⊟Summary[edit | edit source]
- pan ID?: SAUPAN003033000
- symbol?: dltC
- synonym:
- description?: D-alanine--poly(phosphoribitol) ligase subunit 2
- D-alanine--poly(phosphoribitol) ligase subunit 2
- D-alanine--poly(phosphoribitol) ligase subunit 2 DltC
- D-alanine-activating enzyme/D-alanine-D-alanyl, dltC protein
- D-alanine--D-alanine ligase
- D-alanine--poly(phosphoribitol) ligase, subunit 2
- D-alanyl carrier protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3423861..3424097
- synteny block?: BlockID0021410
- occurrence?: in 100% of 33 strains
dltC: D-alanine peptidyl carrier protein [1]
DltC is a part of the D-alanylation pathway of extracellular lipoteichoic acid modifications
• In the LTA D-alanylation pathway, D-alanine is activated (adenylylated) by DltA and thioesterified onto the phosphopantetheinylated carrier protein DltC. DltB transfers the D-alanine from DltC to an active site tyrosine of the acyl shuttle microprotein DltX and flips it to the outer leaflet of the membrane. Once on the outer leaflet, DltD can transfer the D-alanine from D-alanyl-DltX it to the 2-OH of the extracellular poly-glycerophosphate LTA.
• Under high salt conditions, the alternate sigma factor SigB activates LTA glycosylation and represses LTA D-alanylation.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MEFREQVLNLLAEVAENDIVKENPDVEIFEEGIIDSFQTVGLLLEIQNKLDIEVSIMDFD
N315 MEFREQVLNLLAEVAENDIVKENPDVEIFEEGIIDSFQTVGLLLEIQNKLDIEVSIMDFD
NCTC8325 MEFREQVLNLLAEVAENDIVKENPDVEIFEEGIIDSFQTVGLLLEIQNKLDIEVSIMDFD
Newman MEFREQVLNLLAEVAENDIVKENPDVEIFEEGIIDSFQTVGLLLEIQNKLDIEVSIMDFD
USA300_FPR3757 MEFREQVLNLLAEVAENDIVKENPDVEIFEEGIIDSFQTVGLLLEIQNKLDIEVSIMDFD
************************************************************
COL RDEWATPNKIVEALEELR
N315 RDEWATPNKIVEALEELR
NCTC8325 RDEWATPNKIVEALEELR
Newman RDEWATPNKIVEALEELR
USA300_FPR3757 RDEWATPNKIVEALEELR
******************
- ↑ Christopher Weidenmaier, Andreas Peschel, Volkhard A J Kempf, Natalie Lucindo, Michael R Yeaman, Arnold S Bayer
DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model.
Infect Immun: 2005, 73(12);8033-8
[PubMed:16299297] [WorldCat.org] [DOI] (P p)