⊟Summary[edit | edit source]

pan ID^?: SAUPAN003353000
symbol^?: —
synonym:
description^?: nucleotidyltransferase
- nucleotidyltransferase
- putative DUF795-containing protein
strand^?: -
coordinates^?: 3718793..3719932
synteny block^?: BlockID0024370
occurrence^?: in 100% of 33 strains

tmcAL (ylbM) : tRNA cytidine(34) N(4)-acetyltransferase ^[1]

Several transfer RNAs require modifications to provide maximal fidelity during protein synthesis. TmcAL is an acetyltransferase specific for cytidines at tRNA position 34 generating 4-acetylcytidine ("ac⁴C" or "M"). This modification is only required for the unique tRNAM_CAU elongator tRNA, reducing inappropriate methionine formylation and inappropriate isoleucyl charging.

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

04-02981:

SA2981_1082

08BA02176:

C248_1152

11819-97:

MS7_1082

6850:

RSAU_001010

71193:

ST398NM01_1122

ECT-R 2:

ECTR2_980

ED133:

SAOV_1067c

ED98:

SAAV_1092

HO 5096 0412:

SAEMRSA15_09550

JH1:

SaurJH1_1207

JH9:

SaurJH9_1185

JKD6008:

SAA6008_01080

JKD6159:

SAA6159_00980

LGA251:

SARLGA251_10380

M013:

M013TW_1057

MRSA252:

SAR1099

MSHR1132:

SAMSHR1132_09720

MSSA476:

SAS1060

Mu3:

SAHV_1117

Mu50:

SAV1126

MW2:

MW1008

RF122:

SAB0990c

ST398:

SAPIG1122

T0131:

SAT0131_01164

TCH60:

HMPREF0772_12107

TW20:

SATW20_11200

USA300_TCH1516:

USA300HOU_1063

VC40:

SAVC_04790

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MKSVGLITEYNPFHNGHQYHINQSKKLTNADVTIAIMSGNFVMRGEPAIYNKFTRAKMAL
N315            MKSVGLITEYNPFHNGHQYHINQSKKLTNADVTIAIMSGNFVMRGEPAIYNKFTRAKMAL
NCTC8325        MKSVGLITEYNPFHNGHQYHINQSKKLTNADVTIAIMSGNFVMRGEPAIYNKFTRAKMAL
Newman          MKSVGLITEYNPFHNGHQYHINQSKKLTNADVTIAIMSGNFVMRGEPAIYNKFTRAKMAL
USA300_FPR3757  MKSVGLITEYNPFHNGHQYHINQSKKLTNADVTIAIMSGNFVMRGEPAIYNKFTRAKMAL
                ************************************************************

COL             STADLVIELPATASLSSGDHFAELAVKVADYMSVDTIAFGSENNDIKTLKQLAHSINEIE
N315            STADLVIELPATASLSSGDHFAELAVKVADYMSVDTIAFGSENNDIKTLKQLAHSINEIE
NCTC8325        STADLVIELPATASLSSGDHFAELAVKVADYMSVDTIAFGSENNDIKTLKQLAHSINEIE
Newman          STADLVIELPATASLSSGDHFAELAVKVADYMSVDTIAFGSENNDIKTLKQLAHSINEIE
USA300_FPR3757  STADLVIELPATASLSSGDHFAELAVKVADYMSVDTIAFGSENNDIKTLKQLAHSINEIE
                ************************************************************

COL             QSESFSQKVKEGKSYPRIISELLEHHEALASPNNILGISYLKAIAKNAKNINAISIKREN
N315            QSESFSQKVKEGKSYPRIISELLEHHEALASPNNILGISYLKAIAKNAKNINAISIKREN
NCTC8325        QSESFSQKVKEGKSYPRIISELLEHHEALASPNNILGISYLKAIAKNAKNINAISIKREN
Newman          QSESFSQKVKEGKSYPRIISELLEHHEALASPNNILGISYLKAIAKNAKNINAISIKREN
USA300_FPR3757  QSESFSQKVKEGKSYPRIISELLEHHEALASPNNILGISYLKAIAKNAKNINAISIKREN
                ************************************************************

COL             AQHHDSLIQHHQFASGTSIRTSIISQDDHWHHVVPKDIQHLYVTPHITLNQIFPYLKYQI
N315            AQHHDSLIQHHQFASGTSIRTSIISQDDHWHHVVPKDIQHLYVTPHITLNQIFPYLKYQI
NCTC8325        AQHHDSLIQHHQFASGTSIRTSIISQDDHWHHVVPKDIQHLYVTPHITLNQIFPYLKYQI
Newman          AQHHDSLIQHHQFASGTSIRTSIISQDDHWHHVVPKDIQHLYVTPHITLNQIFPYLKYQI
USA300_FPR3757  AQHHDSLIQHHQFASGTSIRTSIISQDDHWHHVVPKDIQHLYVTPHITLNQIFPYLKYQI
                ************************************************************

COL             IAMTTDSLKNIYTVTEGFENRLKSNIYEATDFHHFVKLLKTKRYTYTHIQRLLMNVLLNI
N315            IAMTTDSLKNIYTVTEGFENRLKSNIYEATDFHHFVKLLKTKRYTYTHIQRLLMNVLLNI
NCTC8325        IAMTTDSLKNIYTVTEGFENRLKSNIYEATDFHHFVKLLKTKRYTYTHIQRLLMNVLLNI
Newman          IAMTTDSLKNIYTVTEGFENRLKSNIYEATDFHHFVKLLKTKRYTYTHIQRLLMNVLLNI
USA300_FPR3757  IAMTTDSLKNIYTVTEGFENRLKSNIYEATDFHHFVKLLKTKRYTYTHIQRLLMNVLLNI
                ************************************************************

COL             KPTDVTSNIHAVKVLAMNDRGRQYLKHLKTAFPERQYITNINKSNAHYFTNEIKATHIYN
N315            KPTDVTSNIHAVKVLAMNDRGRQYLKHLKTAFPERQYITNINKSNAHYFTNEIKATHIYN
NCTC8325        KPTDVTSNIHAVKVLAMNDRGRQYLKHLKTAFPERQYITNINKSNAHYFTNEIKATHIYN
Newman          KPTDVTSNIHAVKVLAMNDRGRQYLKHLKTAFPERQYITNINKSNAHYFTNEIKATHIYN
USA300_FPR3757  KPTDVTSNIHAVKVLAMNDRGRQYLKHLKTAFPERQYITNINKSNAHYFTNEIKATHIYN
                ************************************************************

COL             AISGQQQTDFNTPVIQQYR
N315            AISGQQQTDFNTPVIQQYR
NCTC8325        AISGQQQTDFNTPVIQQYR
Newman          AISGQQQTDFNTPVIQQYR
USA300_FPR3757  AISGQQQTDFNTPVIQQYR
                *******************

↑ Takaaki Taniguchi, Kenjyo Miyauchi, Yuriko Sakaguchi, Seisuke Yamashita, Akiko Soma, Kozo Tomita, Tsutomu Suzuki
Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis.
Nat Chem Biol: 2018, 14(11);1010-1020
[PubMed:30150682] [WorldCat.org] [DOI] (I p)Laura Antoine, Philippe Wolff, Eric Westhof, Pascale Romby, Stefano Marzi
Mapping post-transcriptional modifications in Staphylococcus aureus tRNAs by nanoLC/MSMS.
Biochimie: 2019, 164;60-69
[PubMed:31295507] [WorldCat.org] [DOI] (I p)

[1] Takaaki Taniguchi, Kenjyo Miyauchi, Yuriko Sakaguchi, Seisuke Yamashita, Akiko Soma, Kozo Tomita, Tsutomu Suzuki
Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis.
Nat Chem Biol: 2018, 14(11);1010-1020
[PubMed:30150682] [WorldCat.org] [DOI] (I p)Laura Antoine, Philippe Wolff, Eric Westhof, Pascale Romby, Stefano Marzi
Mapping post-transcriptional modifications in Staphylococcus aureus tRNAs by nanoLC/MSMS.
Biochimie: 2019, 164;60-69
[PubMed:31295507] [WorldCat.org] [DOI] (I p)

[1]

Navigation menu

Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Search

Navigation menu

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]