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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005554000
- symbol?: lmrS
- synonym:
- description?: MFS transporter
- MFS transporter
- EmrB/QacA family drug resistance transporter
- drug resistance transporter EmrB/QacA subfamily protein
- EmrB-QacA subfamily drug resistance transporter, putative
- multidrug efflux MFS transporter LmrS
- drug resistance MFS transporter, drug:H+ antiporter-1 (14 Spanner) (DHA2) family protein
- Drug resistance transporter, EmrB/QacA subfamily
- EmrB/QacA subfamily drug resistance transporter
- H+ antiporter-2 family protein
- lincomycin resistance protein LmrB
- major facilitator transporter
- multidrug resistance protein
- multidrug resistance protein B
- multidrug resistance transporter
- pseudogene
- putative transport protein
- transport protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5697024..5698419
- synteny block?: BlockID0043150
- occurrence?: in 100% of 33 strains
lmrS: lincomycin multidrug resistance transporter from staphylococci [1]
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2105
08BA02176:
C248_2203
11819-97:
MS7_2190
6850:
RSAU_002011
71193:
ST398NM01_2227
ECT-R 2:
ECTR2_2028
ED133:
SAOV_2214c
ED98:
SAAV_2228
HO 5096 0412:
SAEMRSA15_20720
JH1:
SaurJH1_2236
JH9:
SaurJH9_2198
JKD6008:
SAA6008_02205
JKD6159:
SAA6159_02078
LGA251:
SARLGA251_19620
M013:
M013TW_2133
MRSA252:
SAR2257
MSHR1132:
SAMSHR1132_19990
MSSA476:
SAS2068
Mu3:
SAHV_2150
Mu50:
SAV2166
MW2:
MW2093
RF122:
SAB2048c
ST398:
SAPIG2227
T0131:
SAT0131_02335
TCH60:
HMPREF0772_11025 (lmrB3)
TW20:
SATW20_23020
USA300_TCH1516:
USA300HOU_2158
VC40:
SAVC_09705
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAKVELTTRRRNFIVAVMLISAFVAILNQTLLNTALPSIMRELNINESTSQWLVTGFMLV
N315 MAKVELTTRRRNFIVAVMLISAFVAILNQTLLNTALPSIMRELNINESTSQWLVTGFMLV
NCTC8325 MAKVELTTRRRNFIVAVMLISAFVAILNQTLLNTALPSIMRELNINESTSQWLVTGFMLV
Newman MAKVELTTRRRNFIVAVMLISAFVAILNQTLLNTALPSIMRELNINESTSQWLVTGFMLV
USA300_FPR3757 MAKVELTTRRRNFIVAVMLISAFVAILNQTLLNTALPSIMRELNINESTSQWLVTGFMLV
************************************************************
COL NGVMIPLTAYLMDRIKTRPLYLAAMGTFLLGSIVAALAPNFGVLMLARVIQAMGAGVLMP
N315 NGVMIPLTAYLMDRIKTRPLYLAAMGTFLLGSIVAALAPNFGVLMLARVIQAMGAGVLMP
NCTC8325 NGVMIPLTAYLMDRIKTRPLYLAAMGTFLLGSIVAALAPNFGVLMLARVIQAMGAGVLMP
Newman NGVMIPLTAYLMDRIKTRPLYLAAMGTFLLGSIVAALAPNFGVLMLARVIQAMGAGVLMP
USA300_FPR3757 NGVMIPLTAYLMDRIKTRPLYLAAMGTFLLGSIVAALAPNFGVLMLARVIQAMGAGVLMP
************************************************************
COL LMQFTLFTLFSKEHRGFAMGLAGLVIQFAPAIGPTVTGLIIDQASWRVPFIIIVGIAILA
N315 LMQFTLFTLFSKEHRGFAMGLAGLVIQFAPAIGPTVTGLIIDQASWRVPFIIIVGIALVA
NCTC8325 LMQFTLFTLFSKEHRGFAMGLAGLVIQFAPAIGPTVTGLIIDQASWRVPFIIIVGIAILA
Newman LMQFTLFTLFSKEHRGFAMGLAGLVIQFAPAIGPTVTGLIIDQASWRVPFIIIVGIAILA
USA300_FPR3757 LMQFTLFTLFSKEHRGFAMGLAGLVIQFAPAIGPTATGLIIDQASWRVPFIIILGIAILA
***********************************.*****************:***::*
COL FVFGLVSISSYNEVKYTKLDKRSVMYSTIGFGLMLYAFSSAGDLGFTSPIVIGALILSMV
N315 FVFGLVSISSYNEVKYTKLDKRSVMYSTIGFGLMLYAFSSAGDLGFTSPIVIGALIISMV
NCTC8325 FVFGLVSISSYNEVKYTKLDKRSVMYSTIGFGLMLYAFSSAGDLGFTSPIVIGALILSMV
Newman FVFGLVSISSYNEVKYTKLDKRSVMYSTIGFGLMLYAFSSAGDLGFTSPIVIGALILSMV
USA300_FPR3757 FVFGLVSISSYNEVKYTKLDKRSVMYSTIGFGLMLYAFSSAGDLGFTSPIVIGALILSMV
********************************************************:***
COL IIYLFIRRQFNITNALLNLRVFKNRTFALCTISSMIIMMSMVGPALLIPLYVQNSLSLSA
N315 IIYLFIRRQFNITNVLLNLRVFKNRTFALCTISSMIIMMSMVGPALLIPLYVQNSLSLSA
NCTC8325 IIYLFIRRQFNITNALLNLRVFKNRTFALCTISSMIIMMSMVGPALLIPLYVQNSLSLSA
Newman IIYLFIRRQFNITNALLNLRVFKNRTFALCTISSMIIMMSMVGPALLIPLYVQNSLSLSA
USA300_FPR3757 IIYLFIRRQFNITNALLNLRVFKNRTFALCTISSMIIMMSMVGPALLIPLYVQNSLSLSA
**************.*********************************************
COL LLSGLVIMPGAIINGIMSVFTGKFYDKYGPRPLIYTGFTILTITTIMLCFLHTDTSYTYL
N315 LLSGLVIMPGAIINGIMSVFTGKFYDKYGPRPLIYTGFTILTITTIMLCFLHTDTSYTYL
NCTC8325 LLSGLVIMPGAIINGIMSVFTGKFYDKYGPRPLIYTGFTILTITTIMLCFLHTDTSYTYL
Newman LLSGLVIMPGAIINGIMSVFTGKFYDKYGPRPLIYTGFTILTITTIMLCFLHTDTSYTYL
USA300_FPR3757 LLSGLVIMPGAIINGIMSVFTGKFYDKYGPRPLIYTGFTILTITTIMLCFLHTDTSYTYL
************************************************************
COL IVVYAIRMFSVSLLMMPINTTGINSLRNEEISHGTAIMNFGRVMAGSLGTALMVTLMSFG
N315 IVVYAIRMFSVSLLMMPINTTGINSLRNEEISHGTAIMNFGRVMAGSLGTALMVTLMSFG
NCTC8325 IVVYAIRMFSVSLLMMPINTTGINSLRNEEISHGTAIMNFGRVMAGSLGTALMVTLMSFG
Newman IVVYAIRMFSVSLLMMPINTTGINSLRNEEISHGTAIMNFGRVMAGSLGTALMVTLMSFG
USA300_FPR3757 IVVYAIRMFSVSLLMMPINTTGINSLRNEEISHGTAIMNFGRVMAGSLGTALMVTLMSFG
************************************************************
COL AKIFLSTSPSHLTATEIKQQSIAIGVDISFAFVAVLVMAAYVIALFIREPKEIESNRRKF
N315 AKIFLSTSPSHLTATEIKQQSIAIGVDISFAFVAVLVMAAYVIALFIREPKEIESNRRKF
NCTC8325 AKIFLSTSPSHLTATEIKQQSIAIGVDISFAFVAVLVMAAYVIALFIREPKEIESNRRKF
Newman AKIFLSTSPSHLTATEIKQQSIAIGVDISFAFVAVLVMAAYVIALFIREPKEIESNRRKF
USA300_FPR3757 AKIFLSTSPSHLTATEIKQQSIAIGVDISFAFVAVLVMAAYVIALFIREPKEIESNRRKF
************************************************************
- ↑ Jody L Floyd, Kenneth P Smith, Sanath H Kumar, Jared T Floyd, Manuel F Varela
LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus.
Antimicrob Agents Chemother: 2010, 54(12);5406-12
[PubMed:20855745] [WorldCat.org] [DOI] (I p)