⊟Summary[edit | edit source]

pan ID^?: SAUPAN003053000
symbol^?: mnhA1
synonym:
description^?: Na+/H+ antiporter subunit A
- Na+/H+ antiporter subunit A
- monovalent cation/H+ antiporter subunit A
- CPA3 family monovalent cation (K+ or Na+):proton (H+) antiporter-3 MnhA subunit
- monovalent cation:proton antiporter family protein
- monovalent cation antiporter-3 subunit A, MnhA
- Na(+)/H(+) antiporter subunit A (Multiple resistance and pHhomeostasis protein A) (Mrp complex subunit A)
- Na(+)/H(+) antiporter subunit A1
- Na(+) H(+) antiporter subunit A
- Na+/H+ antiporter subunit
- ShaA
strand^?: -
coordinates^?: 3441665..3444070
synteny block^?: BlockID0021610
occurrence^?: in 100% of 33 strains

mnhA1 (snoA): sodium/proton antiporter subunit A ^[1]

• previously annotated as Staphylococcal NADH:ubiquinone oxidoreductase ortholog as it could establish an ion gradient

⊟Orthologs[edit | edit source]

COL:

SACOL0955 (mnhA)

N315:

SA0813 (mnhA)

NCTC8325:

SAOUHSC_00889

Newman:

NWMN_0822 (mnhA)

USA300_FPR3757:

SAUSA300_0855 (mnhA)

04-02981:

SA2981_0907 (mnhA)

08BA02176:

C248_0951 (mnhA)

11819-97:

MS7_0907 (mnhA1)

6850:

RSAU_000829 (mnhA2)

71193:

ST398NM01_0935

ECT-R 2:

ECTR2_808 (CPA3)

ED133:

SAOV_0898c

ED98:

SAAV_0913 (mnhA)

HO 5096 0412:

SAEMRSA15_07820 (mnhA)

JH1:

SaurJH1_0971

JH9:

SaurJH9_0952

JKD6008:

SAA6008_00905 (mnhA)

JKD6159:

SAA6159_00811 (mnhA)

LGA251:

SARLGA251_08700 (mnhA)

M013:

M013TW_0871

MRSA252:

SAR0914 (mnhA)

MSHR1132:

SAMSHR1132_08040

MSSA476:

SAS0822

Mu3:

SAHV_0947 (mnhA)

Mu50:

SAV0952 (mnhA)

MW2:

MW0834 (mnhA)

RF122:

SAB0819c (mnhA)

ST398:

SAPIG0935

T0131:

SAT0131_00984

TCH60:

HMPREF0772_12295 (mnhA)

TW20:

SATW20_09520 (mnhA)

USA300_TCH1516:

USA300HOU_0912 (mnhA2)

VC40:

SAVC_03935

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMK
N315            MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMK
NCTC8325        MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMK
Newman          MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMK
USA300_FPR3757  MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMK
                ************************************************************

COL             TLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMG
N315            TLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMG
NCTC8325        TLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMG
Newman          TLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMG
USA300_FPR3757  TLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMG
                ************************************************************

COL             AMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGI
N315            AMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGI
NCTC8325        AMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGI
Newman          AMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGI
USA300_FPR3757  AMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGI
                ************************************************************

COL             ILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPT
N315            ILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPT
NCTC8325        ILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPT
Newman          ILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPT
USA300_FPR3757  ILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPT
                ************************************************************

COL             PVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGI
N315            PVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGI
NCTC8325        PVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGI
Newman          PVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGI
USA300_FPR3757  PVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGI
                ************************************************************

COL             LAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGA
N315            LAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGA
NCTC8325        LAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGA
Newman          LAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGA
USA300_FPR3757  LAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGA
                ************************************************************

COL             VDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQAN
N315            VDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQAN
NCTC8325        VDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQAN
Newman          VDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQAN
USA300_FPR3757  VDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQAN
                ************************************************************

COL             LFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAI
N315            LFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAI
NCTC8325        LFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAI
Newman          LFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAI
USA300_FPR3757  LFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAI
                ************************************************************

COL             LATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILL
N315            LATLVIVLGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILL
NCTC8325        LATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILL
Newman          LATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILL
USA300_FPR3757  LATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILL
                *******:****************************************************

COL             IVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALIL
N315            IVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALIL
NCTC8325        IVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALIL
Newman          IVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALIL
USA300_FPR3757  IVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALIL
                ************************************************************

COL             LTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVS
N315            LTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVS
NCTC8325        LTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVS
Newman          LTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVS
USA300_FPR3757  LTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVS
                ************************************************************

COL             VLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSV
N315            VLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSV
NCTC8325        VLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSV
Newman          VLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSV
USA300_FPR3757  VLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSV
                ************************************************************

COL             IIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAV
N315            IIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAV
NCTC8325        IIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAV
Newman          IIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAV
USA300_FPR3757  IIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAV
                ************************************************************

COL             YTMIKLRKKRQTQGNEVKNHE
N315            YTMIKLRKKRQTQGNEVKNHE
NCTC8325        YTMIKLRKKRQTQGNEVKNHE
Newman          YTMIKLRKKRQTQGNEVKNHE
USA300_FPR3757  YTMIKLRKKRQTQGNEVKNHE
                *********************

↑ Manisha Vaish, Alexa Price-Whelan, Tamara Reyes-Robles, Jun Liu, Amyeo Jereen, Stephanie Christie, Francis Alonzo, Meredith A Benson, Victor J Torres, Terry A Krulwich
Roles of Staphylococcus aureus Mnh1 and Mnh2 Antiporters in Salt Tolerance, Alkali Tolerance, and Pathogenesis.
J Bacteriol: 2018, 200(5);
[PubMed:29263099] [WorldCat.org] [DOI] (I e)Masahiro Ito, Masato Morino, Terry A Krulwich
Mrp Antiporters Have Important Roles in Diverse Bacteria and Archaea.
Front Microbiol: 2017, 8;2325
[PubMed:29218041] [WorldCat.org] [DOI] (P e)

[1] Manisha Vaish, Alexa Price-Whelan, Tamara Reyes-Robles, Jun Liu, Amyeo Jereen, Stephanie Christie, Francis Alonzo, Meredith A Benson, Victor J Torres, Terry A Krulwich
Roles of Staphylococcus aureus Mnh1 and Mnh2 Antiporters in Salt Tolerance, Alkali Tolerance, and Pathogenesis.
J Bacteriol: 2018, 200(5);
[PubMed:29263099] [WorldCat.org] [DOI] (I e)Masahiro Ito, Masato Morino, Terry A Krulwich
Mrp Antiporters Have Important Roles in Diverse Bacteria and Archaea.
Front Microbiol: 2017, 8;2325
[PubMed:29218041] [WorldCat.org] [DOI] (P e)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]