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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005759000
- symbol?: ureD
- synonym:
- description?: urease accessory protein UreD
- urease accessory protein UreD
- urease accessory protein
- urease accessory protein UreD, putative
- ureD urease accessory family protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5852766..5853602
- synteny block?: BlockID0045050
- occurrence?: in 100% of 34 strains
ureD : urease accessory scaffold protein UreD [1]
Urease (alt: urea amidohydrolase) processes urea into more bioavailable ammonia and bicarbonate. The overall structure consists of a trimer of alpha-beta-gamma subunit heterotrimers. Apo-urease must be "activated" to its functional form by urease accessory proteins including carbamoylation of lysine-221 of the alpha subunit and formation of a diatomic nickel metallocenter.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2232 (ureD)
08BA02176:
C248_2333 (ureD)
11819-97:
MS7_2312
6850:
RSAU_002127 (ureD)
71193:
ST398NM01_2344
ECT-R 2:
ECTR2_2154
ED133:
SAOV_2333
ED98:
SAAV_2356 (ureD)
HO 5096 0412:
SAEMRSA15_21910 (ureD)
JH1:
SaurJH1_2361
JH9:
SaurJH9_2318
JKD6008:
SAA6008_02330
JKD6159:
SAA6159_02198 (ureD)
JSNZ:
JSNZ_002260
LGA251:
SARLGA251_20770 (ureD)
M013:
M013TW_2251
MRSA252:
SAR2378 (ureD)
MSHR1132:
SAMSHR1132_21190
MSSA476:
SAS2184
Mu3:
SAHV_2278 (ureD)
Mu50:
SAV2294 (ureD)
MW2:
MW2212 (ureD)
RF122:
SAB2166 (ureD)
ST398:
SAPIG2344 (ureD)
T0131:
SAT0131_02472 (ldh)
TCH60:
HMPREF0772_10904 (ureD)
TW20:
SATW20_24250 (ureD)
USA300_TCH1516:
USA300HOU_2275 (ureD)
VC40:
SAVC_10330
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MDEQQWTGQLDLTVFFDGNRSVSRDIFFEKALKVIRPVYLNQSTIPTFYIVNVGGGYLDG
N315 ------------------------------------------------------------
NCTC8325 MDEQQWTGQLDLTVFFDGNRSVSRDIFFEKALKVIRPVYLNQSTIPTFYIVNVGGGYLDG
Newman MDEQQWTGQLDLTVFFDGNRSVSRDIFFEKALKVIRPVYLNQSTIPTFYIVNVGGGYLDG
USA300_FPR3757 MDEQQWTGQLDLTVFFDGNRSVSRDIFFEKALKVIRPVYLNQSTIPTFYIVNVGGGYLDG
COL DRYRMNVNVEDNAKVTLTSQGATKIYKTPSNHVEQYQTFNLKDNAYLEYVADPIIAYENA
N315 ----MNVNVEDNAKVTLTSQGATKIYKTPSNHVEQYQTFNLKDNAYLEYVADPIIAYENA
NCTC8325 DRYRMNVNVEDNAKVTLTSQGATKIYKTPSNHVEQYQTFNLKDNAYLEYVADPIIAYENA
Newman DRYRMNVNVEDNAKVTLTSQGATKIYKTPSNHVEQYQTFNLKDNAYLEYVADPIIAYENA
USA300_FPR3757 DRYRMNVNVEDNAKVTLTSQGATKIYKTPSNHVEQYQTFNLKDNAYLEYVADPIIAYENA
********************************************************
COL KFYQHNTFNLNNSSSLFYTDILTPGYSKTGEAFKYQYMHLINEIYIEDELVTYDNLLLNP
N315 KFYQHNTFNLNNSSSLFYTDILTPGYSKTGEAFKYQYMHLINEIYIEDELVTYDNLLLNP
NCTC8325 KFYQHNTFNLNNSSSLFYTDILTPGYSKTGEAFKYQYMHLINEIYIEDELVTYDNLLLNP
Newman KFYQHNTFNLNNSSSLFYTDILTPGYSKTGEAFKYQYMHLINEIYIEDELVTYDNLLLNP
USA300_FPR3757 KFYQHNTFNLNNSSSLFYTDILTPGYSKTGEAFKYQYMHLINEIYIEDELVTYDNLLLNP
************************************************************
COL NKQSINEIGYMEHYSHYGSAYFIHEDVNQKLIDSVYETISSYSNTFDCRVAISQLPTHGF
N315 NKQSINEIGYMEHYSHYGSAYFIHEDVNQKLIDSVYETISSYSNTFDCRVAISQLPTHGF
NCTC8325 NKQSINEIGYMEHYSHYGSAYFIHEDVNQKLIDSVYETISSYSNTFDCRVAISQLPTHGF
Newman NKQSINEIGYMEHYSHYGSAYFIHEDVNQKLIDSVYETISSYSNTFDCRVAISQLPTHGF
USA300_FPR3757 NKQSINEIGYMEHYSHYGSAYFIHEDVNQKLIDSVYETISSYSNTFDCRVAISQLPTHGF
************************************************************
COL AVRIFAYRTQIIEKILGTIQSYIAENIYDRKLDFLRKY
N315 AVRIFAYRTQIIEKILGTIQSYIAENIYDRKLDFLRKY
NCTC8325 AVRIFAYRTQIIEKILGTIQSYIAENIYDRKLDFLRKY
Newman AVRIFAYRTQIIEKILGTIQSYIAENIYDRKLDFLRKY
USA300_FPR3757 AVRIFAYRTQIIEKILGTIQSYIAENIYDRKLDFLRKY
**************************************
- ↑ Chunyi Zhou, Fatema Bhinderwala, McKenzie K Lehman, Vinai C Thomas, Sujata S Chaudhari, Kelsey J Yamada, Kirk W Foster, Robert Powers, Tammy Kielian, Paul D Fey
Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection.
PLoS Pathog: 2019, 15(1);e1007538
[PubMed:30608981] [WorldCat.org] [DOI] (I e)