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Summary[edit | edit source]

  • pan ID?: SAUPAN004235000
  • symbol?: aspS
  • synonym:
  • description?: aspartyl-tRNA synthetase

      descriptions from strain specific annotations:

    • aspartyl-tRNA synthetase
    • aspartate--tRNA ligase
  • strand?: -
  • coordinates?: 4479416..4481182
  • synteny block?: BlockID0032630
  • occurrence?: in 100% of 33 strains

aspS (aspRS) aspartyl-/asparaginyl-tRNA synthetase [1]

Orthologs[edit | edit source]

    COL:
    SACOL1685 (aspS)
    N315:
    SA1456 (aspS)
    NCTC8325:
    Newman:
    NWMN_1532 (aspS)
    USA300_FPR3757:
    04-02981:
    SA2981_1588 (aspS)
    08BA02176:
    C248_1673 (aspS)
    11819-97:
    MS7_1645 (aspS)
    6850:
    RSAU_001491 (aspS)
    71193:
    ST398NM01_1693
    ECT-R 2:
    ECTR2_1478 (aspS)
    ED133:
    SAOV_1627 (aspS)
    ED98:
    SAAV_1623 (aspS)
    HO 5096 0412:
    SAEMRSA15_15470 (aspS)
    JH1:
    SaurJH1_1720 (aspS)
    JH9:
    SaurJH9_1687 (aspS)
    JKD6008:
    SAA6008_01599 (aspS)
    JKD6159:
    SAA6159_01562 (aspS)
    LGA251:
    SARLGA251_15320 (aspS)
    M013:
    M013TW_1650
    MRSA252:
    SAR1710 (aspS)
    MSHR1132:
    SAMSHR1132_14660
    MSSA476:
    SAS1566 (aspS)
    Mu3:
    SAHV_1617 (aspS)
    Mu50:
    SAV1630 (aspS)
    MW2:
    MW1580 (aspS)
    RF122:
    SAB1499c (aspS)
    ST398:
    SAPIG1693 (aspS)
    T0131:
    SAT0131_01728 (sdrC)
    TCH60:
    HMPREF0772_11512 (aspS)
    TW20:
    SATW20_16240 (aspS)
    USA300_TCH1516:
    USA300HOU_1628 (aspS)
    VC40:
    SAVC_07395 (aspS)

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MSKRTTYCGLVTEAFLGQEITLKGWVNNRRDLGGLIFVDLRDREGIVQVVFNPAFSEEAL
    N315            MSKRTTYCGLVTEAFLGQEITLKGWVNNRRDLGGLIFVDLRDREGIVQVVFNPAFSEEAL
    NCTC8325        MSKRTTYCGLVTEAFLGQEITLKGWVNNRRDLGGLIFVDLRDREGIVQVVFNPAFSEEAL
    Newman          MSKRTTYCGLVTEAFLGQEITLKGWVNNRRDLGGLIFVDLRDREGIVQVVFNPAFSEEAL
    USA300_FPR3757  MSKRTTYCGLVTEAFLGQEITLKGWVNNRRDLGGLIFVDLRDREGIVQVVFNPAFSEEAL
                    ************************************************************

    COL             KIAETVRSEYVVEVQGTVTKRDPETVNPKIKTGQVEVQVTNIKVINKSETPPFSINEENV
    N315            KIAETVRSEYVVEVQGTVTKRDPETVNPKIKTGQVEVQVTNIKVINKSETPPFSINEENV
    NCTC8325        KIAETVRSEYVVEVQGTVTKRDPETVNPKIKTGQVEVQVTNIKVINKSETPPFSINEENV
    Newman          KIAETVRSEYVVEVQGTVTKRDPETVNPKIKTGQVEVQVTNIKVINKSETPPFSINEENV
    USA300_FPR3757  KIAETVRSEYVVEVQGTVTKRDPETVNPKIKTGQVEVQVTNIKVINKSETPPFSINEENV
                    ************************************************************

    COL             NVDENIRLKYRYLDLRRQELAQTFKMRHQITRSIRQYLDDEGFFDIETPVLTKSTPEGAR
    N315            NVDENIRLKYRYLDLRRQELAQTFKMRHQITRSIRQYLDDEGFFDIETPVLTKSTPEGAR
    NCTC8325        NVDENIRLKYRYLDLRRQELAQTFKMRHQITRSIRQYLDDEGFFDIETPVLTKSTPEGAR
    Newman          NVDENIRLKYRYLDLRRQELAQTFKMRHQITRSIRQYLDDEGFFDIETPVLTKSTPEGAR
    USA300_FPR3757  NVDENIRLKYRYLDLRRQELAQTFKMRHQITRSIRQYLDDEGFFDIETPVLTKSTPEGAR
                    ************************************************************

    COL             DYLVPSRVHDGEFYALPQSPQLFKQLLMISGFDKYYQIVKCFRDEDLRADRQPEFTQVDI
    N315            DYLVPSRVHDGEFYALPQSPQLFKQLLMISGFDKYYQIVKCFRDEDLRADRQPEFTQVDI
    NCTC8325        DYLVPSRVHDGEFYALPQSPQLFKQLLMISGFDKYYQIVKCFRDEDLRADRQPEFTQVDI
    Newman          DYLVPSRVHDGEFYALPQSPQLFKQLLMISGFDKYYQIVKCFRDEDLRADRQPEFTQVDI
    USA300_FPR3757  DYLVPSRVHDGEFYALPQSPQLFKQLLMISGFDKYYQIVKCFRDEDLRADRQPEFTQVDI
                    ************************************************************

    COL             EMSFVDQEDVMQMGEEMLKKVVKEVKGVEINGAFPRMTYKEAMRRYGSDKPDTRFEMELI
    N315            EMSFVDQEDVMQMGEEMLKKVVKEVKGVEINGAFPRMTYKEAMRRYGSDKPDTRFEMELI
    NCTC8325        EMSFVDQEDVMQMGEEMLKKVVKEVKGVEINGAFPRMTYKEAMRRYGSDKPDTRFEMELI
    Newman          EMSFVDQEDVMQMGEEMLKKVVKEVKGVEINGAFPRMTYKEAMRRYGSDKPDTRFEMELI
    USA300_FPR3757  EMSFVDQEDVMQMGEEMLKKVVKEVKGVEINGAFPRMTYKEAMRRYGSDKPDTRFEMELI
                    ************************************************************

    COL             DVSQLGRDMDFKVFKDTVENDGEIKAIVAKGAAEQYTRKDMDALTEFVNIYGAKGLAWVK
    N315            DVSQLGRDMDFKVFKDTVENDGEIKAIVAKGAAEQYTRKDMDALTEFVNIYGAKGLAWVK
    NCTC8325        DVSQLGRDMDFKVFKDTVENDGEIKAIVAKGAAEQYTRKDMDALTEFVNIYGAKGLAWVK
    Newman          DVSQLGRDMDFKVFKDTVENDGEIKAIVAKGAAEQYTRKDMDALTEFVNIYGAKGLAWVK
    USA300_FPR3757  DVSQLGRDMDFKVFKDTVENDGEIKAIVAKGAAEQYTRKDMDALTEFVNIYGAKGLAWVK
                    ************************************************************

    COL             VVEDGLTGPIGRFFETENVETLLTLTGAEAGDLVMFVADKPNVVAQSLGALRVKLAKELG
    N315            VVEDGLTGPIGRFFETENVETLLTLTGAEAGDLVMFVADKPNVVAQSLGALRVKLAKELG
    NCTC8325        VVEDGLTGPIGRFFETENVETLLTLTGAEAGDLVMFVADKPNVVAQSLGALRVKLAKELG
    Newman          VVEDGLTGPIGRFFETENVETLLTLTGAEAGDLVMFVADKPNVVAQSLGALRVKLAKELG
    USA300_FPR3757  VVEDGLTGPIGRFFETENVETLLTLTGAEAGDLVMFVADKPNVVAQSLGALRVKLAKELG
                    ************************************************************

    COL             LIDETKLNFLWVTDWPLLEYDEDAKRYVAAHHPFTSPKEADIAKLGTAPEEAEANAYDIV
    N315            LIDETKLNFLWVTDWPLLEYDEDAKRYVAAHHPFTSPKEADIAKLGTAPEEAEANAYDIV
    NCTC8325        LIDETKLNFLWVTDWPLLEYDEDAKRYVAAHHPFTSPKEADIAKLGTAPEEAEANAYDIV
    Newman          LIDETKLNFLWVTDWPLLEYDEDAKRYVAAHHPFTSPKEADIAKLGTAPEEAEANAYDIV
    USA300_FPR3757  LIDETKLNFLWVTDWPLLEYDEDAKRYVAAHHPFTSPKEADIAKLGTAPEEAEANAYDIV
                    ************************************************************

    COL             LNGYELGGGSIRIHDGELQEKMFEVLGFTKEQAQEQFGFLLDAFKYGAPPHGGIALGLDR
    N315            LNGYELGGGSIRIHDGELQEKMFEVLGFTKEQAQEQFGFLLDAFKYGAPPHGGIALGLDR
    NCTC8325        LNGYELGGGSIRIHDGELQEKMFEVLGFTKEQAQEQFGFLLDAFKYGAPPHGGIALGLDR
    Newman          LNGYELGGGSIRIHDGELQEKMFEVLGFTKEQAQEQFGFLLDAFKYGAPPHGGIALGLDR
    USA300_FPR3757  LNGYELGGGSIRIHDGELQEKMFEVLGFTKEQAQEQFGFLLDAFKYGAPPHGGIALGLDR
                    ************************************************************

    COL             LVMLLTNRTNLRDTIAFPKTASATCLLTNAPGEVSDKQLEELSLRIRH
    N315            LVMLLTNRTNLRDTIAFPKTASATCLLTNAPGEVSDKQLEELSLRIRH
    NCTC8325        LVMLLTNRTNLRDTIAFPKTASATCLLTNAPSEVSDKQLEELSLRIRH
    Newman          LVMLLTNRTNLRDTIAFPKTASATCLLTNAPGEVSDKQLEELSLRIRH
    USA300_FPR3757  LVMLLTNRTNLRDTIAFPKTASATCLLTNAPGEVSDKQLEELSLRIRH
                    *******************************.****************

  1. Stefani R Mladenova, Kathryn R Stein, Lianne Bartlett, Kelly Sheppard
    Relaxed tRNA specificity of the Staphylococcus aureus aspartyl-tRNA synthetase enables RNA-dependent asparagine biosynthesis.
    FEBS Lett: 2014, 588(9);1808-12
    [PubMed:24685427] [WorldCat.org] [DOI] (I p)