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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN004084000
  • symbol?:
  • synonym:
  • description?: IS30 family transposase

      descriptions from strain specific annotations:

    • IS30 family transposase
    • pseudogene
  • strand?: -
  • coordinates?: 4364054..4368893
  • synteny block?: BlockID0031160
  • occurrence?: in 9% of 34 strains

tnpSau5 : ICE6013 insertion sequence Sau5 family transposase [1] [1]

All microbial genomes, including Staphylococci, contain mobile genetic elements integrated into their chromosomes that can mediate horizontal gene transfer. Sau5 family transposases are similar to the insertion sequence 30 family of mobile genetic elements flanked by inverted repeat sequences: IRL: CAACTCCCTATACGCTTTAGCGRTGGTATYGGGAGTTGATGAACATATAT and IRR: GATRAACCTATATTAATTGACGGGTTCGTGCCTCACACAGTCATTTAATA. It is characterized by ribosomal slippage at the recoding motif: AGTATCGGCTC AAAAAG TATAATAATCGT resulting in a 339 amino acid product across two distinct reading frames. ISSau5 is also the transposase responsible for mobilizing integrative chromosomal element 6013 (ICE6013).

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    08BA02176:
    11819-97:
    6850:
    71193:
    ECT-R 2:
    ED133:
    ED98:
    HO 5096 0412:
    JH1:
    JH9:
    JKD6008:
    JKD6159:
    JSNZ:
    LGA251:
    M013:
    MRSA252:
    MSHR1132:
    MSSA476:
    Mu3:
    Mu50:
    MW2:
    RF122:
    ST398:
    T0131:
    TCH60:
    TW20:
    USA300_TCH1516:
    USA300HOU_0625
    VC40:

Genome Viewer[edit | edit source]

COL
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:

  1. Zita Nagy, Mónika Szabó, Michael Chandler, Ferenc Olasz
    Analysis of the N-terminal DNA binding domain of the IS30 transposase.
    Mol Microbiol: 2004, 54(2);478-88
    [PubMed:15469518] [WorldCat.org] [DOI] (P p)
    Emily A Sansevere, Xiao Luo, Joo Youn Park, Sunghyun Yoon, Keun Seok Seo, D Ashley Robinson
    Transposase-Mediated Excision, Conjugative Transfer, and Diversity of ICE6013 Elements in Staphylococcus aureus.
    J Bacteriol: 2017, 199(8);
    [PubMed:28138100] [WorldCat.org] [DOI] (I e)