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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL0743 [new locus tag: SACOL_RS03815 ]
  • pan locus tag?: SAUPAN002567000
  • symbol: uppP
  • pan gene symbol?: uppP
  • synonym:
  • product: UDP pyrophosphate phosphatase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SACOL0743 [new locus tag: SACOL_RS03815 ]
  • symbol: uppP
  • product: UDP pyrophosphate phosphatase
  • replicon: chromosome
  • strand: -
  • coordinates: 763347..764222
  • length: 876
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGTTTATCATTGAATTAATAAAAGGTATTATCTTAGGGGTCGTCGAAGGATTAACAGAA
    TTTGCACCTGTTTCCTCTACTGGACATATGATCCTAGTTGATGATATGTGGTTAAAATCA
    TCTGAATTTTTAGGTTCTCAGTCAGCATTTACATTTAAAATCGTCATCCAATTAGGATCC
    GTCTTTGCAGCAGCATGGGTGTTCCGCGAACGCTTCTTAGAGATTTTACATATTGGTAAA
    CACAAACATGTTGAAGGAGATAACGATCAACAAAGACGTTCAAAGCCAAGACGTTTAAAT
    TTATTACATGTATTAGTGGGTATGGTGCCAGCAGGTATTTTAGGCTTACTATTTGATGAT
    TTCATCGAAGAACATTTATTTAGTGTGCCAACTGTTATGATTGGCTTATTCGTAGGTGCT
    ATCTATATGATTATTGCTGATAAATACTCAGCTAAAGTTAAAAACCCACAAACAGTAGAT
    CAAATCAGTTATTTCCAAGCATTTGTAATTGGTATTTCTCAAGCAGTAGCTATGTGGCCT
    GGTTTCAGCCGTTCAGGCTCAACAATTTCAACTGGGGTATTAATGAAATTAAATCATAAA
    GCAGCATCGGACTTTACATTTATTATGGCTGTTCCAATTATGTTAGCAGCTAGTGGTTTA
    TCTTTATTAAAACATTATCAAGATATTCAGATTGCTGATATACCTTTTTATATTTTAGGC
    TTTTTAGCTGCATTTACTGTTGGACTAATTGCAATCAAAACATTCTTGCATCAAATTAAC
    AAAATCAAACTAATTCCATTTGCCATTTACAGAATTGTATTAGTAATCTTTATTGCTATA
    CTTTACTTCGGATTTGGCATTGGTAAAGGTATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    876

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SACOL0743 [new locus tag: SACOL_RS03815 ]
  • symbol: UppP
  • description: UDP pyrophosphate phosphatase
  • length: 291
  • theoretical pI: 9.6824
  • theoretical MW: 32284.2
  • GRAVY: 0.703093

⊟Function[edit | edit source]

  • reaction:
    EC 3.6.1.27?  ExPASy
    Undecaprenyl-diphosphate phosphatase Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate
  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan undecaprenyl-diphosphatase UppP (TIGR00753; EC 3.6.1.27; HMM-score: 277)
    and 1 more
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions holin, BlyA family (TIGR01606; HMM-score: 11)
  • TheSEED  :
    • Undecaprenyl-diphosphatase (EC 3.6.1.27)
    Cell Wall and Capsule Gram-Positive cell wall components Teichoic and lipoteichoic acids biosynthesis  Undecaprenyl-diphosphatase (EC 3.6.1.27)
  • PFAM:
    LysE (CL0292) BacA; Bacitracin resistance protein BacA (PF02673; HMM-score: 262.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 6
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011413
    • TAT(Tat/SPI): 0.000345
    • LIPO(Sec/SPII): 0.003051
  • predicted transmembrane helices (TMHMM): 8

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MFIIELIKGIILGVVEGLTEFAPVSSTGHMILVDDMWLKSSEFLGSQSAFTFKIVIQLGSVFAAAWVFRERFLEILHIGKHKHVEGDNDQQRRSKPRRLNLLHVLVGMVPAGILGLLFDDFIEEHLFSVPTVMIGLFVGAIYMIIADKYSAKVKNPQTVDQISYFQAFVIGISQAVAMWPGFSRSGSTISTGVLMKLNHKAASDFTFIMAVPIMLAASGLSLLKHYQDIQIADIPFYILGFLAAFTVGLIAIKTFLHQINKIKLIPFAIYRIVLVIFIAILYFGFGIGKGI

⊟Experimental data[edit | edit source]

  • experimentally validated: PeptideAtlas
  • protein localization: Integral membrane [1] [2]
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
    A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
    PLoS One: 2009, 4(12);e8176
    [PubMed:19997597] [WorldCat.org] [DOI] (I e)
  2. ↑ Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
    The Staphylococcus aureus proteome.
    Int J Med Microbiol: 2014, 304(2);110-20
    [PubMed:24439828] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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