Jump to navigation
Jump to search
⊟Summary[edit | edit source]
- pan ID?: SAUPAN006013000
- symbol?: —
- synonym:
- description?: Txe/YoeB family addiction module toxin
- Txe/YoeB family addiction module toxin
- addiction module antitoxin
- addiction module, toxin
- Addiction module toxin, Txe/YoeB family
- toxin-antitoxin system, toxin component, Txe/YoeB family
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6073164..6073510
- synteny block?: BlockID0047570
- occurrence?: in 73% of 33 strains
yoeB2 (txe2): type II addiction module ribosome-dependent RNase 2 toxin [1]
There is a crystal structure: 7V6W
Under normal conditions, YefM2 sequesters YoeB2 rendering it inert. Under stress conditions, TrfA-augmented ClpCP proteolyzes YefM2, YoeB2 binds to active ribosomes and cleaves messenger RNA transcripts near the start codon resulting in de novo translation shutdown.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2393
08BA02176:
—
11819-97:
MS7_2470
6850:
—
71193:
—
ECT-R 2:
ECTR2_2314
ED133:
SAOV_2507c
ED98:
SAAV_2523
HO 5096 0412:
—
JH1:
SaurJH1_2532
JH9:
SaurJH9_2483
JKD6008:
SAA6008_02498
JKD6159:
SAA6159_02354
LGA251:
SARLGA251_22370
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
SAS2348
Mu3:
SAHV_2440
Mu50:
SAV2456
MW2:
MW2380
RF122:
SAB2339c
ST398:
—
T0131:
SAT0131_02656 (rbgA)
TCH60:
HMPREF0772_10732
TW20:
SATW20_25850
USA300_TCH1516:
USA300HOU_2446
VC40:
SAVC_11155
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRR
N315 MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRR
NCTC8325 MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRR
USA300_FPR3757 MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRR
****************:*******************************************
COL INHQHRVVYTVDDRNKEVLILSAWSHYD
N315 INHQHRVVYTVDDRNKEVLILSAWSHYD
NCTC8325 INHQHRVVYTVDDRNKEVLILSAWSHYD
USA300_FPR3757 INHQHRVVYTVDDRNKEVLILSAWSHYD
****************************
- ↑ Xinyu Qi, Kimberly M Brothers, Dongzhu Ma, Jonathan B Mandell, Niles P Donegan, Ambrose L Cheung, Anthony R Richardson, Kenneth L Urish
The Staphylococcus aureus toxin-antitoxin system YefM-YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation.
J Bone Jt Infect: 2021, 6(7);241-253
[PubMed:34262845] [WorldCat.org] [DOI] (P e)Christopher F Schuster, Ralph Bertram
Toxin-Antitoxin Systems of Staphylococcus aureus.
Toxins (Basel): 2016, 8(5);
[PubMed:27164142] [WorldCat.org] [DOI] (I e)Niles P Donegan, Earl T Thompson, Zhibiao Fu, Ambrose L Cheung
Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus.
J Bacteriol: 2010, 192(5);1416-22
[PubMed:20038589] [WorldCat.org] [DOI] (I p)