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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN001498000
  • symbol?:
  • synonym:
  • description?: phage protein
  • strand?: -
  • coordinates?: 1750797..1751117
  • synteny block?: BlockID0009730
  • occurrence?: in 18% of 34 strains

hypothetical phi69 ORF45-like DUF771 phage protein [1]

Although originally suspected to be the toxin component of a toxin-antitoxin system, the proposed antitoxin component is actually the MurG inhibitor toxin Gp11. This leaves the functional role of this HigB homologue unclear.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    08BA02176:
    11819-97:
    6850:
    71193:
    ECT-R 2:
    ED133:
    ED98:
    SAAV_2056
    HO 5096 0412:
    JH1:
    JH9:
    JKD6008:
    JKD6159:
    SAA6159_01924
    JSNZ:
    LGA251:
    M013:
    MRSA252:
    MSHR1132:
    SAMSHR1132_18340
    MSSA476:
    Mu3:
    Mu50:
    MW2:
    RF122:
    ST398:
    T0131:
    TCH60:
    TW20:
    USA300_TCH1516:
    USA300HOU_1997
    VC40:

Genome Viewer[edit | edit source]

Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    Newman          MPHILNVTVPIPETHVLITKDEYDELIGYSLDPVWNMSDLKKKLKIASDETIKDRLLFHP
    USA300_FPR3757  MPHILNVTVPIPETHVLITKDEYDELIGYSLDPVWNMSDLKKKLKIASDETIKDRLLFHP
                    ************************************************************

    Newman          RFEKELRAQGIVHYPDENFNRWRFNARKMNKFVDEHFNEIYKERIK
    USA300_FPR3757  RFEKELRAQGIVHYPDESFNRWRFNARKMNKFVDEHFNEIYKERIK
                    *****************.****************************

  1. Gul Habib, Qing Zhu, Baolin Sun
    Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus.
    Toxins (Basel): 2018, 10(11);
    [PubMed:30441856] [WorldCat.org] [DOI] (I e)
    Qi Xu, Li Tang, Weilin Liu, Neng Xu, Yangbo Hu, Yong Zhang, Shiyun Chen
    Phage protein Gp11 blocks Staphylococcus aureus cell division by inhibiting peptidoglycan biosynthesis.
    mBio: 2024, 15(6);e0067924
    [PubMed:38752726] [WorldCat.org] [DOI] (I p)