Jump to navigation
Jump to search
PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40
⊟Summary[edit | edit source]
- pan ID?: SAUPAN000661000
- symbol?: lukS-PV
- synonym:
- description?: gamma-hemolysin subunit A
- gamma-hemolysin subunit A
- Panton-Valentine leukocidin, LukS-PV
- Panton-Valentine leukocidin subunit S
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 771901..2348509
- synteny block?: BlockID0003110
- occurrence?: in 6% of 34 strains
⊟Additional information (user-provided)[edit | edit source]
lukS-PV : prophage-encoded Panton-Valentine bi-component leukocidin subunit F [1]
• A crystal structure is available : 1T5R
LukSF Panton-Valentine leukocidin is a potent pore-forming toxin that lyses phagocytes that contain the human C5a receptor. The virulence factor is frequently carried on an int2 lipoprotein-converting prophage.
⊟Orthologs[edit | edit source]
COL:
—
N315:
—
NCTC8325:
—
04-02981:
—
08BA02176:
—
11819-97:
—
6850:
—
71193:
—
ECT-R 2:
—
ED133:
—
ED98:
—
HO 5096 0412:
—
JH1:
—
JH9:
—
JKD6008:
—
JKD6159:
—
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
—
Mu3:
—
Mu50:
—
MW2:
—
RF122:
—
ST398:
—
T0131:
—
TCH60:
—
TW20:
—
USA300_TCH1516:
USA300HOU_1431 (lukS-PV)
VC40:
—
⊟Genome Viewer[edit | edit source]
⊟Alignments[edit | edit source]
- alignment of orthologues:
⊟Literature[edit | edit source]
- ↑ Karita Haapasalo, Adam J M Wollman, Carla J C de Haas, Kok P M van Kessel, Jos A G van Strijp, Mark C Leake
Staphylococcus aureus toxin LukSF dissociates from its membrane receptor target to enable renewed ligand sequestration.
FASEB J: 2019, 33(3);3807-3824
[PubMed:30509126] [WorldCat.org] [DOI] (I p)