PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

⊟Summary

• pan ID^?: SAUPAN002175000
• symbol^?: mccB
• synonym:
• description^?: cystathionine gamma-synthase

  descriptions from strain specific annotations:

  • cystathionine gamma-synthase
  • trans-sulfuration enzyme family protein
  • bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase
  • cystathionine gamma-synthase, putative
  • Cystathionine gamma-lyase
  • putative Cys/Met metabolism PLP-dependentenzyme
  • bifunctional cystathionine gamma-lyase/gamma-synthase
  • Cys/Met metabolism PLP-dependent enzyme
  • cystathionine beta-lyase
  • cystathionine gamma-lyase (Gamma-cystathionase)(Probasin-related antigen) (PRB-RA)
  • cystathionine gamma-synthase (CGS) (O-succinylhomoserine(thiol)-lyase)
  • cystathionine gamma-synthase-like protein
• strand^?: +
• coordinates^?: 2678887..2680101
• synteny block^?: BlockID0014760
• occurrence^?: in 97% of 33 strains

⊟Orthologs

COL:
SACOL0503
N315:
SA0419 (metB)
NCTC8325:
SAOUHSC_00422
Newman:
NWMN_0425 (metB)
USA300_FPR3757:
SAUSA300_0434 (metB)
04-02981:
SA2981_0436 (metB)
08BA02176:
C248_0510
11819-97:
MS7_0434 (mccB)
6850:
RSAU_000393
71193:
ST398NM01_0526
ECT-R 2:
ECTR2_394
ED133:
SAOV_0478
ED98:
SAAV_0403
HO 5096 0412:
SAEMRSA15_03860
JH1:
SaurJH1_0495
JH9:
SaurJH9_0482
JKD6008:
SAA6008_00464 (metB)
JKD6159:
SAA6159_00410 (metB)
LGA251:
SARLGA251_03940
M013:
M013TW_0425
MRSA252:
SAR0460
MSHR1132:
SAMSHR1132_04050
MSSA476:
SAS0418
Mu3:
SAHV_0458 (yrhB)
Mu50:
SAV0460 (yrhB)
MW2:
MW0415 (metB)
RF122:
SAB0410
ST398:
SAPIG0526
T0131:
SAT0131_00500
TCH60:
HMPREF0772_10062 (metC)
TW20:
SATW20_05290
USA300_TCH1516:
—
VC40:
SAVC_01890

⊟Genome Viewer

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
  
  
  COL             MNKKTKLIHGGHTTDDYTGAVTTPIYQTSTYLQDDIGDLRQGYEYSRTANPTRSSVESVI
  N315            MNKKTKLIHGGHTTDDYTGAVTTPIYQTSTYLQDDIGDLRQGYEYSRTANPTRSSVESVI
  NCTC8325        MNKKTKLIHGGHTTDDYTGAVTTPIYQTSTYLQDDIGDLRQGYEYSRTANPTRSSVESVI
  Newman          MNKKTKLIHGGHTTDDYTGAVTTPIYQTSTYLQDDIGDLRQGYEYSRTANPTRSSVESVI
  USA300_FPR3757  MNKKTKLIHGGHTTDDYTGAVTTPIYQTSTYLQDDIGDLRQGYEYSRTANPTRSSVESVI
                  ************************************************************
  
  COL             ATLENGKHGFAFSSGVAAISAVVMLLDKGDHIILNSDVYGGTYRALTKVFTRFGIEVDFV
  N315            AALENGKHGFAFSSGVAAISAVVMLLDKGDHIILNSDVYGGTYRALTKVFTRFGIEVDFV
  NCTC8325        ATLENGKHGFAFSSGVAAISAVVMLLDKGDHIILNSDVYGGTYRALTKVFTRFGIEVDFV
  Newman          ATLENGKHGFAFSSGVAAISAVVMLLDKGDHIILNSDVYGGTYRALTKVFTRFGIEVDFV
  USA300_FPR3757  ATLENGKHGFAFSSGVAAISAVVMLLDKGDHIILNSDVYGGTYRALTKVFTRFGIEVDFV
                  *:**********************************************************
  
  COL             DTTHTDSIVQAIRPTTKMLFIETPSNPLLRVTDIKKSAEIAKEHGLISVVDNTFMTPYYQ
  N315            DTTHTDSIVQAIRPTTKMLFIETPSNPLLRVTDIKKSAEIAKEHGLISVVDNTFMTPYYQ
  NCTC8325        DTTHTDSIVQAIRPTTKMLFIETPSNPLLRVTDIKKSAEIAKEHGLISVVDNTFMTPYYQ
  Newman          DTTHTDSIVQAIRPTTKMLFIETPSNPLLRVTDIKKSAEIAKEHGLISVVDNTFMTPYYQ
  USA300_FPR3757  DTTHTDSIVQAIRPTTKMLFIETPSNPLLRVTDIKKSAEIAKEHGLISVVDNTFMTPYYQ
                  ************************************************************
  
  COL             NPLDLGIDIVLHSATKYLGGHSDVVAGLVATSDDKLAERLAFISNSTGGILGPQDSYLLV
  N315            NPLDLGIDIVLHSATKYLGGHSDVVAGLVATSDDKLAERLAFISNSTGGILGPQDSYLLV
  NCTC8325        NPLDLGIDIVLHSATKYLGGHSDVVAGLVATSDDKLAERLAFISNSTGGILGPQDSYLLV
  Newman          NPLDLGIDIVLHSATKYLGGHSDVVAGLVATSDDKLAERLAFISNSTGGILGPQDSYLLV
  USA300_FPR3757  NPLDLGIDIVLHSATKYLGGHSDVVAGLVATSDDKLAERLAFISNSTGGILGPQDSYLLV
                  ************************************************************
  
  COL             RGIKTLGLRMEQINRSVIEIIKMLQAHPAVQQVFHPSIESHLNHDVHMAQADGHTGVIAF
  N315            RGIKTLGLRMEQINRSVIEIIKMLQAHPAVQQVFHPSIESHLNHDVHMAQADGHTGVIAF
  NCTC8325        RGIKTLGLRMEQINRSVIEIIKMLQAHPAVQQVFHPSIESHLNHDVHMAQADGHTGVIAF
  Newman          RGIKTLGLRMEQINRSVIEIIKMLQAHPAVQQVFHPSIESHLNHDVHMAQADGHTGVIAF
  USA300_FPR3757  RGIKTLGLRMEQINRSVIEIIKMLQAHPAVQQVFHPSIESHLNHDVHMAQADGHTGVIAF
                  ************************************************************
  
  COL             EVKNTESAKQLIKATSYYTLAESLGAVESLISVPALMTHASIPADIRAKEGITDGLVRIS
  N315            EVKNTESAKQLIKATSYYTLAESLGAVESLISVPALMTHASIPADIRAKEGITDGLVRIS
  NCTC8325        EVKNTESAKQLIKATSYYTLAESLGAVESLISVPALMTHASIPADIRAKEGITDGLVRIS
  Newman          EVKNTESAKQLIKATSYYTLAESLGAVESLISVPALMTHASIPADIRAKEGITDGLVRIS
  USA300_FPR3757  EVKNTESAKQLIKATSYYTLAESLGAVESLISVPALMTHASIPADIRAKEGITDGLVRIS
                  ************************************************************
  
  COL             VGIEDTEDLVDDLKQALDTL
  N315            VGIEDTEDLVDDLKQALDTL
  NCTC8325        VGIEDTEDLVDDLKQALDTL
  Newman          VGIEDTEDLVDDLKQALDTL
  USA300_FPR3757  VGIEDTEDLVDDLKQALDTL
                  ********************