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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005872000
- symbol?: —
- synonym:
- description?: LytTR family transcriptional regulator
- LytTR family transcriptional regulator
- LytTR family DNA-binding domain-containing protein
- response regulator transcription factor
- transcriptional regulator, putative
- HTH-type transcriptional regulator
- LytTr DNA-binding domain family
- lytTr DNA-binding domain protein
- LytTr DNA-binding region-containing protein
- transcriptional regulator
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5944603..5945046
- synteny block?: BlockID0046170
- occurrence?: in 100% of 34 strains
brpR : biofilm-regulating protein repressor [1] [2]
The BrpSR system represents a structurally distinct LytTR-type two-component system that likely responds to a competence-stimulating pheromone. Upon pheromone binding, BrpR is released and biofilm production is repressed. BrpR also may be involved in more global regulation including sortase repression, metabolic dormancy, late-stage competence and LrgA-mediated programmed cell death.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2302
08BA02176:
C248_2408
11819-97:
MS7_2381
6850:
RSAU_002198
71193:
ST398NM01_2416
ECT-R 2:
ECTR2_2223
ED133:
SAOV_2407
ED98:
SAAV_2428
HO 5096 0412:
SAEMRSA15_22610
JH1:
SaurJH1_2433
JH9:
SaurJH9_2387
JKD6008:
SAA6008_02401 (lytT)
JKD6159:
SAA6159_02267 (lytT)
LGA251:
SARLGA251_21460
M013:
M013TW_2321
MRSA252:
SAR2449
MSHR1132:
SAMSHR1132_21880
MSSA476:
SAS2254
Mu3:
SAHV_2347
Mu50:
SAV2363
MW2:
MW2284
RF122:
SAB2242
ST398:
SAPIG2416
T0131:
SAT0131_02551 (tnpB-3)
TCH60:
HMPREF0772_10829
TW20:
SATW20_24950
USA300_TCH1516:
USA300HOU_2346
VC40:
SAVC_10685
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 | |
| JSNZ |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
COL MMKLNLFINANETESYIDIHAPKMNDNVQSIINAVNDLDKSHTLVGYIDKEIHIINVSDV
N315 MMKLNLFINANETESYIDIHAPKMNDHVQSIINAVNDLDKSHTLVGYIDKEIHIINVSDV
NCTC8325 MMKLNLFINANETESYIDIHAPKMNDNVQSIINAVNDLDKSHTLVGYIDKEIHIINVSDV
Newman MMKLNLFINANETESYIDIHAPKMNDNVQSIINAVNDLDKSHTLVGYIDKEIHIINVSDV
USA300_FPR3757 MMKLNLFINANETESYIDIHAPKMNDNVQSIINAVNDLDKSHTLVGYIDKEIHIINVSDV
JSNZ MMKLNLFINANETESYIDIHAPKMNDHVQSIINAVNDLDKSHTLVGYIDKEIHIIHISDV
**************************:****************************::***
COL ITFQVINKNVTAITSNQKFKLKLRLYELEKQLPQHFIRISKSEIVNKYYIEKLLLEPNGL
N315 ITFQVINKNVTAITSNQKFKLKLRLYELEKQLPQHFIRISKSEIVNKYYIEKLLLEPNGL
NCTC8325 ITFQVINKNVTAITSNQKFKLKLRLYELEKQLPQHFIRISKSEIVNKYYIEKLLLEPNGL
Newman ITFQVINKNVTAITSNQKFKLKLRLYELEKQLPQHFIRISKSEIVNKYYIEKLLLEPNGL
USA300_FPR3757 ITFQVINKNVTAITSNQKFKLKLRLYELEKQLPQHFIRISKSEIVNKYYIEKLLLEPNGL
JSNZ ITFQVINKNVTAITSNQKFKLKLRLYELEKQLPQHFIRISKSEIVNKYYIEKLLLEPNGL
************************************************************
COL IRMYLKDAHYTYSSRRYLKSIKERLSI
N315 IRMYLKDAHYTYSSRRYLKSIKERLSI
NCTC8325 IRMYLKDAHYTYSSRRYLKSIKERLSI
Newman IRMYLKDAHYTYSSRRYLKSIKERLSI
USA300_FPR3757 IRMYLKDAHYTYSSRRYLKSIKERLSI
JSNZ IRMYLKDAHYTYSSRRYLKSIKERLSI
***************************
- ↑ Zank A, Schulte L, Brandon X, Carstensen L, Wescott A, Schwan WR. Mutations of the brpR and brpS genes affect biofilm formation in Staphylococcus aureus. World J Clin Infect Dis 2022; 12(1): 20-32 [DOI: 10.5495/wjcid.v12.i1.20]
- ↑ Zhengzhong Zou, Hua Qin, Amanda E Brenner, Rahul Raghavan, Jess A Millar, Qiang Gu, Zhoujie Xie, Jens Kreth, Justin Merritt
LytTR Regulatory Systems: A potential new class of prokaryotic sensory system.
PLoS Genet: 2018, 14(10);e1007709
[PubMed:30296267] [WorldCat.org] [DOI] (I e)Shinya Yamauchi, So Shimoda, Akio Kawahara, Tomohiro Sugahara, Shuhei Yamamoto, Masao Kitabayashi, Atsushi Sogabe, Christine A Jansen, Ryuta Tobe, Ryota Hirakawa, Jahidul Islam, Mutsumi Furukawa, Hiroshi Yoneyama, Tomonori Nochi
Identification of four genes responsible for antimicrobial resistance of MEL-B against S. aureus.
Biochem Biophys Res Commun: 2024, 699;149566
[PubMed:38290176] [WorldCat.org] [DOI] (I p)