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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

organism: Staphylococcus aureus COL
locus tag: SACOL2342 [new locus tag: SACOL_RS12300 ]
pan locus tag^?: SAUPAN005846000
symbol: SACOL2342
pan gene symbol^?: corA
synonym:
product: magnesium and cobalt transport protein CorA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

type: CDS
locus tag: SACOL2342 [new locus tag: SACOL_RS12300 ]
symbol: SACOL2342
product: magnesium and cobalt transport protein CorA
replicon: chromosome
strand: -
coordinates: 2402115..2403062
length: 948
essential: unknown other strains

⊟Accession numbers[edit | edit source]

Gene ID: 3235997 NCBI
RefSeq: YP_187148 NCBI
BioCyc: see SACOL_RS12300
MicrobesOnline: 913823 MicrobesOnline

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

1
61
121
181
241
301
361
421
481
541
601
661
721
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841
901
ATGGCTTTAAAGATACGGTATCAAACTACATATGAACCGTTTAAAGTAGTTGATGATATC
AAAGAGATACCAAAAGATGCGACTATTGTTTGGTATGATTTTGATGAACCGAATGAACAA
GAAAATGAATGGTTTAAAGCACATTTTAATTTTAATGATTTAGAAGTGGATGATGCAATT
AACGGTATGCCACGAGCTAAATATAAATCTTATAAAGATTATCAATACTTAGTATTCCAT
AGTATTATGGGGTCAAACTATTCACCAATAGCACTAAATATTTTTATACAAGACAATGTA
TTAGTAACATATCATCATCAAACGTTGGAATCATTAAATAAAGTAGTCTATAAGTATATG
AATACATTAGATGCAGAATTAGATTGTGCAGATGTCGTCATATTAATTTTAGATATGATG
GTTGATAAATATTTCAACTTTGTATATGCACTTGAAGATAGTGTTTATCATTTTGAAGAC
CGCCATGTAGATGATCGCTTTAATAAAATGGTCATGGATAGTGTCTTTAAGTTACGTTCG
GATTTGATTAAAGTAAAACGTGTACTGTTTCCTATGCAAGAGCTAATTGATACAATGAAA
CAAAATGGTGATTTGATTATAGATAATAAACATTCGCTATACATTCAACATATCGATGAC
CACTTGATTAAGCAACGTAATATCATTCGTACTGCTCAAGAAATGACAAACGAAATACGA
GAAAATTTTGAGTCATACACGTCATTTAGAATGAATAGTATTATGCAAGTACTGACATTA
GTATCAGTTATATTTTCACCGTTAACATTCATAGCTGGGATTTATGGTATGAACTTTGTA
AATATGCCGGCATTACATTTACATTATGGATATTATATTTGCTTAGCTGTAATGTTTGTT
ATAGCTGTCGTATTAATCATCTTTTTCAGACGTAAAAAATGGTTTTAA
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948

⊟Protein[edit | edit source]

⊟General[edit | edit source]

locus tag: SACOL2342 [new locus tag: SACOL_RS12300 ]
symbol: SACOL2342
description: magnesium and cobalt transport protein CorA
length: 315
theoretical pI: 5.76074
theoretical MW: 37526.2
GRAVY: -0.067619

⊟Function[edit | edit source]

TIGRFAM:
Metabolism Transport and binding proteins Cations and iron carrying compounds magnesium and cobalt transport protein CorA (TIGR00383; HMM-score: 206.9)
TheSEED :
- Magnesium and cobalt transport protein CorA
PFAM:
no clan defined CorA; CorA-like Mg2+ transporter protein (PF01544; HMM-score: 244.6)
and 6 more
DUF2207; Predicted membrane protein (DUF2207) (PF09972; HMM-score: 17.9)
Transporter (CL0375) Claudin_2; PMP-22/EMP/MP20/Claudin tight junction (PF13903; HMM-score: 13.9)
GAG-polyprotein (CL0523) Retrotran_gag_2; gag-polypeptide of LTR copia-type (PF14223; HMM-score: 13.5)
no clan defined SlyX; SlyX (PF04102; HMM-score: 13.4)
Tetraspannin (CL0347) Tetraspannin; Tetraspanin family (PF00335; HMM-score: 11.2)
RND_permease (CL0322) MMPL; MMPL family (PF03176; HMM-score: 8)

⊟Structure, modifications & cofactors[edit | edit source]

domains:
modifications:
cofactors:
effectors:

⊟Localization[edit | edit source]

PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 0.04
- Cytoplasmic Membrane Score: 9.96
- Cellwall Score: 0
- Extracellular Score: 0
- Internal Helices: 2
LocateP: Multi-transmembrane
- Prediction by SwissProt Classification: Membrane
- Pathway Prediction: Sec-(SPI)
- Intracellular possibility: 0.17
- Signal peptide possibility: -1
- N-terminally Anchored Score: 1
- Predicted Cleavage Site: No CleavageSite
SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.002887
- TAT(Tat/SPI): 0.00014
- LIPO(Sec/SPII): 0.000381
predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

GI: 57650890 NCBI
RefSeq: YP_187148 NCBI
UniProt: A0A0H2WWV8 UniProt

⊟Protein sequence[edit | edit source]

MALKIRYQTTYEPFKVVDDIKEIPKDATIVWYDFDEPNEQENEWFKAHFNFNDLEVDDAINGMPRAKYKSYKDYQYLVFHSIMGSNYSPIALNIFIQDNVLVTYHHQTLESLNKVVYKYMNTLDAELDCADVVILILDMMVDKYFNFVYALEDSVYHFEDRHVDDRFNKMVMDSVFKLRSDLIKVKRVLFPMQELIDTMKQNGDLIIDNKHSLYIQHIDDHLIKQRNIIRTAQEMTNEIRENFESYTSFRMNSIMQVLTLVSVIFSPLTFIAGIYGMNFVNMPALHLHYGYYICLAVMFVIAVVLIIFFRRKKWF

⊟Experimental data[edit | edit source]

experimentally validated: PeptideAtlas
protein localization: Integral membrane ^[1] ^[2]
quantitative data / protein copy number per cell:
interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

MicrobesOnline: fni < SACOL2342

⊟Regulation[edit | edit source]

regulator:

⊟Transcription pattern[edit | edit source]

S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

Aureolib: no data available

⊟Protein stability[edit | edit source]

half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

↑ Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
PLoS One: 2009, 4(12);e8176
[PubMed:19997597] [WorldCat.org] [DOI] (I e)
↑ Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
The Staphylococcus aureus proteome.
Int J Med Microbiol: 2014, 304(2);110-20
[PubMed:24439828] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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