⊟Summary[edit | edit source]
- pan ID?: SAUPAN002518000
- symbol?: tagD
- synonym:
- description?: glycerol-3-phosphate cytidylyltransferase
- glycerol-3-phosphate cytidylyltransferase
- glycerol-3-phosphate cytidylyltransferase, putative
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3030164..3030562
- synteny block?: BlockID0017540
- occurrence?: in 100% of 34 strains
tarD (tagD) : glycerol-3-phosphate cytidylyltransferase [1]
• A crystal structure is available : 2B7L
TarD provides a pool of CDP-activated glycerol-3-phosphate for TarB to use for UDP-disaccharide glycerophosphate priming. Wall teichoic acids in S. aureus use ribitol exclusively as their polyol extension monomer, therefore WTA enzymes in S. aureus are assigned the "tar" nomenclature. In contrast, S. epidermidis uses glycerol as its polyol extension monomer so orthologous enzymes in S. epidermidis are assigned the "tag" nomenclature. The utilization of glycerol phosphate by TarB and TarD for polyol priming further blurs the line between the "Tar" and the "Tag" nomenclature but because the polymerizing polyol will be ribitol, the enzymes retain the "Tar" nomenclature.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKRVITYGTYDLLHYGHIELLRRAREMGDYLIVALSTDEFNQIKHKKSYYDYEQRKMMLE
N315 MKRVITYGTYDLLHYGHIELLRRAREMGDYLIVALSTDEFNQIKHKKSYYDYEQRKMMLE
NCTC8325 MKRVITYGTYDLLHYGHIELLRRAREMGDYLIVALSTDEFNQIKHKKSYYDYEQRKMMLE
Newman MKRVITYGTYDLLHYGHIELLRRAREMGDYLIVALSTDEFNQIKHKKSYYDYEQRKMMLE
USA300_FPR3757 MKRVITYGTYDLLHYGHIELLRRAREMGDYLIVALSTDEFNQIKHKKSYYDYEQRKMMLE
************************************************************
COL SIRYVDLVIPEKGWGQKEDDVEKFDVDVFVMGHDWEGEFDFLKDKCEVIYLKRTEGISTT
N315 SIRYVDLVIPEKGWGQKEDDVEKFDVDVFVMGHDWEGEFDFLKDKCEVIYLKRTEGISTT
NCTC8325 SIRYVDLVIPEKGWGQKEDDVEKFDVDVFVMGHDWEGEFDFLKDKCEVIYLKRTEGISTT
Newman SIRYVDLVIPEKGWGQKEDDVEKFDVDVFVMGHDWEGEFDFLKDKCEVIYLKRTEGISTT
USA300_FPR3757 SIRYVDLVIPEKGWGQKEDDVEKFDVDVFVMGHDWEGEFDFLKDKCEVIYLKRTEGISTT
************************************************************
COL KIKQELYGKDAK
N315 KIKQELYGKDAK
NCTC8325 KIKQELYGKDAK
Newman KIKQELYGKDAK
USA300_FPR3757 KIKQELYGKDAK
************
- ↑ David S Badurina, Michela Zolli-Juran, Eric D Brown
CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi-Bi reaction mechanism with micromolar K(m) values.
Biochim Biophys Acta: 2003, 1646(1-2);196-206
[PubMed:12637027] [WorldCat.org] [DOI] (P p)Desiree H Fong, Veronica C-N Yim, Michael A D'Elia, Eric D Brown, Albert M Berghuis
Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism.
Biochim Biophys Acta: 2006, 1764(1);63-9
[PubMed:16344011] [WorldCat.org] [DOI] (P p)Ziliang Qian, Yanbin Yin, Yong Zhang, Lingyi Lu, Yixue Li, Ying Jiang
Genomic characterization of ribitol teichoic acid synthesis in Staphylococcus aureus: genes, genomic organization and gene duplication.
BMC Genomics: 2006, 7;74
[PubMed:16595020] [WorldCat.org] [DOI] (I e)