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Summary[edit | edit source]

  • pan ID?: SAUPAN001200000
  • symbol?:
  • synonym:
  • description?: TIGR01741 family protein

      descriptions from strain specific annotations:

    • TIGR01741 family protein
    • Repetitive hypothetical protein
  • strand?: +
  • coordinates?: 1470014..1480470
  • synteny block?: BlockID0007140
  • occurrence?: in 68% of 34 strains

essI (esaG) : tandem EssD nuclease immunity protein paralogue [1]

• This locus is highly prone to recombination leading to gene duplication / loss. Gene nomenclature is confusing and appears to be numbered sequentially by position in the genome and is not intended to show homology between strains (e.g. the first instance of essI/esaG in COL may have the greatest homology with the sixth instance in FPR3757 but the gene names would still be different [i.e. essI1/esaG1 and essI6/esaG6 in COL and FPR3757, respectively]). Likewise, pseudogenes are frequent and assigned gene nomenclature in this locus. As appropriate, please append a numeral to the gene names provided here consistent with the number of gene duplications in your genome of interest.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_0297
    08BA02176:
    C248_0285
    11819-97:
    6850:
    71193:
    ST398NM01_0310
    ECT-R 2:
    ECTR2_258
    ED133:
    ED98:
    SAAV_0265
    HO 5096 0412:
    JH1:
    SaurJH1_0288
    JH9:
    SaurJH9_0281
    JKD6008:
    SAA6008_00270
    JKD6159:
    JSNZ:
    JSNZ_000240
    LGA251:
    M013:
    MRSA252:
    SAR0293
    MSHR1132:
    MSSA476:
    SAS0269
    Mu3:
    SAHV_0295
    Mu50:
    SAV0298
    MW2:
    MW0269
    RF122:
    ST398:
    SAPIG0310
    T0131:
    SAT0131_00294 (tgt)
    TCH60:
    HMPREF0772_10204
    TW20:
    SATW20_02980
    USA300_TCH1516:
    USA300HOU_0312
    VC40:

Genome Viewer[edit | edit source]

COL
N315
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MTFEEKLSEMYSEIANKISSMIPVEWEKVYAMAYIDDGGGEVFYYYTEPGSNELYYYTSV
    N315            MTFEEKLSQMYNEIANKISSMIPVEWEKVYTMAYIDDEGGEVFYYYTEPGSNELYYYTSV
    Newman          MTFEEKLSEMYSEIANKISSMIPVEWEKVYAMAYIDDGGGEVFYYYTEPGSNELYYYTSV
    USA300_FPR3757  MTFEEKLSEMYSEIANKISSMIPVEWEKVYAMAYIDDGGGEVFYYYTEPGSNELYYYTSV
                    ********:**.******************:****** **********************

    COL             LNKYDISESEFMDSVYELYKQFQNLRNLFKEEGHEPWTSCEFDFTREGELKVSFDYIDWI
    N315            LNKYDISESEFMDSAYELYKQFQNLRNIFKEEGYEPWTSCEFDFTKEGELKVSFDYIDWI
    Newman          LNKYDISESEFMDSVYELYKQFQNLRNLFKEEGHEPWTSCEFDFTREGELKVSFDYIDWI
    USA300_FPR3757  LNKYDISESEFMDSVYELYKQFQNLRNLFKEEGHEPWTSCEFDFTREGELKVSFDYIDWI
                    **************.************:*****:***********:**************

    COL             NSEFGQVGRQNYYKYRKFGILPETEYEINKVKEIEQYVKEQEEAEQ
    N315            NTEFDQLGRQNYYMYKKFGVIPEMEYEMEEVKEIEQYIKEQEEAEQ
    Newman          NSEFGQVGRQNYYKYRKFGILPETEYEINKVKEIEQYVKEQEEAEQ
    USA300_FPR3757  NSEFGQVGRQNYYKYRKFGILPETEYEINKVKEIEQYVKEQEEAEQ
                    *:**.*:****** *:***::** ***:::*******:********

  1. Ryan Jay Ohr, Mark Anderson, Miaomiao Shi, Olaf Schneewind, Dominique Missiakas
    EssD, a Nuclease Effector of the Staphylococcus aureus ESS Pathway.
    J Bacteriol: 2017, 199(1);
    [PubMed:27795323] [WorldCat.org] [DOI] (I e)
    Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
    Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
    Microb Genom: 2022, 8(8);
    [PubMed:35960642] [WorldCat.org] [DOI] (I p)