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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003034000
- symbol?: dltD
- synonym:
- description?: D-alanyl-lipoteichoic acid biosynthesis protein DltD
- D-alanyl-lipoteichoic acid biosynthesis protein DltD
- D-alanine-activating DltD protein
- D-alanine-activating enzyme/D-alanine-D-alanyl, dltD protein
- DltD protein
- extramembranal protein
- poly D-alanine transfer protein
- poly D-alanine transfer protein DltD
- D-alanine lipoteichoic acid and wall teichoic acid esterification secreted protein
- DltD, central domain protein
- dltD C-terminal region family protein
- DltD domain-containing protein
- lipoteichoic acid biosynthesis protein
- poly #glycerophosphate chain D-alanine transfer protein
- poly (glycerophosphate chain) D-alanine transfer protein
- Poly(glycerophosphate chain) D-alanine transfer protein DltD
- poly D-alanine transfer protein (glycerophosphate chain)
- protein dltD
- putative lipoteichoic acid biosynthesis protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3424094..3425269
- synteny block?: BlockID0021420
- occurrence?: in 100% of 33 strains
dltD: D-alanyl-acyl shuttle protein:lipoteichoic acid ligase [1]
DltD is a part of the D-alanylation pathway of extracellular lipoteichoic acid modifications
• In the LTA D-alanylation pathway, D-alanine is activated (adenylylated) by DltA and thioesterified onto the phosphopantetheinylated carrier protein DltC. DltB transfers the D-alanine from DltC to an active site tyrosine of the acyl shuttle microprotein DltX and flips it to the outer leaflet of the membrane. Once on the outer leaflet, DltD can transfer the D-alanine from D-alanyl-DltX it to the 2-OH of the extracellular poly-glycerophosphate LTA.
• Under high salt conditions, the alternate sigma factor SigB activates LTA glycosylation and represses LTA D-alanylation.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0890 (dltD)
08BA02176:
C248_0934 (dltD)
11819-97:
MS7_0890 (dltD)
6850:
RSAU_000812 (dltD)
71193:
ST398NM01_0918
ECT-R 2:
ECTR2_791
ED133:
SAOV_0881
ED98:
SAAV_0896 (dltD)
HO 5096 0412:
SAEMRSA15_07650 (dltD)
JH1:
SaurJH1_0954
JH9:
SaurJH9_0935
JKD6008:
SAA6008_00886 (dltD)
JKD6159:
SAA6159_00794 (dltD)
LGA251:
SARLGA251_08530 (dltD)
M013:
M013TW_0854
MRSA252:
SAR0897 (dltD)
MSHR1132:
SAMSHR1132_07870
MSSA476:
SAS0805
Mu3:
SAHV_0930 (dltD)
Mu50:
SAV0935 (dltD)
MW2:
MW0817 (dltD)
RF122:
SAB0801 (dltD)
ST398:
SAPIG0918
T0131:
SAT0131_00965 (kdpC)
TCH60:
HMPREF0772_12312 (dltD)
TW20:
SATW20_09350 (dltD)
USA300_TCH1516:
USA300HOU_0896 (dltD)
VC40:
SAVC_03850
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKLKPFLPILISGAVFIVFLLLPASWFTGLVNEKTVEDNRTSLTDQVLKGTLIQDKLYES
N315 MKLKPFLPILISGAVFIVFLLLPASWFTGLVNEKTVEDNRTSLTDQVLKGTLIQDKLYES
NCTC8325 MKLKPFLPILISGAVFIVFLLLPASWFTGLVNEKTVEDNRTSLTDQVLKGTLIQDKLYES
Newman MKLKPFLPILISGAVFIVFLLLPASWFTGLVNEKTVEDNRTSLTDQVLKGTLIQDKLYES
USA300_FPR3757 MKLKPFLPILISGAVFIVFLLLPASWFTGLVNEKTVEDNRTSLTDQVLKGTLIQDKLYES
************************************************************
COL NKYYPIYGSSELGKDDPFNPAIALNKHNANKKAFLLGAGGSTDLINAIELASQYDKLKGK
N315 NKYYPIYGSSELGKDDPFNPAIALNKHNANKKAFLLGAGGSTDLINAVELASQYDKLKGK
NCTC8325 NKYYPIYGSSELGKDDPFNPAIALNKHNANKKAFLLGAGGSTDLINAVELASQYDKLKGK
Newman NKYYPIYGSSELGKDDPFNPAIALNKHNANKKAFLLGAGGSTDLINAIELASQYDKLKGK
USA300_FPR3757 NKYYPIYGSSELGKDDPFNPAIALNKHNANKKAFLLGAGGSTDLINAVELASQYDKLKGK
***********************************************:************
COL KLTFIISPQWFTNHGLTNQNFDARMSQTQINQMFQQKNMSTELKRRYAQRLLQFPHVHNK
N315 KLTFIISPQWFTNHGLTNQNFDARMSQTQINQMFQQKNMSTELKRRYAQRLLQFPHVHNK
NCTC8325 KLTFIISPQWFTNHGLTNQNFDARMSQTQINQMFQQKNMSTELKRRYAQRLLQFPHVHNK
Newman KLTFIISPQWFTNHGLTNQNFDARMSQTQINQMFQQKNMSTELKRRYAQRLLQFPHVHNK
USA300_FPR3757 KLTFIISPQWFTNHGLTNQNFDARMSQTQINQMFQQKNMSTELKRRYAQRLLQFPHVHNK
************************************************************
COL EYLKSYAKNPKETKDSYISGFKENQLIKIEAIKSLFAMDKSPLEHVKPATKPDASWDEMK
N315 EYLKSYAKNPKETKDSYISGFKENQLIKIEAIKSLFAMDKSPLEHVKPATKPDASWDEMK
NCTC8325 EYLKSYAKNPKETKDSYISGFKENQLIKIEAIKSLFAMDKSPLEHVKPATKPDASWDEMK
Newman EYLKSYAKNPKETKDSYISGFKENQLIKIEAIKSLFAMDKSPLEHVKPATKPDASWDEMK
USA300_FPR3757 EYLKSYAKNPKETKDSYISGFKENQLIKIEAIKSLFAMDKSPLEHVKPATKPDASWDEMK
************************************************************
COL QKAVEIGKADTTSNKFGIRDQYWKLIQESKRKVRRDYEFNVNSPEFQDLELLVKTMRAAG
N315 QKAVEIGKADTTSNKFGIRDQYWILIQESKRKVRRDYEFNVNSPEFQDLELLVKTMRAAG
NCTC8325 QKAVEIGKADTTSNKFGIRDQYWKLIQESKRKVRRDYEFNVNSPEFQDLELLVKTMRAAG
Newman QKAVEIGKADTTSNKFGIRDQYWKLIQESKRKVRRDYEFNVNSPEFQDLELLVKTMRAAG
USA300_FPR3757 QKAVEIGKADTTSNKFGIRDQYWKLIQESKRKVRRDYEFNVNSPEFQDLELLVKTMRAAG
*********************** ************************************
COL ADVQYVSIPSNGVWYDHIGIDKERRQAVYKKIHSTVVDNGGKIYDMTDKDYEKYVISDAV
N315 ADVQYVSIPSNGVWYDHIGIDKERRQAVYKKIHSTVVDNGGKIYDMTDKDYEKYVISDAV
NCTC8325 ADVQYVSIPSNGVWYDHIGIDKERRQAVYKKIHSTVVDNGGKIYDMTDKDYEKYVISDAV
Newman ADVQYVSIPSNGVWYDHIGIDKERRQAVYKKIHSTVVDNGGKIYDMTDKDYEKYVISDAV
USA300_FPR3757 ADVQYVSIPSNGVWYDHIGIDKERRQAVYKKIHSTVVDNGGKIYDMTDKEYEKYVISDAV
*************************************************:**********
COL HIGWKGWVYMDEQIAKHMKGEPQPEVDKPKN
N315 HIGWKGWVYMDEQIAKHMKGEPQPEVDKPKN
NCTC8325 HIGWKGWVYMDEQIAKHMKGEPQPEVDKPKN
Newman HIGWKGWVYMDEQIAKHMKGEPQPEVDKPKN
USA300_FPR3757 HIGWKGWVYMDEQIAKHMKGEPQPEVDKPKN
*******************************
- ↑ Christopher Weidenmaier, Andreas Peschel, Volkhard A J Kempf, Natalie Lucindo, Michael R Yeaman, Arnold S Bayer
DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model.
Infect Immun: 2005, 73(12);8033-8
[PubMed:16299297] [WorldCat.org] [DOI] (P p)B McKay Wood, John P Santa Maria, Leigh M Matano, Christopher R Vickery, Suzanne Walker
A partial reconstitution implicates DltD in catalyzing lipoteichoic acid d-alanylation.
J Biol Chem: 2018, 293(46);17985-17996
[PubMed:30237166] [WorldCat.org] [DOI] (I p)