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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005756000
- symbol?: ureE
- synonym:
- description?: urease accessory protein UreE
- urease accessory protein UreE
- urease accessory protein, putative
- ureE urease accessory , N-terminal domain protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5851005..5851457
- synteny block?: BlockID0045020
- occurrence?: in 100% of 34 strains
ureE : urease accessory nickel metallochaperone UreE [1]
Urease (alt: urea amidohydrolase) processes urea into more bioavailable ammonia and bicarbonate. The overall structure consists of a trimer of alpha-beta-gamma subunit heterotrimers. Apo-urease must be "activated" to its functional form by urease accessory proteins including carbamoylation of lysine-221 of the alpha subunit and formation of a diatomic nickel metallocenter.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2229 (ureE)
08BA02176:
C248_2330 (ureE)
11819-97:
MS7_2309
6850:
RSAU_002124 (ureE)
71193:
ST398NM01_2341
ECT-R 2:
ECTR2_2151
ED133:
SAOV_2330
ED98:
SAAV_2353 (ureE)
HO 5096 0412:
SAEMRSA15_21880 (ureE)
JH1:
SaurJH1_2358 (ureE)
JH9:
SaurJH9_2315 (ureE)
JKD6008:
SAA6008_02327 (ureE)
JKD6159:
SAA6159_02195 (ureE)
JSNZ:
JSNZ_002257 (ureE)
LGA251:
SARLGA251_20740 (ureE)
M013:
M013TW_2248
MRSA252:
SAR2375 (ureE)
MSHR1132:
SAMSHR1132_21160
MSSA476:
SAS2181 (ureE)
Mu3:
SAHV_2275 (ureE)
Mu50:
SAV2291 (ureE)
MW2:
MW2209 (ureE)
RF122:
SAB2163 (ureE)
ST398:
SAPIG2341
T0131:
SAT0131_02469 (panB)
TCH60:
HMPREF0772_10907 (ureE)
TW20:
SATW20_24220 (ureE)
USA300_TCH1516:
USA300HOU_2272 (ureE)
VC40:
SAVC_10315 (ureE)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MIVEEIQGNIANLSNSEKQKHVEKVYLENSDLVKRIQRVVTDHGTEIGIRLKQPIDLQYG
N315 MIVEEIQGNIANLSNSEKQKHVEKVYLENSDLVKRIQRVVTDHGTEIGIRLKQPIDLQYG
NCTC8325 MIVEEIQGNIANLSNSEKQKHVEKVYLENSDLVKRIQRVVTDHGTEIGIRLKQPIDLQYG
Newman MIVEEIQGNIANLSNSEKQKHVEKVYLENSDLVKRIQRVVTDHGTEIGIRLKQPIDLQYG
USA300_FPR3757 MIVEEIQGNIANLSNSEKQKHVEKVYLENSDLVKRIQRVVTDHGTEIGIRLKQPIDLQYG
************************************************************
COL DILYADDHNMIIVDVNSEDLLVIQPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLV
N315 DILYADDHNMIIVDVNSEDLLVIQPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLV
NCTC8325 DILYADDHNMIIVDVNSEDLLVIQPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLV
Newman DILYADDHNMIIVDVNSEDLLVIQPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLV
USA300_FPR3757 DILYADDHNMIIVDVNSEDLLVIQPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLV
************************************************************
COL EDLLKSLGIPYVREDRKVNKAFRHIGHSHD
N315 EDLLKSLGIPYVREDRKVNKAFRHIGHSHD
NCTC8325 EDLLKSLGIPYVREDRKVNKAFRHIGHSHD
Newman EDLLKSLGIPYVREDRKVNKAFRHIGHSHD
USA300_FPR3757 EDLLKSLGIPYVREDRKVNKAFRHIGHSHD
******************************
- ↑ Chunyi Zhou, Fatema Bhinderwala, McKenzie K Lehman, Vinai C Thomas, Sujata S Chaudhari, Kelsey J Yamada, Kirk W Foster, Robert Powers, Tammy Kielian, Paul D Fey
Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection.
PLoS Pathog: 2019, 15(1);e1007538
[PubMed:30608981] [WorldCat.org] [DOI] (I e)Humaira Siddiqui, Atia-Tul-Wahab, Aftab Ahmed, M Iqbal Choudhary
Structural and Functional Analysis of Urease Accessory Protein E from Vancomycin-Resistance Staphylococcus aureus MU50 Strain.
Protein Pept Lett: 2023, 30(9);754-762
[PubMed:37533244] [WorldCat.org] [DOI] (I p)