⊟Summary[edit | edit source]

pan ID^?: SAUPAN003128000
symbol^?: fabF
synonym:
description^?: beta-ketoacyl-[acyl-carrier-protein] synthase II
- beta-ketoacyl-[acyl-carrier-protein] synthase II
- 3-oxoacyl-(acyl-carrier-protein) synthase II
- 3-oxoacyl-ACP synthase
- 3-oxoacyl-[acyl-carrier-protein] synthase
- 3-oxoacyl- synthase
- beta-ketoacyl-ACP synthase II
- 3-oxoacyl-[acyl-carrier-protein] synthase, KASII
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- 3-oxoacyl-ACP synthase II
- 3-oxoacyl- synthase ,KASII
- beta-ketoacyl-acyl-carrier-protein synthase II
- Beta-ketoacyl synthase-like protein
strand^?: +
coordinates^?: 3511111..3512355
synteny block^?: BlockID0022200
occurrence^?: in 100% of 33 strains

fabF: beta-ketoacyl-(acyl-carrier-protein) synthase II ^[1]

A crystal structure is available: 2GQD

⊟Orthologs[edit | edit source]

COL:

SACOL0988 (fabF)

N315:

SA0843 (fab)

NCTC8325:

SAOUHSC_00921

Newman:

NWMN_0854

USA300_FPR3757:

SAUSA300_0886 (fabF)

04-02981:

SA2981_0939

08BA02176:

C248_1007 (fabF)

11819-97:

MS7_0939 (fabF)

6850:

RSAU_000859 (fabF)

71193:

ST398NM01_0980

ECT-R 2:

ECTR2_839 (fabF)

ED133:

SAOV_0930

ED98:

SAAV_0945 (fabF)

HO 5096 0412:

SAEMRSA15_08130 (fabF)

JH1:

SaurJH1_1002

JH9:

SaurJH9_0983

JKD6008:

SAA6008_00937 (fabB)

JKD6159:

SAA6159_00840 (fabB)

LGA251:

SARLGA251_09010 (fabF)

M013:

M013TW_0906

MRSA252:

SAR0947 (fabF)

MSHR1132:

SAMSHR1132_08320

MSSA476:

SAS0854

Mu3:

SAHV_0979

Mu50:

SAV0984

MW2:

MW0866 (fab)

RF122:

SAB0849 (fabF)

ST398:

SAPIG0980 (fabF)

T0131:

SAT0131_01017 (atpB)

TCH60:

HMPREF0772_12261 (fabF)

TW20:

SATW20_09830 (fabF)

USA300_TCH1516:

USA300HOU_0942 (fabH2)

VC40:

SAVC_04090

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MSQNKRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNI
N315            MSQNKRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNI
NCTC8325        MSQNKRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNI
Newman          MSQNKRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNI
USA300_FPR3757  MSQNKRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNI
                ************************************************************

COL             EDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAH
N315            EDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINDNTADRIGVWIGSGIGGMETFEIAH
NCTC8325        EDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAH
Newman          EDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAH
USA300_FPR3757  EDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAH
                ***********************************:************************

COL             KQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQ
N315            KQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQ
NCTC8325        KQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQ
Newman          KQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQ
USA300_FPR3757  KQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQ
                ************************************************************

COL             RGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILV
N315            RGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILV
NCTC8325        RGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILV
Newman          RGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILV
USA300_FPR3757  RGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILV
                ************************************************************

COL             IESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQY
N315            IESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQY
NCTC8325        IESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQY
Newman          IESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQY
USA300_FPR3757  IESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQY
                ************************************************************

COL             LNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKD
N315            LNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKD
NCTC8325        LNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKD
Newman          LNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKD
USA300_FPR3757  LNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVNSTKSMTGHLLGATGGIEAIFSALSIKD
                ********************************.***************************

COL             SKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFKKFEA
N315            SKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFKKFEA
NCTC8325        SKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFKKFEA
Newman          SKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFKKFEA
USA300_FPR3757  SKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFKKFEA
                ******************************************************

↑ Joshua B Parsons, Jiangwei Yao, Matthew W Frank, Charles O Rock
FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.
Antimicrob Agents Chemother: 2015, 59(2);849-58
[PubMed:25403676] [WorldCat.org] [DOI] (I p)

[1] Joshua B Parsons, Jiangwei Yao, Matthew W Frank, Charles O Rock
FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.
Antimicrob Agents Chemother: 2015, 59(2);849-58
[PubMed:25403676] [WorldCat.org] [DOI] (I p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]