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Summary[edit | edit source]

  • pan ID?: SAUPAN001179000
  • symbol?: essB
  • synonym:
  • description?: protein EssB

      descriptions from strain specific annotations:

    • protein EssB
    • type VII secretion protein EssB
    • Putative secretion system component EssB/YukC
    • virulence protein EssB
    • membrane associated protein
    • putative secretion system component EssB
  • strand?: +
  • coordinates?: 1447360..1448694
  • synteny block?: BlockID0006980
  • occurrence?: in 100% of 34 strains

essB : type VIIb/ESAT-6 secretion translocon transmembrane component EssB [1]

• A crystal structure is available : 4ANN

Staphylococcus aureus encodes a toxin secretion system called either the "Type VIIb Secretion" or "ESAT-6" pathway. EsxBCD surround the toxin "cargo" and the Esx-cargo complex is loaded onto a "translocon" system for transport across the staphylococcal membrane. A dedicated peptidoglycan amidase/endopeptidase (EssH) hydrolyzes the cell wall to allow translocated (exported) cargo access to the extracellular environment.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_0286 (essB)
    08BA02176:
    C248_0276 (essB)
    11819-97:
    MS7_0277 (essB)
    6850:
    RSAU_000232 (essB)
    71193:
    ST398NM01_0301
    ECT-R 2:
    ECTR2_247
    ED133:
    SAOV_0229
    ED98:
    SAAV_0254
    HO 5096 0412:
    SAEMRSA15_02450
    JH1:
    SaurJH1_0277
    JH9:
    SaurJH9_0270
    JKD6008:
    SAA6008_00260 (essB)
    JKD6159:
    SAA6159_00267 (essB)
    JSNZ:
    JSNZ_000230 (essB)
    LGA251:
    SARLGA251_02500 (essB)
    M013:
    M013TW_0267
    MRSA252:
    SAR0283
    MSHR1132:
    SAMSHR1132_02540
    MSSA476:
    SAS0262
    Mu3:
    SAHV_0284
    Mu50:
    SAV0286
    MW2:
    MW0262
    RF122:
    SAB0227
    ST398:
    SAPIG0301
    T0131:
    SAT0131_00282
    TCH60:
    HMPREF0772_10214 (essB)
    TW20:
    SATW20_02880 (essB)
    USA300_TCH1516:
    USA300HOU_0301 (essB)
    VC40:
    SAVC_01180

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFID
    N315            MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFID
    NCTC8325        MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFID
    Newman          MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFID
    USA300_FPR3757  MVKNHNPKNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFID
                    ************************************************************

    COL             AELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDE
    N315            AELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDE
    NCTC8325        AELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDE
    Newman          AELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDE
    USA300_FPR3757  AELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDE
                    ************************************************************

    COL             LFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHK
    N315            LFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHK
    NCTC8325        LFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHK
    Newman          LFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHK
    USA300_FPR3757  LFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHK
                    ************************************************************

    COL             GTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVL
    N315            GTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVL
    NCTC8325        GTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVL
    Newman          GTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVL
    USA300_FPR3757  GTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVL
                    ************************************************************

    COL             LIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQ
    N315            LIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQ
    NCTC8325        LIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQ
    Newman          LIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQ
    USA300_FPR3757  LIAFLAFLYFSVMKHNERIEKGYQAFVKDDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQ
                    ************************************************************

    COL             TNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALIN
    N315            TNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALIN
    NCTC8325        TNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALIN
    Newman          TNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALIN
    USA300_FPR3757  TNKQGLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDITKLALIN
                    ************************************************************

    COL             KLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQE
    N315            KLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQE
    NCTC8325        KLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQE
    Newman          KLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQE
    USA300_FPR3757  KLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQE
                    ************************************************************

    COL             ENEKKQKEQAQKDKEKRQEAERKK
    N315            ENEKKQKEQAQKDKEKRQEAERKK
    NCTC8325        ENEKKQKEQAQKDKEKRQEAERKK
    Newman          ENEKKQKEQAQKDKEKRQEAERKK
    USA300_FPR3757  ENEKKQKEQAQKDKEKRQEAERKK
                    ************************

  1. Manar M Ahmed, Khaled M Aboshanab, Yasser M Ragab, Dominique M Missiakas, Khaled A Aly
    The transmembrane domain of the Staphylococcus aureus ESAT-6 component EssB mediates interaction with the integral membrane protein EsaA, facilitating partially regulated secretion in a heterologous host.
    Arch Microbiol: 2018, 200(7);1075-1086
    [PubMed:29737367] [WorldCat.org] [DOI] (I p)
    Maksym Bobrovskyy, So Young Oh, Dominique Missiakas
    Contribution of the EssC ATPase to the assembly of the type 7b secretion system in Staphylococcus aureus.
    J Biol Chem: 2022, 298(9);102318
    [PubMed:35921891] [WorldCat.org] [DOI] (I p)