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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL2541 [new locus tag: SACOL_RS13305 ]
  • pan locus tag?: SAUPAN006179000
  • symbol: SACOL2541
  • pan gene symbol?: —
  • synonym:
  • product: acetyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SACOL2541 [new locus tag: SACOL_RS13305 ]
  • symbol: SACOL2541
  • product: acetyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 2600822..2601313
  • length: 492
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGATTAGATACGCTAAAAAAGAGGATTTAAACGCTATATTAGCGATATACAATGATGCC
    ATTATCAATACTACAGCTGTTTATACTTATGAACCACAAACCATAGACGAACGTGTCGCA
    TGGTTTGAAACGAAACAACGTAAGCATGAGCCTATCTTTGTATTTGAGGAAAATGGAAGT
    GTCTTAGGGTTTGCGACGTTCGGTTCATTTAGACCTTGGCCAGCATACCTATATACAATC
    GAACATTCTATTTATGTCGATGCTTCAGCTAGAGGAAAAGGTATTGCTAGTCAATTACTA
    CACCATTTAATTGTGGAAGCAAAAGCTAAAGGTTATCGTGCGCTAGTTGCAGGCATTGAT
    GCTTCCAACAAAGCGAGTATTCAGTTGCATCAAAAGTTTGCTTTTAAGCATGCCGGCACA
    CTGACCAATGTAGGTTTTAAATTTAATAGATGGTTAGATTTAGCATTTTACGAATTAGAT
    TTACAAGACTAG
    60
    120
    180
    240
    300
    360
    420
    480
    492

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SACOL2541 [new locus tag: SACOL_RS13305 ]
  • symbol: SACOL2541
  • description: acetyltransferase
  • length: 163
  • theoretical pI: 7.89534
  • theoretical MW: 18592
  • GRAVY: -0.149693

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal-protein-alanine acetyltransferase (TIGR01575; EC 2.3.1.128; HMM-score: 36.3)
    Cellular processes Cellular processes Adaptations to atypical conditions diaminobutyrate acetyltransferase (TIGR02406; EC 2.3.1.178; HMM-score: 31.5)
    and 2 more
    UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase (TIGR03585; EC 2.3.1.202; HMM-score: 21.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs mycothiol synthase (TIGR03448; EC 2.3.1.189; HMM-score: 12.8)
  • TheSEED  :
    • Phosphinothricin N-acetyltransferase (EC 2.3.1.-)
  • PFAM:
    Acetyltrans (CL0257) Acetyltransf_1; Acetyltransferase (GNAT) family (PF00583; HMM-score: 71.5)
    Acetyltransf_4; Acetyltransferase (GNAT) domain (PF13420; HMM-score: 67.4)
    and 8 more
    Acetyltransf_3; Acetyltransferase (GNAT) domain (PF13302; HMM-score: 50.7)
    Acetyltransf_7; Acetyltransferase (GNAT) domain (PF13508; HMM-score: 45.2)
    Acetyltransf_10; Acetyltransferase (GNAT) domain (PF13673; HMM-score: 26.2)
    FR47; FR47-like protein (PF08445; HMM-score: 23.5)
    Acetyltransf_CG; GCN5-related N-acetyl-transferase (PF14542; HMM-score: 23.2)
    Acetyltransf_9; Acetyltransferase (GNAT) domain (PF13527; HMM-score: 21.8)
    GNAT_acetyltran; GNAT acetyltransferase (PF12746; HMM-score: 20.7)
    Acetyltransf_13; ESCO1/2 acetyl-transferase (PF13880; HMM-score: 14.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9969
    • Cytoplasmic Membrane Score: 0.0004
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0026
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008907
    • TAT(Tat/SPI): 0.000185
    • LIPO(Sec/SPII): 0.001457
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MIRYAKKEDLNAILAIYNDAIINTTAVYTYEPQTIDERVAWFETKQRKHEPIFVFEENGSVLGFATFGSFRPWPAYLYTIEHSIYVDASARGKGIASQLLHHLIVEAKAKGYRALVAGIDASNKASIQLHQKFAFKHAGTLTNVGFKFNRWLDLAFYELDLQD

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization: Cytoplasmic [1]
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
    The Staphylococcus aureus proteome.
    Int J Med Microbiol: 2014, 304(2);110-20
    [PubMed:24439828] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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