⊟Summary[edit | edit source]

pan ID^?: SAUPAN002520000
symbol^?: abcA
synonym:
description^?: ABC transporter ATP-binding protein
- ABC transporter ATP-binding protein
- ABC transporter ATP-binding protein/permease
- ATP-binding cassette transporter A
- multidrug ABC transporter ATP-binding protein, putative
- ABC superfamily ATP binding cassette transporter, ABC protein
- ABC transporter
- ABC transporter-like protein
- Lipid A export ATP-binding/permease MsbA
- Lipid A export ATP-binding/permease protein MsbA
- multidrug resistance ABC transporter ATP-binding/permease protein BmrA
- multidrug resistance ABC transporter ATP-binding and permease
- multidrug resistance ABC transporter ATP-binding and permease protein
strand^?: +
coordinates^?: 3032911..3034638
synteny block^?: BlockID0017560
occurrence^?: in 100% of 34 strains

abcA (msbA) : multidrug resistance and Lipid A export transporter ^[1]

⊟Orthologs[edit | edit source]

COL:

SACOL0700 (abcA)

N315:

NCTC8325:

Newman:

USA300_FPR3757:

04-02981:

SA2981_0619 (msbA)

08BA02176:

C248_0725

11819-97:

MS7_0694 (bmrA)

6850:

RSAU_000599

71193:

ST398NM01_0722

ECT-R 2:

ECTR2_595

ED133:

SAOV_0678 (abcA)

ED98:

SAAV_0606 (abcA)

HO 5096 0412:

SAEMRSA15_05690

JH1:

SaurJH1_0681

JH9:

SaurJH9_0666

JKD6008:

SAA6008_00660 (abcA)

JKD6159:

SAA6159_00598 (abcA)

JSNZ:

JSNZ_000610

LGA251:

SARLGA251_05770 (abcA)

M013:

M013TW_0631

MRSA252:

SAR0653

MSHR1132:

SAMSHR1132_05890

MSSA476:

SAS0609

Mu3:

SAHV_0640

Mu50:

SAV0643

MW2:

MW0605

RF122:

SAB0593

ST398:

SAPIG0722

T0131:

SAT0131_00713 (pcrB)

TCH60:

HMPREF0772_12544 (lmrA)

TW20:

SATW20_07180 (abcA)

USA300_TCH1516:

USA300HOU_0663

VC40:

SAVC_02850

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MKRENPLFFLFKKLSWPVGLIVAAITISSLGSLSGLLVPLFTGRIVDKFSVSHINWNLIA
N315            MKRENPLFFLFKKLSWPVGLIVAAITISSLGSLSGLLVPLFTGRIVDKFSVSHINWNLIA
NCTC8325        MKRENPLFFLFKKLSWPVGLIVAAITISSLGSLSGLLVPLFTGRIVDKFSVSHINWNLIA
Newman          MKRENPLFFLFKKLSWPVGLIVAAITISSLGSLSGLLVPLFTGRIVDKFSVSHINWNLIA
USA300_FPR3757  MKRENPLFFLFKKLSWPVGLIVAAITISSLGSLSGLLVPLFTGRIVDKFSVSHINWNLIA
                ************************************************************

COL             LFGGIFVINALLSGLGLYLLSKIGEKIIYAIRSVLWEHIIQLKMPFFDKNESGQLMSRLT
N315            LFGGIFVINALLSGLGLYLLSKIGEKIIYAIRSVLWEHIIQLKMPFFDKNESGQLMSRLT
NCTC8325        LFGGIFVINALLSGLGLYLLSKIGEKIIYAIRSVLWEHIIQLKMPFFDKNESGQLMSRLT
Newman          LFGGIFVINALLSGLGLYLLSKIGEKIIYAIRSVLWEHIIQLKMPFFDKNESGQLMSRLT
USA300_FPR3757  LFGGIFVINALLSGLGLYLLSKIGEKIIYAIRSVLWEHIIQLKMPFFDKNESGQLMSRLT
                ************************************************************

COL             DDTKVINEFISQKLPNLLPSIVTLVGSLIMLFILDWKMTLLTFITIPIFVLIMIPLGRIM
N315            DDTKVINEFISQKLPNLLPSIVTLVGSLIMLFILDWKMTLLTFITIPIFVLIMIPLGRIM
NCTC8325        DDTKVINEFISQKLPNLLPSIVTLVGSLIMLFILDWKMTLLTFITIPIFVLIMIPLGRIM
Newman          DDTKVINEFISQKLPNLLPSIVTLVGSLIMLFILDWKMTLLTFITIPIFVLIMIPLGRIM
USA300_FPR3757  DDTKVINEFISQKLPNLLPSIVTLVGSLIMLFILDWKMTLLTFITIPIFVLIMIPLGRIM
                ************************************************************

COL             QKISTSTQSEIANFSGLLGRVLTEMRLVKISNTERLELDNAHKNLNEIYKLGLKQAKIAA
N315            QKISTSTQSEIANFSGLLGRVLTEMRLVKISNTERLELDNAHKNLNEIYKLGLKQAKIAA
NCTC8325        QKISTSTQSEIANFSGLLGRVLTEMRLVKISNTERLELDNAHKNLNEIYKLGLKQAKIAA
Newman          QKISTSTQSEIANFSGLLGRVLTEMRLVKISNTERLELDNAHKNLNEIYKLGLKQAKIAA
USA300_FPR3757  QKISTSTQSEIANFSGLLGRVLTEMRLVKISNTERLELDNAHKNLNEIYKLGLKQAKIAA
                ************************************************************

COL             VVQPISGIVMLLTIAIILGFGALEIATGAITAGTLIAMIFYVIQLSMPLINLSTLVTDYK
N315            VVQPISGIVMLLTIAIILGFGALEIATGAITAGTLIAMIFYVIQLSMPLINLSTLVTDYK
NCTC8325        VVQPISGIVMLLTIAIILGFGALEIATGAITAGTLIAMIFYVIQLSMPLINLSTLVTDYK
Newman          VVQPISGIVMLLTIAIILGFGALEIATGAITAGTLIAMIFYVIQLSMPLINLSTLVTDYK
USA300_FPR3757  VVQPISGIVMLLTIAIILGFGALEIATGAITAGTLIAMIFYVIQLSMPLINLSTLVTDYK
                ************************************************************

COL             KAVGASSRIYEIMQEPIEPTEALEDSENVLIDDGVLSFEHVDFKYDVKKILDDVSFQIPQ
N315            KAVGASSRIYEIMQEPIEPTEALEDSENVLIDDGVLSFEHVDFKYDVKKILDDVSFQIPQ
NCTC8325        KAVGASSRIYEIMQEPIEPTEALEDSENVLIDDGVLSFEHVDFKYDVKKILDDVSFQIPQ
Newman          KAVGASSRIYEIMQEPIEPTEALEDSENVLIDDGVLSFEHVDFKYDVKKILDDVSFQIPQ
USA300_FPR3757  KAVGASSRIYEIMQEPIEPTEALEDSENVLIDDGVLSFEHVDFKYDVKKILDDVSFQIPQ
                ************************************************************

COL             GQVSAFVGPSGSGKSTIFNLIERMYEIESGDIKYGLESVYDIPLSKWRRKIGYVMQSNSM
N315            GQVSAFVGPSGSGKSTIFNLIERMYEIESGDIKYGLESVYDIPLSKWRRKIGYVMQSNSM
NCTC8325        GQVSAFVGPSGSGKSTIFNLIERMYEIESGDIKYGLESVYDIPLSKWRRKIGYVMQSNSM
Newman          GQVSAFVGPSGSGKSTIFNLIERMYEIESGDIKYGLESVYDIPLSKWRRKIGYVMQSNSM
USA300_FPR3757  GQVSAFVGPSGSGKSTIFNLIERMYEIESGDIKYGLESVYDIPLSKWRRKIGYVMQSNSM
                ************************************************************

COL             MSGTIRDNILYGINRHVSDEELINYAKLANCHDFIMQFDEGYDTLVGERGLKLSGGQRQR
N315            MSGTIRDNILYGINRHVSDEELINYAKLANCHDFIMQFDEGYDTLVGERGLKLSGGQRQR
NCTC8325        MSGTIRDNILYGINRHVSDEELINYAKLANCHDFIMQFDEGYDTLVGERGLKLSGGQRQR
Newman          MSGTIRDNILYGINRHVSDEELINYAKLANCHDFIMQFDEGYDTLVGERGLKLSGGQRQR
USA300_FPR3757  MSGTIRDNILYGINRHVSDEELINYAKLANCHDFIMQFDEGYDTLVGERGLKLSGGQRQR
                ************************************************************

COL             IDIARSFVKNPDILLLDEATANLDSESELKIQEALETLMEGRTTIVIAHRLSTIKKAGQI
N315            IDIARSFVKNPDILLLDEATANLDSESELKIQEALETLMEGRTTIVIAHRLSTIKKAGQI
NCTC8325        IDIARSFVKNPDILLLDEATANLDSESELKIQEALETLMEGRTTIVIAHRLSTIKKAGQI
Newman          IDIARSFVKNPDILLLDEATANLDSESELKIQEALETLMEGRTTIVIAHRLSTIKKAGQI
USA300_FPR3757  IDIARSFVKNPDILLLDEATANLDSESELKIQEALETLMEGRTTIVIAHRLSTIKKAGQI
                ************************************************************

COL             IFLDKGQVTGKGTHSELMASHAKYKNFVVSQKLTD
N315            IFLDKGQVTGKGTHSELMASHAKYKNFVVSQKLTD
NCTC8325        IFLDKGQVTGKGTHSELMASHAKYKNFVVSQKLTD
Newman          IFLDKGQVTGKGTHSELMASHAKYKNFVVSQKLTD
USA300_FPR3757  IFLDKGQVTGKGTHSELMASHAKYKNFVVSQKLTD
                ***********************************

↑ Hirono Yoshikai, Hayato Kizaki, Yuki Saito, Yosuke Omae, Kazuhisa Sekimizu, Chikara Kaito
Multidrug-Resistance Transporter AbcA Secretes Staphylococcus aureus Cytolytic Toxins.
J Infect Dis: 2016, 213(2);295-304
[PubMed:26160745] [WorldCat.org] [DOI] (I p)Rupak Doshi, Barbara Woebking, Hendrik W van Veen
Dissection of the conformational cycle of the multidrug/lipidA ABC exporter MsbA.
Proteins: 2010, 78(14);2867-72
[PubMed:20715055] [WorldCat.org] [DOI] (I p)Seth W Dickey, Dylan J Burgin, Steven Huang, David Maguire, Michael Otto
Two transporters cooperate to secrete amphipathic peptides from the cytoplasmic and membranous milieus.
Proc Natl Acad Sci U S A: 2023, 120(8);e2211689120
[PubMed:36787359] [WorldCat.org] [DOI] (I p)

[1] Hirono Yoshikai, Hayato Kizaki, Yuki Saito, Yosuke Omae, Kazuhisa Sekimizu, Chikara Kaito
Multidrug-Resistance Transporter AbcA Secretes Staphylococcus aureus Cytolytic Toxins.
J Infect Dis: 2016, 213(2);295-304
[PubMed:26160745] [WorldCat.org] [DOI] (I p)Rupak Doshi, Barbara Woebking, Hendrik W van Veen
Dissection of the conformational cycle of the multidrug/lipidA ABC exporter MsbA.
Proteins: 2010, 78(14);2867-72
[PubMed:20715055] [WorldCat.org] [DOI] (I p)Seth W Dickey, Dylan J Burgin, Steven Huang, David Maguire, Michael Otto
Two transporters cooperate to secrete amphipathic peptides from the cytoplasmic and membranous milieus.
Proc Natl Acad Sci U S A: 2023, 120(8);e2211689120
[PubMed:36787359] [WorldCat.org] [DOI] (I p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]