Jump to navigation
Jump to search
⊟Summary[edit | edit source]
- pan ID?: SAUPAN001179000
- symbol?: essB
- synonym:
- description?: protein EssB
- protein EssB
- type VII secretion protein EssB
- Putative secretion system component EssB/YukC
- virulence protein EssB
- membrane associated protein
- putative secretion system component EssB
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1447360..1448694
- synteny block?: BlockID0006980
- occurrence?: in 100% of 34 strains
essB : type VIIb/ESAT-6 secretion translocon transmembrane component EssB [1]
• A crystal structure is available : 4ANN
• Staphylococcus aureus encodes a toxin secretion system called either the "Type VIIb Secretion" or "ESAT-6" pathway. EsxBCD surround the toxin "cargo" and the Esx-cargo complex is loaded onto a "translocon" system for transport across the staphylococcal membrane. A dedicated peptidoglycan amidase/endopeptidase (EssH) hydrolyzes the cell wall to allow translocated (exported) cargo access to the extracellular environment.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0286 (essB)
08BA02176:
C248_0276 (essB)
11819-97:
MS7_0277 (essB)
6850:
RSAU_000232 (essB)
71193:
ST398NM01_0301
ECT-R 2:
ECTR2_247
ED133:
SAOV_0229
ED98:
SAAV_0254
HO 5096 0412:
SAEMRSA15_02450
JH1:
SaurJH1_0277
JH9:
SaurJH9_0270
JKD6008:
SAA6008_00260 (essB)
JKD6159:
SAA6159_00267 (essB)
JSNZ:
JSNZ_000230 (essB)
LGA251:
SARLGA251_02500 (essB)
M013:
M013TW_0267
MRSA252:
SAR0283
MSHR1132:
SAMSHR1132_02540
MSSA476:
SAS0262
Mu3:
SAHV_0284
Mu50:
SAV0286
MW2:
MW0262
RF122:
SAB0227
ST398:
SAPIG0301
T0131:
SAT0131_00282
TCH60:
HMPREF0772_10214 (essB)
TW20:
SATW20_02880 (essB)
USA300_TCH1516:
USA300HOU_0301 (essB)
VC40:
SAVC_01180
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFID
N315 MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFID
NCTC8325 MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFID
Newman MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFID
USA300_FPR3757 MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFID
************************************************************
COL AELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDE
N315 AELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDE
NCTC8325 AELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDE
Newman AELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDE
USA300_FPR3757 AELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDE
************************************************************
COL LFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHK
N315 LFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHK
NCTC8325 LFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHK
Newman LFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHK
USA300_FPR3757 LFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHK
************************************************************
COL GTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVL
N315 GTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVL
NCTC8325 GTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVL
Newman GTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVL
USA300_FPR3757 GTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVL
************************************************************
COL LIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQ
N315 LIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQ
NCTC8325 LIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQ
Newman LIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQ
USA300_FPR3757 LIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQ
************************************************************
COL TNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALIN
N315 TNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALIN
NCTC8325 TNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALIN
Newman TNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALIN
USA300_FPR3757 TNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALIN
************************************************************
COL KLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQE
N315 KLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQE
NCTC8325 KLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQE
Newman KLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQE
USA300_FPR3757 KLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQE
************************************************************
COL ENEKKQKEQAQKDKEKRQEAERKK
N315 ENEKKQKEQAQKDKEKRQEAERKK
NCTC8325 ENEKKQKEQAQKDKEKRQEAERKK
Newman ENEKKQKEQAQKDKEKRQEAERKK
USA300_FPR3757 ENEKKQKEQAQKDKEKRQEAERKK
************************
- ↑ Manar M Ahmed, Khaled M Aboshanab, Yasser M Ragab, Dominique M Missiakas, Khaled A Aly
The transmembrane domain of the Staphylococcus aureus ESAT-6 component EssB mediates interaction with the integral membrane protein EsaA, facilitating partially regulated secretion in a heterologous host.
Arch Microbiol: 2018, 200(7);1075-1086
[PubMed:29737367] [WorldCat.org] [DOI] (I p)Maksym Bobrovskyy, So Young Oh, Dominique Missiakas
Contribution of the EssC ATPase to the assembly of the type 7b secretion system in Staphylococcus aureus.
J Biol Chem: 2022, 298(9);102318
[PubMed:35921891] [WorldCat.org] [DOI] (I p)