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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001019000
- symbol?: —
- synonym:
- description?: 4'-phosphopantetheinyl transferase
- 4'-phosphopantetheinyl transferase
- 4'-phosphopantetheinyl transferase superfamily protein
- sfp-type 4-phosphopantetheinyl transferase family protein
- 4'-phosphopantetheinyl transferase family protein
- 4'-phosphopantetheinyl transferase-like protein
- holo-[acyl-carrier-protein] synthase
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1291630..1292274
- synteny block?: BlockID0005470
- occurrence?: in 100% of 34 strains
ausB : phosphopantetheinyl transferase AusB [1]
Staphylococci assemble dipeptide-derived pyrazinones using a modified nonribosomal peptide synthetase system. AusB transfers CoA-derived 4'-phosphopantetheine posttranslational modifications onto apo-peptidyl carrier protein domains of AusA to generate a functional aureusimine (pyrazinone) synthetase.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0181
08BA02176:
C248_0169
11819-97:
MS7_0173
6850:
RSAU_000131
71193:
ST398NM01_0194
ECT-R 2:
ECTR2_143
ED133:
SAOV_0124
ED98:
SAAV_0148
HO 5096 0412:
SAEMRSA15_01450
JH1:
SaurJH1_0170
JH9:
SaurJH9_0165
JKD6008:
SAA6008_00158
JKD6159:
SAA6159_00161
JSNZ:
JSNZ_000122
LGA251:
SARLGA251_01510
M013:
M013TW_0167
MRSA252:
SAR0181
MSHR1132:
SAMSHR1132_01530
MSSA476:
SAS0155
Mu3:
SAHV_0179
Mu50:
SAV0180
MW2:
MW0154
RF122:
SAB0120
ST398:
SAPIG0194
T0131:
SAT0131_00171 (era)
TCH60:
HMPREF0772_10319 (acpS)
TW20:
SATW20_01900
USA300_TCH1516:
USA300HOU_0193
VC40:
SAVC_00665
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTVFVMQLQSNLKSIEELISQSRWSYKKPRTVNYRYNQDKLMHRLGDILVQYGIQHDTGL
N315 MTVFVMQLQSNLKSIEELISQSRWSYKKPRTVNYRYNQDKLMHRLGDILVQYGIQHDTGL
NCTC8325 MTVFVMQLQSNLKSIEELISQSRWSYKKPRTVNYRYNQDKLMHRLGDILVQYGIQHDTGL
Newman MTVFVMQLQSNLKSIEELISQSRWSYKKPRTVNYRYNQDKLMHRLGDILVQYGIQHDTGL
USA300_FPR3757 MTVFVMQLQSNLKSIEELISQSRWSYKKPRTVNYRYNQDKLMHRLGDILVQYGIQHDTGL
************************************************************
COL LPHEWHYHISPRGKADIVQHNRDGQPIYVSLSYSYPYIVCVVDKEPVGIDIEKISQRLDW
N315 LPHEWHYHISPRGKADIVQHNRDGQPIYVSLSYSYPYIVCVVDKEPVGIDIEKISQRLDW
NCTC8325 LPHEWHYHISPRGKADIVQHNRDGQPIYVSLSYSYPYIVCVVDKEPVGIDIEKISQRLDW
Newman LPHEWHYHISPRGKADIVQHNRDGQPIYVSLSYSYPYIVCVVDKEPVGIDIEKISQRLDW
USA300_FPR3757 LPHEWHYHISPRGKADIVQHNRDGQPIYVSLSYSYPYIVCVVDKEPVGIDIEKISQRLDW
************************************************************
COL RTLVTCFSTNEAHQICSLNDFYQIWTQKESFTKLIGEGLIKGLDIYDMTQSHFYQSREVK
N315 RTLVTCFSTNEAHQICSLNDFYQIWTQKESFTKLIGEGLIKGLDIYDMTQSHFYQSREVK
NCTC8325 RTLVTCFSTNEAHQICSLNDFYQIWTQKESFTKLIGEGLIKGLDIYDMTQSHFYQSREVK
Newman RTLVTCFSTNEAHQICSLNDFYQIWTQKESFTKLIGEGLIKGLDIYDMTQSHFYQSREVK
USA300_FPR3757 RTLVTCFSTNEAHQICSLNDFYQIWTQKESFTKLIGEGLIKGLDIYDMTQSHFYQSREVK
************************************************************
COL FKQFIFDQFMVQVCFLGQAPWGYKKVSVFQLLSS
N315 FKQFIFDQFMVQVCFLGEAPWGYKKVSVFQLLSS
NCTC8325 FKQFIFDQFMVQVCFLGQAPWGYKKVSVFQLLSS
Newman FKQFIFDQFMVQVCFLGQAPWGYKKVSVFQLLSS
USA300_FPR3757 FKQFIFDQFMVQVCFLGQAPWGYKKVSVFQLLSS
*****************:****************
- ↑ Morgan A Wyatt, Wenliang Wang, Christelle M Roux, Federico C Beasley, David E Heinrichs, Paul M Dunman, Nathan A Magarvey
Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence.
Science: 2010, 329(5989);294-6
[PubMed:20522739] [WorldCat.org] [DOI] (I p)