Jump to navigation
Jump to search
⊟Summary[edit | edit source]
- pan ID?: SAUPAN003032000
- symbol?: dltB
- synonym:
- description?: D-alanyl-lipoteichoic acid biosynthesis protein DltB
- D-alanyl-lipoteichoic acid biosynthesis protein DltB
- DltB protein
- D-alanine lipoteichoic acid and wall teichoic acid esterification protein
- D-alanine lipoteichoic acid and wall teichoic acid esterification protein DltB
- D-alanine transfer protein DltB
- DltB membrane protein
- PG:teichoic acid D-alanyltransferase DltB
- activated D-alanine transport protein
- D-alanine membrane transfer protein
- D-alanyl transfer protein DltB
- membrane bound O-acyl transferase, MBOAT family protein
- membrane bound O-acyl transferase MBOAT family protein
- protein dltB
- putative activated D-alanine transport protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3422629..3423843
- synteny block?: BlockID0021400
- occurrence?: in 100% of 33 strains
dltB: D-alanyl-carrier protein:acyl shuttle protein ligase and flippase [1]
DltB is a part of the D-alanylation pathway of extracellular lipoteichoic acid modifications
• In the LTA D-alanylation pathway, D-alanine is activated (adenylylated) by DltA and thioesterified onto the phosphopantetheinylated carrier protein DltC. DltB transfers the D-alanine from DltC to an active site tyrosine of the acyl shuttle microprotein DltX and flips it to the outer leaflet of the membrane. Once on the outer leaflet, DltD can transfer the D-alanine from D-alanyl-DltX it to the 2-OH of the extracellular poly-glycerophosphate LTA.
• Under high salt conditions, the alternate sigma factor SigB activates LTA glycosylation and represses LTA D-alanylation.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0888 (dltB)
08BA02176:
C248_0932 (dltB)
11819-97:
MS7_0888 (dltB)
6850:
RSAU_000810 (dltB)
71193:
ST398NM01_0916
ECT-R 2:
ECTR2_789
ED133:
SAOV_0879
ED98:
SAAV_0894 (dltB)
HO 5096 0412:
SAEMRSA15_07630 (dltB)
JH1:
SaurJH1_0952
JH9:
SaurJH9_0933
JKD6008:
SAA6008_00884 (dltB)
JKD6159:
SAA6159_00792 (dltB)
LGA251:
SARLGA251_08510 (dltB)
M013:
M013TW_0852
MRSA252:
SAR0895 (dltB)
MSHR1132:
SAMSHR1132_07850
MSSA476:
SAS0803
Mu3:
SAHV_0928 (dltB)
Mu50:
SAV0933 (dltB)
MW2:
MW0815 (dltB)
RF122:
SAB0799 (dltB)
ST398:
SAPIG0916
T0131:
SAT0131_00963
TCH60:
HMPREF0772_12314 (dltB)
TW20:
SATW20_09330 (dltB)
USA300_TCH1516:
USA300HOU_0894 (dltB)
VC40:
SAVC_03840
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MIPYGDFTFFLIALIALLPVIILGFLGKRSYIYNGVVTAFMIVLIFSSDKHNLFDQKYLS
N315 MIPYGDFTFFLIALIALLPVIILGFLGKRSYIYNGVVTAFMIVLIFSSDKHNLFDQKYLS
NCTC8325 MIPYGDFTFFLIALIALLPVIILGFLGKRSYIYNGVVTAFMIVLIFSSDKHNLFDQKYLS
Newman MIPYGDFTFFLIALIALLPVIILGFLGKRSYIYNGVVTAFMIVLIFSSDKHNLFDQKYLS
USA300_FPR3757 MIPYGDFTFFLIALIALLPVIILGFLGKRSYIYNGVVTAFMIVLIFSSDKHNLFDQKYLS
************************************************************
COL VQLISFIIYVVWQVLLIMFYYHSKPKNNSFSKFVTVMVLSILPLALVKVLQSTWLGGHQI
N315 VQLISFIIYVVWQVLLIMFYYHSKPKNNSFSKFVTVMVLSILPLALVKVLQSTWLGGHQI
NCTC8325 VQLISFIIYVVWQVLLIMFYYHSKPKNNSFSKFVTVMVLSILPLALVKVLQSTWLGGHQI
Newman VQLISFIIYVVWQVLLIMFYYHSKPKNNSFSKFVTVMVLSILPLALVKVLQSTWLGGHQI
USA300_FPR3757 VQLISFIIYVVWQVLLIMFYYHSKPKNNSFSKFVTVMVLSILPLALVKVLQSTWLGGHQI
************************************************************
COL HFHESKLIEFVGFLGISYVTFKSVQLIMEIRDGSIKEIKVWKLIQFISFFPTISSGPIDR
N315 HFHESKLIEFVGFLGISYVTFKSVQLIMEIRDGSIKEIKVWKLIQFISFFPTISSGPIDR
NCTC8325 HFHESKLIEFVGFLGISYVTFKSVQLIMEIRDGSIKEIKVWKLIQFISFFPTISSGPIDR
Newman HFHESKLIEFVGFLGISYVTFKSVQLIMEIRDGSIKEIKVWKLIQFISFFPTISSGPIDR
USA300_FPR3757 HFHESKLIEFVGFLGISYVTFKSVQLIMEIRDGSIKEIKVWKLIQFISFFPTISSGPIDR
************************************************************
COL YKRFVKDDKKVPTGNEYRELVLKAIHMIMLGFLYKYIVAYFINTYAIMPLQLDLHGFVNL
N315 YKRFVKDDKKVPTGNEYRELVLKAIHMIMLGFLYKYIVAYFINTYAIMPLQLDLHGFVNL
NCTC8325 YKRFVKDDKKVPTGNEYRELVLKAIHMIMLGFLYKYIVAYFINTYAIMPLQLDLHGFVNL
Newman YKRFVKDDKKVPTGNEYRELVLKAIHMIMLGFLYKYIVAYFINTYAIMPLQLDLHGFVNL
USA300_FPR3757 YKRFVKDDKKVPTGNEYRELVLKAIHMIMLGFLYKYIVAYFINTYAIMPLQLDLHGFVNL
************************************************************
COL WLYMYAYSLYLFFDFAGYSLFAIAFSYLFGIKTPPNFDKPFKAKNIKDFWNRWHMTLSFW
N315 WLYMYAYSLYLFFDFAGYSLFAIAFSYLFGIKTPPNFDKPFKAKNIKDFWNRWHMTLSFW
NCTC8325 WLYMYAYSLYLFFDFAGYSLFAIAFSYLFGIKTPPNFDKPFKAKNIKDFWNRWHMTLSFW
Newman WLYMYAYSLYLFFDFAGYSLFAIAFSYLFGIKTPPNFDKPFKAKNIKDFWNRWHMTLSFW
USA300_FPR3757 WLYMYAYSLYLFFDFAGYSLFAIAFSYLFGIKTPPNFDKPFKAKNIKDFWNRWHMTLSFW
************************************************************
COL FRDCIYMRSLFYMSRKKLLKSQFAMSNVAFLINFFIMGIWHGIEVYYIVYGLYHAALFIG
N315 FRDCIYMRSLFYMSRKKLLKSQFAMSNVAFLINFFIMGIWHGIEVYYIVYGLYHAALFIG
NCTC8325 FRDCIYMRSLFYMSRKKLLKSQFAMSNVAFLINFFIMGIWHGIEVYYIVYGLYHAALFIG
Newman FRDCIYMRSLFYMSRKKLLKSQFAMSNVAFLINFFIMGIWHGIEVYYIVYGLYHAALFIG
USA300_FPR3757 FRDCIYMRSLFYMSRKKLLKSQFAMSNVAFLINFFIMGIWHGIEVYYIVYGLYHAALFIG
************************************************************
COL YGYYERWRKKHPPRWQNGFTTALSIVITFHFVTFGFLIFSGKLI
N315 YGYYERWRKKHPPRWQNGFTTALSIVITFHFVTFGFLIFSGKLI
NCTC8325 YGYYERWRKKHPPRWQNGFTTALSIVITFHFVTFGFLIFSGKLI
Newman YGYYERWRKKHPPRWQNGFTTALSIVITFHFVTFGFLIFSGKLI
USA300_FPR3757 YGYYERWRKKHPPRWQNGFTTALSIVITFHFVTFGFLIFSGKLI
********************************************
- ↑ Christopher Weidenmaier, Andreas Peschel, Volkhard A J Kempf, Natalie Lucindo, Michael R Yeaman, Arnold S Bayer
DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model.
Infect Immun: 2005, 73(12);8033-8
[PubMed:16299297] [WorldCat.org] [DOI] (P p)Pingfeng Zhang, Zheng Liu
Structural insights into the transporting and catalyzing mechanism of DltB in LTA D-alanylation.
Nat Commun: 2024, 15(1);3404
[PubMed:38649359] [WorldCat.org] [DOI] (I e)