNDNKTATVDLLNGQSSSDKQYIIQQVAYPDNSSTDNGKIDYTLETQNGKSSWSNSYSNVNGSSTANGDQKKYNLGDYVWEDTNKDGKQDANEKGIKGVYVILKDSNGKELDRTTTDENGKYQFTGLSNGTYSVEFSTPAGYTPTTANAGTDDAVDSDGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKGVKVTLQNEKGEVIGTTETDENGKYRFDNLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDNDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPTKPMSTVKDQHKTAKALPETGSENNNSNNGTLFGGLFAALGSLLLFGRRKKQNK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

T J Foster, M Höök
Surface protein adhesins of Staphylococcus aureus.
Trends Microbiol: 1998, 6(12);484-8
[PubMed:10036727] [WorldCat.org] [DOI] (P p)

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