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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001073000
- symbol?: —
- synonym:
- description?: membrane protein
- membrane protein
- isoprenylcysteine carboxyl methyltransferase family protein
- isoprenylcysteine carboxyl methyltransferase
- isoprenylcysteine carboxyl methyltransferase (ICMT) family protein
- membrane spanning protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 1349640..1350134
- synteny block?: BlockID0005950
- occurrence?: in 100% of 33 strains
icmT: isoprenylcysteine carboxyl methyltransferase [1]
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0221
08BA02176:
C248_0204
11819-97:
MS7_0206
6850:
RSAU_000164
71193:
ST398NM01_0230
ECT-R 2:
ECTR2_181
ED133:
SAOV_0158
ED98:
SAAV_0186
HO 5096 0412:
SAEMRSA15_01790
JH1:
SaurJH1_0211
JH9:
SaurJH9_0205
JKD6008:
SAA6008_00189
JKD6159:
SAA6159_00195
LGA251:
SARLGA251_01840
M013:
M013TW_0200
MRSA252:
SAR0212
MSHR1132:
SAMSHR1132_01860
MSSA476:
SAS0196
Mu3:
SAHV_0219
Mu50:
SAV0220
MW2:
MW0196
RF122:
SAB0159c
ST398:
SAPIG0230
T0131:
SAT0131_00206
TCH60:
HMPREF0772_10287
TW20:
SATW20_02210
USA300_TCH1516:
USA300HOU_0228
VC40:
SAVC_00840
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTSFIYKILYVVKINAYTYDIMTEDIMILSILLIFFCIRLVSLKISINHSKQLKADGAVE
N315 --------------------------MILSILLIFFCIRLVSLKISINHSKQLKADGAVE
NCTC8325 MTSFIYKILYVVKINAYTYDIMTEDIMILSILLIFFCIRLVSLKISINHSKQLKADGAVE
Newman MTSFIYKILYVVKINAYTYDIMTEDIMILSILLIFFCIRLVSLKISINHSKQLKADGAVE
USA300_FPR3757 MTSFIYKILYVVKINAYTYDIMTEDIMILSILLIFFCIRLVSLKISINHSKQLKADGAVE
**********************************
COL YGVKNSKFLAITHVLIYVLAGVEAFINKDTFSFANGIGLVILIFAYIMLFMVIKTLGGIW
N315 YGVKNSKFLAITHVLIYVLAGVEAFINKDTFSFANGIGLVILIFAYIMLFMVIKTLGGIW
NCTC8325 YGVKNSKFLAITHVLIYVLAGVEAFINKDTFSFANGIGLVILIFAYIMLFMVIKTLGGIW
Newman YGVKNSKFLAITHVLIYVLAGVEAFINKDTFSFANGIGLVILIFAYIMLFMVIKTLGGIW
USA300_FPR3757 YGVKNSKFLAITHVLIYVLAGVEAFINKDTFSFANGIGLVILIFAYIMLFMVIKTLGGIW
************************************************************
COL TLKLFILPNHPIIKSGLYKITKHPNYFLNIIPELIGVLLLTHATYTTILLVPYAYFLYVR
N315 TLKLFILPNHPIIKSGLYKITKHPNYFLNIIPELIGVLLLTHATYTTILLVPYAYFLYVR
NCTC8325 TLKLFILPNHPIIKSGLYKITKHPNYFLNIIPELIGVLLLTHATYTTILLVPYAYFLYVR
Newman TLKLFILPNHPIIKSGLYKITKHPNYFLNIIPELIGVLLLTHATYTTILLVPYAYFLYVR
USA300_FPR3757 TLKLFILPNHPIIKSGLYKITKHPNYFLNIIPELIGVLLLTHATYTTILLVPYAYFLYVR
************************************************************
COL IKQEEKLMNI
N315 IKQEEKLMNI
NCTC8325 IKQEEKLMNI
Newman IKQEEKLMNI
USA300_FPR3757 IKQEEKLMNI
**********
- ↑ Jing Yang, Kiran Kulkarni, Ioannis Manolaridis, Ziguo Zhang, Roger B Dodd, Corine Mas-Droux, David Barford
Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT.
Mol Cell: 2011, 44(6);997-1004
[PubMed:22195972] [WorldCat.org] [DOI] (I p)Christina N Krute, Ronan K Carroll, Frances E Rivera, Andy Weiss, Ryan M Young, Andrew Shilling, Mohsen Botlani, Sameer Varma, Bill J Baker, Lindsey N Shaw
The disruption of prenylation leads to pleiotropic rearrangements in cellular behavior in Staphylococcus aureus.
Mol Microbiol: 2015, 95(5);819-32
[PubMed:25491272] [WorldCat.org] [DOI] (I p)